Dose-response association between physical activity and clustering of modifiable cardiovascular risk factors among 26,093 Chinese adults

Abstract

Background: There is uncertain evidence in the dose-response association between overall physical activity levels and clustering of cardiovascular diseases modifiable risk factors (CVDMRF) in Chinese adults. This study examined the hypothesis whether inverse dose-response association between overall physical activity levels and clustering of CVDMRF in Chinese adults exist. Methods: Twenty-six thousand ninety-three Chinese adult participants were recruited by two independent surveys in Nanjing and Hefei during 2011 to 2013, from random selected households provided smoking, glucose, lipids, anthropometric, and blood pressure measurements. Logistic regression model was applied to examine the doseresponse association between overall physical activity (measured by metabolic equivalent task (MET)-minutes per week) and having ≥1, ≥2, and ≥ 3 CVDMRF (dyslipidemia, hypertension, diabetes, cigarette smoking, and overweight). Results: An inverse linear dose-response relationship between physical activity and clustering of CVDMRF was identified, as increased physical activity levels are associated with lower odds of having clustering of CVDMRF. The adjusted odds ratio (95% confidence interval) of having ≥1, ≥2, and ≥ 3 CVRF for moderate physical activity group and high physical activity group was 0.88 (0.79 to 0.98) and 0.88 (0.79 to 0.99), 0.85 (0.78 to 0.92) and 0.85 (0.78 to 0.92), 0.84 (0.76 to 0.91) and 0.81 (0.74 to 0.89), respectively, with low physical activity as reference group. Conclusions: Among Chinese adults, physical activity level inversely associates with clustering of CVDMRF, especially in those aged 35-54 years. Health promotion including improve physical activity should be advocated. The potential role of physical activity in the clustering of CVDMRF warrants further validation.

Self-Reported Modifiable Risk Factors of Cardiovascular Disease among Older Adults in Malaysia: A Cross-Sectional Study of Prevalence and Clustering

“…In this study, older adults who were physically inactive were more likely to present ≥2 or ≥3 modifiable CVD risk factors, which was consistent with other reports [29,39]. Shi et al identified an inverse dose-response association between physical activity and clustering of CVD modifiable risk factors among Chinese adults, suggesting about 15% decreased prevalence of having ≥2 CVD risk factors might be avoided if the inactive individuals (<600 MET-min/week) improved their physical activity to moderate level (600-3000 MET-min/week) [39]. Although the intensity, mode, duration, and frequency of physical activity can strongly affect the outcome, older adults who often have multiple health conditions are encouraged to be as physically active as possible to gain more health benefits from physical activity.…”

“…Unhealthy lifestyle behaviors, such as high alcohol consumption, low fruit and vegetable intake, physical inactivity, and sedentary behavior, are known to increase CVD risk [38]. In this study, older adults who were physically inactive were more likely to present ≥2 or ≥3 modifiable CVD risk factors, which was consistent with other reports [29,39]. Shi et al identified an inverse dose-response association between physical activity and clustering of CVD modifiable risk factors among Chinese adults, suggesting about 15% decreased prevalence of having ≥2 CVD risk factors might be avoided if the inactive individuals (<600 MET-min/week) improved their physical activity to moderate level (600-3000 MET-min/week) [39].…”

Association between physical activity energy expenditure and cardiometabolic risk factor clustering among Chinese adults in 2015

“…Regarding cardiovascular diseases’ modifiable risk factors (CVDMRF) and total PA, a cross-sectional study from two cities in China identified that meeting the PA recommendations was related to a 15% decrease in the OR for having ≥2 factors (dyslipidemia, hypertension, diabetes, cigarette smoking, and overweight) compared to inactivity. 17 On analyzing PAEE from transportation and leisure-time domains, our study detected a similarly inverse linear dose-response association between a higher PA level and a lower percentage of CMRF clustering among Chinese patients aged 18–64 years in 2015. Those with inactivity had a 9% reduction in having 2 CMRFs if they met PA recommendations, and this benefit was doubled in those having 4 CMRFs.…”

“…4 Regarding CVDMRFs, several large cross-sectional studies presented the highly striking and seemingly increasing prevalence of its clustering in Chinese adults over the last 20 years. 3 , 17 As such, focusing on CMRF clustering may be helpful in individual-level cardiovascular health management practice.…”

“…10 , 11 , 12 Previous studies have identified a favorable and socioeconomically diverse association between PA energy expenditure (PAEE) (measured in metabolic equivalent task [MET]-min/week) and the prevalence of CMRF(s) among adults in China, but national representative analyses have been limited. 13 , 14 , 15 , 16 , 17 , 18 Although body weight is one of the key factors for physical activity expenditure in a population characterized by an obesity epidemic (in China), studies on PAEE/kg body weight are very limited, which could have been providing only a partial understanding of its correlation with CMRFs. Using data from the China Chronic Disease and Nutrition Surveillance (CCDNS) in 2015, we aimed to determine the association between PAEE/kg and the prevalence of CMRFs in Chinese adults aged 18–64 years.…”