Association of Two Indices of Insulin Resistance Marker with Abnormal Liver Function Tests: A Cross-Sectional Population Study in Taiwanese Adults

Kurniawan, Adi Lukas; Hsu, Chien‐Yeh; Chao, Jane C.-J.; Paramastri, Rathi; Lee, Hsiu-An; Jallow, Amadou Wurry

doi:10.3390/medicina58010004

Cited by 4 publications

(4 citation statements)

References 43 publications

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“…Ahn et al has shown TyG index consisting of lipid-related and glucose-related factors was a reliable marker of IR in the human body [ 39 ]. And, IR as a risk factor for CVD, it can lead to the development of CVD in both the general population and diabetes patients and predict the cardiovascular prognosis of patients with CVD [ 36 ]. Some studies have given the reason IR not only in atherogenesis but also in advanced plaque progression by promoting apoptosis of macrophages, endothelial cells, and vascular smooth muscle cells.…”

Section: Discussionmentioning

confidence: 99%

Predictive effect of triglyceride-glucose index on clinical events in patients with acute ischemic stroke and type 2 diabetes mellitus

Liu

Yang

et al. 2022

Cardiovasc Diabetol

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Background The triglyceride-glucose (TyG) index was significantly related to clinical outcome in patients with cardiovascular disease (CAD) and cerebrovascular disease (CVD). We aim to investigate the association between TyG index and clinical prognosis of acute ischemic stroke (IS) patients with type-2 diabetes mellitus (T2DM). Methods Among 19,604 patients with acute IS admitted to the China National Stroke Registry II (CNSRII), 3359 IS patients with T2DM were included in the cross-sectional analysis. The TyG index (calculated by ln [fasting triglycerides (mg/dL) × fasting glucose (mg/dL)/2]) was split into four quartiles. The outcomes included recurrent IS, all-cause death and poor outcome at 1 year were analyzed. The association between the TyG index and adverse cerebrovascular outcomes was assessed by proportional hazards regression analysis. Results During 1 year follow-up, recurrent IS, all-cause death and poor outcome occurred in 305 (9.08%), 229 (6.82%) and 443 (47.9%) cases, respectively. Multivariable Cox proportional hazards analyses showed that the risk of incident primary endpoints was associated with a higher TyG quartile. After adjustment for confounding factors, patients with a higher TyG index had an association with IS recurrence (adjusted hazard ratio, 1.41; 95% confidence interval, 0.97–2.03; P = 0.048) and all-cause death (adjusted hazard ratio, 1.70; 95% confidence interval, 1.062–2.74; P = 0.028), compared with those in the first quartile at 1 year time follow-up. In addition, there were interactions between TyG index and age (≥ 65), female, hypertensive agents, anticoagulant agents, statins and antidiabetic agents in subgroup analyses, especially patients without taken anticoagulant drugs were significantly related to IS recurrence, all-cause death and poor outcome (P = 0.003, P = 0.006 and P = 0.001, respectively). Conclusions TyG index is strongly related to the IS recurrence and all-cause death in acute IS patients with T2DM. This finding indicates that the TyG index might be a potential predictor of clinical outcome for acute IS patients with T2DM.

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Section: Discussionmentioning

confidence: 99%

Predictive effect of triglyceride-glucose index on clinical events in patients with acute ischemic stroke and type 2 diabetes mellitus

Liu

Yang

et al. 2022

Cardiovasc Diabetol

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“…Previous research has also shown a link between IR and liver function parameters. A study of Taiwanese adults found that those in the highest quintile of the TyG index had a higher risk of elevated AST, ALT and ALP than those in the median quintile [ 65 ]. A recent study of Chinese individuals found that IR was significantly associated with an increased risk of elevated ALT, AST and y‐glutamyl transferase (GGT) [ 64 ].…”

Section: Discussionmentioning

confidence: 99%

“…PCOS was defined according to the 2003 Rotterdam ESHRE/ASRM‐sponsored PCOS consensus workshop criteria 1 as endorsed by the most recent international evidence‐based guideline [ 34 ]. Elevated liver enzymes are considered as AST >35 IU/L and ALT >25 IU/L [ 35 , 36 ]. Hepatic steatosis index was defined as (HSI) = 8 × (ALT/AST) + BMI + (2, if diabetes mellitus) + (2, if female), with values <30 ruling out and values >36 ruling in steatosis [ 37 ].…”

Section: Methodsmentioning

confidence: 99%

Association Between Insulin Resistance Indices and Liver Function Parameters Among Women With Polycystic Ovary Syndrome

