Increasing Prevalence of Helicobacter pylori Infection with Age: Continuous Risk of Infection in Adults Rather than Cohort Effect

Zanten, S. J. O. Veldhuyzen Van; Pollak, P. Timothy; Best, Linda; Bezanson, G.; Marrie, Thomas J.

doi:10.1093/infdis/169.2.434

Cited by 154 publications

(77 citation statements)

References 13 publications

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“…In developed countries, infection with H. pylori is said to occur in at most 1% of the adult population per year. [10][11][12] Seroconversion would have little effect on the relative magnitude of the odds ratios among different age-classes. Previous studies have shown that H. pylori can not survive in the stomach when atrophy of the gastric mucosa advances and intestinal metaplasia occurs.…”

Section: P<001 D)mentioning

confidence: 99%

“…Indeed, a previous study has shown that seroreversion does occur in healthy older subjects. 11) In gastric cancer patients, seroreversion due to a weakened immune reaction 15) or due to loss of infection 16,17) is also expected during the incubation period. Seroreversion may occur as a result of the natural progression of gastric cancer rendering the gastric mucosa inhospitable to H. pylori 18) or through weakening of the immune reaction, both of which may account for the observed stronger relationship between early gastric cancer and H. pylori in recent studies.…”

Section: P<001 D)mentioning

confidence: 99%

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Effect of Age on the Relationship between Gastric Cancer and Helicobacter pylori

Kikuchi

Nakajima

Kobayashi

et al. 2000

Japanese Journal of Cancer Research

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Helicobacter pylori is thought to be involved in the pathogenesis of gastric cancer, but the time point at which it produces its effects (critical time) is unknown. We measured the serum level of H. pylori antibody in 787 gastric cancer patients and 1007 controls aged 20 to 69. Odds ratios for different gastric cancer types and stages were determined for each 10-year age class. The overall odds ratio for gastric cancer decreased with age, being 7.0 for those aged 20-29, 14.5 for those aged 30-39, 9.1 for those aged 40-49, 3.5 for those aged 50-59, and 1.5 for those aged 60-69 (trend in odds ratios: P < < < <0.01). However, there was no such age-dependent trend for early diffuse-type cancer; the odds ratios were 12.6, 4.0, 7.2, 6.5, and 18.5 respectively (P = = = =0.29). Early cancer tended to show higher seroprevalence than advanced cancer, especially in older subjects. No significant difference in seroprevalence was observed between diffuse and intestinal cancers within each age-class. Seroreversion must have occurred in the time interval between the critical time and the diagnosis of the cancer, especially in older patients. The age-dependent relationship between H. pylori and gastric cancer may be due to seroreversion, which itself may be independent of age. This age-independence indicates that prolonged exposure to H. pylori does not increase the magnitude of its influence on gastric carcinogenesis. Possible mechanisms through which H. pylori exerts pathogenic effects are continuous inflammation in adulthood and/or irreversible damage to gastric mucosa in childhood or the teenage years. Key words: Gastric cancer -Helicobacter pylori -Age -Early diffuse-type cancerMany studies have shown that Helicobacter pylori is related to gastric cancer.1-3) While cancer prevention trials focusing on the eradication of H. pylori have already been started, the critical timeframe (critical time), during which it produces its carcinogenic effect, has not been identified yet. Identification of this critical time is important because eradication of H. pylori after this time would have no preventive effect on the incidence of gastric cancer.To begin to determine the critical time, we investigated the relationship between gastric cancer and H. pylori with respect to age. Previous studies on the relationship between smoking and lung cancer have shown that the longer the exposure to smoking, the greater the magnitude of its effect on the incidence of lung cancer. 4,5) In a previous study on H. pylori and gastric cancer, we found a high odds ratio of 13.3 for those under 40 years of age, 6) and a meta-analysis showed that the relationship is stronger in the younger population.7) However, other variables, such as geographic region and ethnicity, certainly affect the incidence of gastric cancer by age-class. 8,9) We sought to more clearly separate the influence of age from these other variables by taking a large sample from within a relatively well defined geographic and ethnic region, which is something that previous studies have la...

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Section: P<001 D)mentioning

confidence: 99%

Section: P<001 D)mentioning

confidence: 99%

Effect of Age on the Relationship between Gastric Cancer and Helicobacter pylori

Kikuchi

Nakajima

Kobayashi

et al. 2000

Japanese Journal of Cancer Research

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“…79,80 The prevalence of H. pylori in western countries has by now considerably decreased below 50%. 39,[81][82][83] A second criticism is that the prevalence of H. pylori is the same among men and women, whereas the incidence of gastric cancer is higher among men. 74 In reply, there is first of all some evidence that the prevalence of H. pylori may actually be higher among men than among women, which might account for part of the observed differences in gastric cancer incidence.…”

Section: Atrophy Metaplasia and Gastric Cancer: Prospective Studiesmentioning

confidence: 99%

Relationship between Helicobacter pylori, atrophic gastritis and gastric cancer

Kuipers

1998

Aliment Pharmacol Ther

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“…It has been reported that there is relationship between Helicobacter pylori infection and children's gastroenterologic disease, the most convincing evidence of the role of H. pylori in peptic ulcer disease is provided by studies showing that recurrence rate of ulcer is markely reduced by eradication of the bacteria from the gastric antrum [12][13][14][15] . Recent partly retrospective epidemiologic study in adults suggested that H. pylori infection mainly occurred during childhood [16][17][18] , and its actual colonization in gastric mucosa would be determined by many factors during childhood [19][20][21] . In the previous studies, we have demonstrated that the prevalence of H. pylori infection of children with gastrointestinal disease is high [22] .…”

Section: Introductionmentioning

confidence: 99%

Seroepidemiology ofHelicobacter pyloriinfection among asymptomatic Chinese children

Chun¹,

Chen²,

Jiang³

et al. 2000

WJG

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Increasing Prevalence of Helicobacter pylori Infection with Age: Continuous Risk of Infection in Adults Rather than Cohort Effect

Cited by 154 publications

References 13 publications

Effect of Age on the Relationship between Gastric Cancer and Helicobacter pylori

Effect of Age on the Relationship between Gastric Cancer and Helicobacter pylori

Relationship between Helicobacter pylori, atrophic gastritis and gastric cancer

Seroepidemiology ofHelicobacter pyloriinfection among asymptomatic Chinese children

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