Increasing Incidence of Ophthalmic Lymphoma in Denmark from 1980 to 2005

Sjö, Lene Dissing; Ralfkiær, Elisabeth; Prause, Jan Ulrik; Petersen, Jørgen Holm; Madsen, Jesper; Pedersen, Niels Tinggaard; Heegaard, Steffen

doi:10.1167/iovs.08-1768

Cited by 69 publications

(57 citation statements)

References 37 publications

(37 reference statements)

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“…This is in contrast to the most common ocular adnexal lymphoma subtype, extranodal marginal zone lymphoma, which appears to be relatively less frequently located in the lacrimal gland (Ferry et al 2007;Sjo et al 2008). However, in the present series, there was no difference regarding histological grading, growth pattern and translocation rate between the ocular adnexal region sites.…”

Section: Discussioncontrasting

confidence: 87%

“…This nation-based study represents the largest series published of unselected patients with ocular adnexal follicular lymphoma. The data confirm that follicular lymphoma is relatively rare, although it constitutes the second most common low-grade lymphoma subtype of this anatomical region (Coupland et al 2004;Ferry et al 2007;Sjo et al 2008).…”

Section: Discussionsupporting

confidence: 68%

“…Follicular lymphoma is relatively common in this region, accounting for 23% of all ocular adnexal lymphomas in the United States (Ferry et al 2007). In Western Europe and Asia, only 5-10% of all lymphomas in this anatomical region is follicular lymphoma (Coupland et al 2004;Meunier et al 2004;Sjo et al 2008). Although, ocular adnexal follicular lymphoma has been described to exhibit similar morphological and immunophenotypical features as nodal follicular lymphoma (Ferry et al 2007), the clinicopathological characteristics have not been evaluated in a nation-based study.…”

Section: Introductionmentioning

confidence: 99%

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Follicular lymphoma of the ocular adnexal region: A nation‐based study

Rasmussen

Ralfkiær

Prause

et al. 2014

Acta Ophthalmologica

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ABSTRACT.Purpose: To characterize the clinicopathological features of follicular lymphoma of the ocular adnexal region. Methods: Retrospective nation-based study of Danish patients with ocular adnexal follicular lymphoma from January 1st 1980 through December 31st 2009. Results: Twenty-four patients with ocular adnexal follicular lymphoma were identified. Fourteen (58%) of the patients were females. The median age was 63 years (range: 42-96 years). Eleven (46%) of the patients had primary ocular adnexal lymphoma, seven (29%) had an ocular adnexal lesion in conjunction with a concurrent systemic lymphoma and six patients (25%) presented with an ocular adnexal relapse. The most frequently affected sites were the lacrimal gland (38%) and the orbit (33%). Thirteen patients (54%) presented with Ann Arbor stage IE lymphoma, four (17%) had stage IIE, two patients (8%) stage IIIE, and five patients (21%) had stage IV lymphoma. Radiotherapy was primarily used in patients with primary lymphoma and those with a stage IE/IIE relapse (82%), while stage IIIE/IV lymphomas most frequently received alkylating chemotherapy (67%). Complete remission was observed in 19 of the patients (79%), but of these 11(58%) had a relapse. The 10-year overall survival for the entire cohort was 59%. The translocation t(14;18) was detected in 16 patients (16/24, 76%). Recurrence was only observed in patients with the t(14;18) (p = 0.05, log-rank). Conclusions: Ocular adnexal follicular lymphoma is more commonly found in elderly female patients. The lacrimal gland is relatively frequently involved. Radiotherapy is the treatment of choice for localized ocular adnexal follicular lymphoma providing a favourable prognosis for majority of patients.

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Section: Discussioncontrasting

confidence: 87%

Section: Discussionsupporting

confidence: 68%

Section: Introductionmentioning

confidence: 99%

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Follicular lymphoma of the ocular adnexal region: A nation‐based study

Rasmussen

Ralfkiær

Prause

et al. 2014

Acta Ophthalmologica

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“…lymphomas of the orbit, eyelids, conjunctiva, lacrimal gland and lacrimal sac) constitute 2% of all extranodal lymphomas (Freeman et al 1972) and are the most common malignant tumours of the orbit (Shields et al 2004). Likewise, lymphomas involving the conjunctiva are relatively common (Coupland et al 2004;Ferry et al 2007;Sjo¨et al 2008). Lymphomas involving these two sites are well described in the literature (Knowles & Jakobiec 1980;Bessell et al 1988;Esik et al 1996;Shields et al 2001;Martinet et al 2003;Meunier et al 2006).…”

Section: List Of Abbreviationsmentioning

confidence: 97%

“…Lacrimal gland lymphomas are also rare, representing 7-26% of ocular adnexal lymphomas (Jenkins et al 2003;Coupland et al 2004;Sjo¨et al 2008). However, 37% of all malignant tumours of the lacrimal gland are lymphomas (von Holstein et al 2012).…”

Section: List Of Abbreviationsmentioning

confidence: 99%

Diffuse large B‐cell lymphoma and mantle cell lymphoma of the ocular adnexal region, and lymphoma of the lacrimal gland: An investigation of clinical and histopathological features

