Effect of Age on the Relationship between Gastric Cancer and <i>Helicobacter pylori</i>

Kikuchi, Shogo; Nakajima, Toshifusa; Kobayashi, Osamu; Yamazaki, Tatsuo; Kikuichi, Masahiro; Mori, Kiyoshi; Oura, Shinsuke; Watanabe, Hideaki; Nagawa, Hirokazu; Otani, Reiji; Okamoto, Naoyuki; Kurosawa, Michiko; Anzai, Haruyuki; Kubo, Takuji; Konishi, Toshiro; Futagawa, Shunji; Mizobuchi, Noboru; Kobori, Oichiro; Kaise, R; Sato, Tosiya; Inaba, Yutaka; Wada, Osamu

doi:10.1111/j.1349-7006.2000.tb01012.x

Cited by 43 publications

(54 citation statements)

References 30 publications

(27 reference statements)

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“…[5][6][7][8][9] No remarkable difference was found between analyses restricting subjects by H. pylori status, though the results are not shown. Therefore, the effect of smoking and drinking doses were evaluated with adjustment for H. pylori status, which differs from most studies to date.…”

Section: Discussionmentioning

confidence: 45%

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U‐shaped Effect of Drinking and Linear Effect of Smoking on Risk for Stomach Cancer in Japan

Kikuchi

Nakajima

Kobayashi

et al. 2002

Japanese Journal of Cancer Research

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A case-control study was conducted to evaluate the relationship between smoking or drinking doses and risk for stomach cancer, and to clarify whether the relationship is dose-dependent or U-shaped. Smoking dose was categorized as 0, 1-399, 400-799, or 800+ + + + cigarette-years, and drinking dose as 0, occasional/0.1-134.9, 135-1349.9, or 1350 + + + + alcohol-years (ml of pure alcohol intake per day multiplied by years of drinking). Helicobacter pylori status was determined by serology for adjustment. Using logistic regression, the adjusted effects of smoking and drinking doses on risk for stomach cancer were calculated for both genders. Among male subjects, the odds ratios (95% confidence intervals (

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Section: Discussionmentioning

confidence: 45%

“…Although it is known that Helicobacter pylori is a strong risk factor for stomach cancer, [5][6][7][8][9] few studies to date have evaluated the effect of smoking or drinking with consideration of H. pylori status.…”

mentioning

confidence: 99%

U‐shaped Effect of Drinking and Linear Effect of Smoking on Risk for Stomach Cancer in Japan

Kikuchi

Nakajima

Kobayashi

et al. 2002

Japanese Journal of Cancer Research

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“…H. pylori IgG antibodies were found in only 2% (0 -5) of men and 2% (0 -4) of women, and were significantly lower than the 62% (58-65) and 57% (53-60), respectively, in Japan. (17) Positive findings for the PG tests were 0% in both sexes, again significantly lower than the 23% (22-25) and 22% (20 -23) reported for Japanese people. (12) Smoking rates were rather higher for men in Semarang than in Japan but lower for women (Table 2).…”

Section: Resultsmentioning

confidence: 81%

Helicobacter pylori infection appears essential for stomach carcinogenesis: Observations in Semarang, Indonesia

