Association between triglyceride glucose index and abnormal liver function in both urban and rural Chinese adult populations

Abstract

The purpose of this study was to investigate the association between triglyceride glucose (TyG) index and abnormal liver function both in urban and rural Chinese adult populations. The 5824 urban (Nanjing) and 20,269 rural (Hefei) Chinese adults, from random selected households provided clinical history, glucose, lipids, anthropometric, and blood pressure measurements. Liver functions were assessed using Alanine Aminotransferase (ALT). Linear regression was applied to examine the dose-response relationship between TyG index and ALT. Logistic regression was used to estimate the association between TyG index and abnormal liver and function. Cubic spline models were applied to investigate the dose-response association between TyG index and abnormal liver function. C-statistics was used to compare the discriminable capacity over triglyceride, glucose and TyG index. Linear doseresponse relationship was identified between TyG index and ALT as 1.222 IU increase by 1 unit increase of TyG index (1.242 for urban population and 1.210 for rural population). The 6.0% of urban and 11.0% of rural Chinese adults were observed to have abnormal liver function. The linear association between TyG index and abnormal liver function was revealed as 2.044 (1.930 to 2.165) of odds ratio by in unit increase of TyG index (2.334 for urban population and 1.990 for rural population). Higher C-statistics was found for TyG index compared with fasting glucose and triglyceride both in Chinese urban and rural populations. This study suggested in both urban and rural Chinese adult populations, TyG index is associated with abnormal liver function. TyG index is a potential indicator to identify high-risk individuals with metabolic disorders, for example impaired liver function in Chinese population, especially in Chinese urban population.Abbreviations: ALT = alanine aminotransferase, CAC = coronary artery calcification, IR = insulin resistance, OR = odds ratio, TyG index = triglyceride glucose index.

Dose-response association between physical activity and clustering of modifiable cardiovascular risk factors among 26,093 Chinese adults

“…Two independent surveys were implemented in two Chinese places: Nanjing and Hefei [6]. The Nanjing Community Cardiovascular Risk Survey was processed by random cluster sampling [7], between 2011 and 2013, among adults resident in 6 communities of Nanjing, the capital city of Jiangsu Province in China.…”

“…Five thousand eight hundred twenty-four participants completed their clinical examination and survey (response rate: 90%). The Hefei Community Cardiovascular Risk Survey was also implemented by a random cluster sampling [6], between 2012 and 2013 among the adults residents in 10 rural areas of Hefei, the capital city of Anhui Province in China. In every rural area of Hefei, one township was randomly chosen.…”

Association of Two Indices of Insulin Resistance Marker with Abnormal Liver Function Tests: A Cross-Sectional Population Study in Taiwanese Adults

“…Furthermore, in a survey of 6445 Chinese adults, which covered urban and rural areas between 2011 and 2013, a significant association was found between more severe insulin resistance, as indicated by higher TyG index, and a higher risk of impaired liver function in a fully adjusted model (OR = 2.04, 95% CI: 1.93-2.17, p < 0.0001) [15]. In our study, a higher ALT was observed in a group with higher TyG levels, which is consistent with a prior study that found an increase in ALT by 1.22 (95% CI: 1.21-1.24) IU for a one-unit increment of TyG [15].…”

“…Since the clamp technique is costly and tedious, it is no longer durable for daily clinical practice [13]. Likewise, the homeostasis model assessment of insulin resistance (HOMA-IR) method, which calculates IR by integrating fasting glucose and insulin levels, is less invasive and tedious [14,15]. Although, the HOMA-IR indices are more widely used and beneficial in epidemiological and clinical studies for forecasting diabetes incidence in different groups.…”

The value of the triglyceride-glucose index in the diagnosis of insulin resistance in early forms of non-alcoholic fatty liver disease

“…Этот метод является экономически значительно более выгодным, чем HOMA-IR, так как анализ на триглицериды в среднем в 6 раз дешевле анализа на инсулин. Последующие многочисленные исследования ученых подтвердили диагностическую роль ТГИ для оценки нарушенного эндогенного гликемического у здоровых лиц, у взрослых, детей и женщин с избыточным весом, ожирением, метаболическим синдромом [4,5], для прогноза развития НАЖБП [6,7] и сахарного диабета 2 типа [8,9], инсулинорезистентности [10]. Он коррелировал с эугликемическим гиперинсулинемическим клэмп-тестом и HOMA-IR [10,11] и даже продемонстрировал лучшую чувствительность в выявлении ИР, чем HOMA-IR [12].…”