Saei Ghare Naz,

Mousavi,

Firouzi

et al. 2024

Endocrino Diabet & Metabol

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ObjectiveThis study aimed to investigate whether polycystic ovary syndrome (PCOS) status changes the association between insulin resistance (IR) indices and liver function parameters among women.MethodsThis is a cross‐sectional, population‐based study. We selected 1101 subjects aged ≥20 years from participants of Tehran Lipid and Glucose Study (TLGS). All of them had known the status of PCOS, and all variables were related to the IR indices and liver function parameters. The main outcome measures were TG/HDL‐C and triglyceride‐glucose (TyG) and liver function parameters (hepatic steatosis index [HSI], alanine transaminase [ALT] and aspartate transaminase [AST]).ResultIn the present study, there was no significant difference between the PCOS and the non‐PCOS regarding the presence of liver function abnormalities. A model adjusted by age and BMI showed that the upper tertile of TyG index was positively associated with high AST (OR = 3.04 [95% CI: 1.20–7.68], p < 0.05), high ALT (4.76 [3.07–7.36], p < 0.05) and high HSI (8.44 [1.82–39.17], p < 0.05). Although the history of diabetes had a positive impact on elevated AST (1.66 [1.15, 2.40], p < 0.05), the third tertile of TG/HDL‐C was associated with increased odds of elevated ALT (3.35 [2.21–5.06]) and HSI (6.55 [1.17–36.46]), whereas the second tertile of TG/HDL‐C (OR = 2.65, CI 95%: 1.74–4.03) was also positively associated with elevated ALT. PCOS had no significant association with elevated liver function tests.ConclusionThe highest tertile of TyG index and the TG/HDL‐C ratio as a surrogate of IR might play a role in detecting abnormalities of liver function parameters among women. However, PCOS status cannot change the association between IR and liver dysfunction.

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“…Contradictory results have been observed in some of them, but changed and elevated serum activities ALT and GGT, and more recently increased ALP, together with increased CRP levels and triglycerides as well a very-low density lipoprotein cholesterol, were significantly associated with incidence of T2D and development of different conditions of fatty liver [8]. The underlying mechanisms remain uncertain but it is assumed that genetic predisposition, age, gender, ethnicity and race, overweight and low-physical activity represent the main risk factors for development both disease, fatty liver and diabetes [9,10].…”

Section: Introductionmentioning

confidence: 93%

Association of Marker of Inflammation, Hepatic Enzymes and Lipid Profile in Type 2 Diabetes

Mandal¹

2022

RAD Conference Proceedings

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Type 2 diabetes mellitus (T2D) is a condition characterized by hyperglycemia as well as chronic inflammation, and is associated with disturbed lipids metabolism and impaired hepatic function. It is well known that the liver plays a key role in maintenance of normal glucose levels during the fasting and post prandial periods while C reactive protein as a marker of inflammation is produced in the liver. Altered lipoprotein levels and elevated hepatic enzymes have been identified as an independent risk factor for the development of many metabolic disorders including T2D. Aim of this study was to evaluate C-reactive protein (CRP) as well hepatic enzymes and to find their association with the lipid profile in non-treated T2D patients. Biochemical parameters, CRP, hepatic enzymes (alanine amino transferase, aspartate amino transferase, gamma-glutamyl transferase, and alkaline phosphatase) were measured by using VITROS 350 Chemistry System. Glycemic control parameters, lipid profile and liver enzymes were increased in diabetics and differed from control group (p<0.001). The significant association between CRP with HDL levels as well as association of ALT and GGT activity with HDL levels was observed in control group. Also, a negative association of GGT with VLDL levels was revealed in healthy subjects. In non-treated diabetics a negative significant association between AST and HDL levels as well as a positive association of AST and LDL levels was found while lack of association between lipid profile and other liver enzymes. Interestingly, in diabetes patients a negative association between CRP and AP levels was observed. These findings suggest that marker of inflammation (CRP), hepatic enzymes activities and impaired lipid metabolism may play an important role in pathogenesis of T2D and related complications.

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Association of Two Indices of Insulin Resistance Marker with Abnormal Liver Function Tests: A Cross-Sectional Population Study in Taiwanese Adults

Cited by 4 publications

References 43 publications

Predictive effect of triglyceride-glucose index on clinical events in patients with acute ischemic stroke and type 2 diabetes mellitus

Predictive effect of triglyceride-glucose index on clinical events in patients with acute ischemic stroke and type 2 diabetes mellitus

Association Between Insulin Resistance Indices and Liver Function Parameters Among Women With Polycystic Ovary Syndrome

Association of Marker of Inflammation, Hepatic Enzymes and Lipid Profile in Type 2 Diabetes

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