Tokudome

Samsuria²,

Soeripto

et al. 2005

Cancer Science

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The gastric cancer incidence in Semarang, Indonesia, is exceedingly low: only approximately 1/100th of the level in Japan. To elucidate the reason, we carried out an ecological study recruiting 69 male and 102 female participants from the general populace in January 2005. Positive urea breath tests were 0% for both men and women, and Helicobacter pylori (H. pylori) IgG antibodies were found in 2% (0-5, 95% confidence interval) of men and 2% (0 -4) of women, significantly lower than the 62% (58-65) and 57% (53-60), respectively, in Japan. Furthermore, there were no positive findings with the pepsinogen tests in Semarang, again significant in comparison with the 23% (22-25) and 22% (20-23) in Japan. Variation in smoking levels and consumption of NaCl, vegetables and fruit were found, but not to an extent that would allow explanation of the major differences in gastric cancer incidence. We may conclude that the very low prevalence of H. pylori infection and thus chronic atrophic gastritis account for the rarity of stomach cancer in Semarang, Indonesia. (Cancer Sci 2005; 96: 873-875) S ince 2002, we have been conducting a collaborative epidemiologic appraisal of host and environmental factors for stomach and colorectal cancer in several South-east Asian countries. Ecological and case-control studies are now being carried out in Hanoi and Ho Chi Minh City, Vietnam; Khon Kaen, Thailand; and Yogyakarta and Semarang, Indonesia, in order to take advantage of the major variation in cancer incidence among these geographical areas and also with data for Japan. Stomach cancer incidence rates in Hanoi, Ho Chi Minh City, Khon Kaen, Yogyakarta and Semarang are approximately 1/2, 1/4, 1/10, 1/50 and 1/100 those prevailing in Japan, respectively: the annual age-adjusted incidence rates for Semarang were 0.6/10 5 for men and 0.3/10 5 for women during 1990-1999, and the respective figures for Japan in 1995 were 67/10 5 and 27/10 5 .(1,2)Gastric cancer may be caused by environmental or lifestyle risks, host genetic polymorphisms, as well as aging.(3) Many laboratory studies have pointed to roles for carcinogenic substances, including amine pyrolysate products and nitrosamines; however, grilled or barbecued meat and fish are categorized as possible risk factors in humans.(3) A probable risk factor for stomach cancer is salt or salty foods, which act synergistically with Helicobacter pylori (H. Pylori) infection in the development of stomach cancer in experimental animals (4) and humans. (5) Convincing preventive factors are vegetables and fruit and refrigeration, and a probable preventive factor is vitamin C. The International Agency for Research on Cancer (IARC) has concluded that gastric cancer is a smokerelated malignancy.(6) H. pylori is a definite carcinogen, (7)(8)(9) and is accepted to be a major factor for chronic atrophic gastritis (CAG), (5) a precursor lesion for stomach cancer.We here report the results of an ecological study of stomach cancer with reference to H. pylori infection and pepsinogen tests as a marker of CAG, ...

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“…The prevalence was generally lower in children than in adults [19,20], reflecting the decreasing trend of infection over the past decades. However, those previous reports may have some selection bias because they did not include all children of a target age and/or area with relatively low participation rates.…”

Section: Discussionmentioning

confidence: 99%

The administrative project of Helicobacter pylori infection screening among junior high school students in an area of Japan with a high incidence of gastric cancer

et al. 2017

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Objective Helicobacter pylori infection is a common chronic infection that is closely associated with gastric cancer, known to be decreasing worldwide. We set up an administrative project of screening examination for H. pylori infection in junior high school students in Akita Prefecture to investigate the current prevalence of H. pylori infection in childhood in an area where the incidence of gastric cancer is particularly high. Subjects and methods All students in their second or third year of junior high school (13 to 15 years old) in two cities in Akita Prefecture were recruited. First, a urine-based enzyme-linked immunosorbent assay for detection of H. pylori antibody was performed. Then, a 13 C-urea breath test ( 13 C-UBT) was carried out in students who tested positive on the urinary test. Written informed consent was obtained from all participants and their parents. Results A total of 1813 students were recruited in this study; 1765 (97.3%) students agreed to participate in this project and underwent a screening examination. Among 96 students (5.4%) testing positive for H. pylori on the initial screening examination, 90 (93.7%, 90/96) underwent a subsequent 13 C-UBT, and 85 (4.8%, 85/1765) were diagnosed as positive for H. pylori. Conclusions The current prevalence of H. pylori infection among students was low even in an area of Japan with a high incidence of gastric cancer.

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Effect of Age on the Relationship between Gastric Cancer and Helicobacter pylori

Cited by 43 publications

References 30 publications

U‐shaped Effect of Drinking and Linear Effect of Smoking on Risk for Stomach Cancer in Japan

U‐shaped Effect of Drinking and Linear Effect of Smoking on Risk for Stomach Cancer in Japan

Helicobacter pylori infection appears essential for stomach carcinogenesis: Observations in Semarang, Indonesia

The administrative project of Helicobacter pylori infection screening among junior high school students in an area of Japan with a high incidence of gastric cancer

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