Rasmussen

2013

Acta Ophthalmologica

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Diffuse large B‐cell lymphoma (DLBCL) and mantle cell lymphoma (MCL) constitute two distinct subtypes of non‐Hodgkin lymphoma (NHL) associated with considerable morbidity and mortality.Marked diversities with regard to molecular biology and clinical features are recognized in different subsets of the two lymphomas. Because these differences could be related to the location of the lymphoma, it is of interest to investigate the clinical and histopathological features of DLBCL and MCL involving the ocular adnexal region (i.e. the orbit, eyelids, conjunctiva, lacrimal gland and lacrimal sac). Similarly, the lacrimal gland is the only glandular structure within the orbit. Because the lacrimal gland represents an important part of the immunological system, it is of interest to investigate lymphomas involving this location with regard to clinical and histological characteristics.Purpose: To characterize the clinical and histopathological features of Danish patients with DLBCL of the ocular adnexal region between 1980 and 2009 and of Danish ocular adnexal MCL patients from 1980 to 2005. Furthermore, the aim of this PhD was to review all specimens from patients with lymphoma of the lacrimal gland in Denmark between 1975 and 2009 to determine the distribution of lymphoma subtypes of the lacrimal gland and to describe the clinicopathological features of these patients.Results: A total of 34 patients with DLBCL and 21 with MCL of the ocular adnexal region were identified. Twenty‐seven patients had lacrimal gland lymphoma, including four DLBCLs and three MCLs from studies I and II.Elderly patients predominated in all three groups, with median ages of 78, 75 and 69 years in the DLBCL, the MCL and the lacrimal gland lymphoma groups, respectively. MCL patients had a preponderance of males, whereas females prevailed among lacrimal gland lymphoma patients. The orbit was the most common site of involvement in DLBCL and MCL. Most DLBCL patients had unilateral involvement, while MCL patients had a high frequency of bilateral involvement. Similarly, localized lymphoma was relatively frequently seen in DLBCL patients in contrast to the predominance of disseminated lymphoma in the MCL group.The majority of lacrimal gland lymphomas were low grade, and the distribution of subtypes was as follows: extranodal marginal zone lymphoma, 10 (37%); follicular lymphoma, 5 (19%); DLBCL, 4 (15%); MCL, 3 (11%); chronic lymphocytic leukaemia/small lymphatic lymphoma, 2 (7%); and unclassified B‐cell lymphoma, 3 (11%).The overall survival rates at 3 and 5 years for the entire study group of DLBCL were 42% and 20%, whereas 58% and 22% of MCL patients were alive 3 and 5 years after the time of diagnosis. The 5‐year overall survival rate of lacrimal gland lymphoma patients was 70%.Concordant bone marrow involvement and the International Prognostic Index score were predictive factors for the overall survival in the DLBCL group in Cox regression analysis. Rituximab‐containing chemotherapy was associated with an improved survival rate in MCL patients.Conclusions: Diffuse large B‐cell lymphoma and MCL involving the ocular adnexal region and lymphoma of the lacrimal gland are prevalent among elderly patients. The overall prognosis in DLBCL and MCL was poor, whereas the prognosis for lacrimal gland lymphoma patients was relatively good. Concordant bone marrow involvement and the International Prognostic Index score were independent predictive factors for mortality in the DLBCL group. Chemotherapy containing rituximab significantly improved survival in the MCL group.

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Malignant Lymphoma of the Lacrimal Gland

Rasmussen¹

2011

Arch Ophthalmol

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To characterize the clinicopathologic features of lacrimal gland lymphoma. Methods: All cases of lacrimal gland lymphoma from January 1, 1975, through December 31, 2009, were retrieved from The Danish Registry of Pathology. Histologic specimens were reevaluated using a panel of monoclonal antibodies. Clinical files from all patients with confirmed lymphoma were collected. Results: Twenty-seven patients with lacrimal gland lymphoma were identified. Eight of the patients were men and 19 were women; the median (range) age was 69 (43-87) years. The distribution of lymphoma subtypes was as follows: extranodal marginal zone lymphoma, 10 (37%); follicular lymphoma, 5 (19%); diffuse large Bcell lymphoma, 4 (15%); mantle cell lymphoma, 3 (11%); chronic lymphocytic leukemia/small lymphatic lymphoma, 2 (7%); and unclassified B-cell lymphoma, 3 (11%). Twenty-two patients (81%) had stage I or II lym

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Increasing Incidence of Ophthalmic Lymphoma in Denmark from 1980 to 2005

Abstract: In the Danish population ophthalmic lymphoma consists primarily of orbital MALT lymphoma. Although it is a rare disease in mostly elderly patients, the incidence of ophthalmic lymphoma is increasing at a rapid pace.

Cited by 69 publications

References 37 publications

Follicular lymphoma of the ocular adnexal region: A nation‐based study

Follicular lymphoma of the ocular adnexal region: A nation‐based study

Diffuse large B‐cell lymphoma and mantle cell lymphoma of the ocular adnexal region, and lymphoma of the lacrimal gland: An investigation of clinical and histopathological features

Malignant Lymphoma of the Lacrimal Gland

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