Malignant Lymphoma of the Lacrimal Gland

Rasmussen, P

doi:10.1001/archophthalmol.2011.270

Cited by 51 publications

(53 citation statements)

References 24 publications

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“…Of these, 321 patients had primary carcinomas or sarcomas of the lacrimal gland and composed the cohort used in the analysis; the remaining 433 patients had lymphomas and were excluded from the remainder of the data analysis. 19 Of our selected cohort, 55.5% were males and 74.8% were white ( Table 1). The mean age at diagnosis was 57.7 years.…”

Section: Resultsmentioning

confidence: 99%

Epidemiology and Treatment of Lacrimal Gland Tumors

Clair

Arshi

Tajudeen

et al. 2014

JAMA Otolaryngol Head Neck Surg

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Section: Resultsmentioning

confidence: 99%

Epidemiology and Treatment of Lacrimal Gland Tumors

Clair

Arshi

Tajudeen

et al. 2014

JAMA Otolaryngol Head Neck Surg

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“…= B-cell lymphoma, unclassified; CEOP = cyclophosphamide, epirubicin, vincristine and prednisone; CHOP = cyclophosphamide, hydroxydaurubicin, vincristine and prednisone; CLL ⁄ SLL = chronic lymphocytic leukaemia ⁄ small lymphatic lymphoma; DLBCL = diffuse large B-cell lymphoma; EMZL = extranodal marginal zone lymphoma; FL = follicular lymphoma; LDH = lactate dehydrogenase; LG = lacrimal gland; MCL = mantle cell lymphoma; TNM = Tumour, Node, Metastasis. (Rasmussen et al 2011). a full clinical evaluation with up-todate imaging modalities, as defined earlier, was not possible for some of the patients. In these cases, the determination of whether they had primary or secondary lymphoma may be associated with some uncertainty.…”

Section: Clinical Datamentioning

confidence: 99%

Diffuse large B‐cell lymphoma and mantle cell lymphoma of the ocular adnexal region, and lymphoma of the lacrimal gland: An investigation of clinical and histopathological features

Rasmussen

2013

Acta Ophthalmologica

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Diffuse large B‐cell lymphoma (DLBCL) and mantle cell lymphoma (MCL) constitute two distinct subtypes of non‐Hodgkin lymphoma (NHL) associated with considerable morbidity and mortality.Marked diversities with regard to molecular biology and clinical features are recognized in different subsets of the two lymphomas. Because these differences could be related to the location of the lymphoma, it is of interest to investigate the clinical and histopathological features of DLBCL and MCL involving the ocular adnexal region (i.e. the orbit, eyelids, conjunctiva, lacrimal gland and lacrimal sac). Similarly, the lacrimal gland is the only glandular structure within the orbit. Because the lacrimal gland represents an important part of the immunological system, it is of interest to investigate lymphomas involving this location with regard to clinical and histological characteristics.Purpose: To characterize the clinical and histopathological features of Danish patients with DLBCL of the ocular adnexal region between 1980 and 2009 and of Danish ocular adnexal MCL patients from 1980 to 2005. Furthermore, the aim of this PhD was to review all specimens from patients with lymphoma of the lacrimal gland in Denmark between 1975 and 2009 to determine the distribution of lymphoma subtypes of the lacrimal gland and to describe the clinicopathological features of these patients.Results: A total of 34 patients with DLBCL and 21 with MCL of the ocular adnexal region were identified. Twenty‐seven patients had lacrimal gland lymphoma, including four DLBCLs and three MCLs from studies I and II.Elderly patients predominated in all three groups, with median ages of 78, 75 and 69 years in the DLBCL, the MCL and the lacrimal gland lymphoma groups, respectively. MCL patients had a preponderance of males, whereas females prevailed among lacrimal gland lymphoma patients. The orbit was the most common site of involvement in DLBCL and MCL. Most DLBCL patients had unilateral involvement, while MCL patients had a high frequency of bilateral involvement. Similarly, localized lymphoma was relatively frequently seen in DLBCL patients in contrast to the predominance of disseminated lymphoma in the MCL group.The majority of lacrimal gland lymphomas were low grade, and the distribution of subtypes was as follows: extranodal marginal zone lymphoma, 10 (37%); follicular lymphoma, 5 (19%); DLBCL, 4 (15%); MCL, 3 (11%); chronic lymphocytic leukaemia/small lymphatic lymphoma, 2 (7%); and unclassified B‐cell lymphoma, 3 (11%).The overall survival rates at 3 and 5 years for the entire study group of DLBCL were 42% and 20%, whereas 58% and 22% of MCL patients were alive 3 and 5 years after the time of diagnosis. The 5‐year overall survival rate of lacrimal gland lymphoma patients was 70%.Concordant bone marrow involvement and the International Prognostic Index score were predictive factors for the overall survival in the DLBCL group in Cox regression analysis. Rituximab‐containing chemotherapy was associated with an improved survival rate in MCL patients.Conclusions: Diffuse large B‐cell lymphoma and MCL involving the ocular adnexal region and lymphoma of the lacrimal gland are prevalent among elderly patients. The overall prognosis in DLBCL and MCL was poor, whereas the prognosis for lacrimal gland lymphoma patients was relatively good. Concordant bone marrow involvement and the International Prognostic Index score were independent predictive factors for mortality in the DLBCL group. Chemotherapy containing rituximab significantly improved survival in the MCL group.

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“…Its incidence increases with age. [4513] Usually, the MALT subtype of NHL affects other mucosal or epithelial tissues, such as the stomach, salivary gland, and thryroid gland and has an indolent course. The MALT lymphoma of the ocular adnexa usually affects women.…”

Section: Discussionmentioning

confidence: 99%

“…Secondary LGL by definition represents more diffuse and widespread disease and therefore may have a worse prognosis. [4514] The MALT lymphoma is frequently associated with genetic translocations t(11;18(q21;q21),[15] t(14:18)(q32:q31),[16] and trisomy 3. Some of the literature demonstrates an association with Chlamydia psittaci infection, although a study from south Florida has not found a great incidence of C. psittaci infection in their patient cohort.…”

Section: Discussionmentioning

confidence: 99%

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Lacrimal gland lymphoma: Role of radiation therapy

Townsend¹,

Turaka²,

Smith³

2012

Oman J Ophthalmol

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Background:To report the clinical and treatment outcome of patients with lacrimal gland lymphoma (LGL) treated with radiation therapy (RT) at Fox Chase Cancer Center, Philadelphia, PA, USA.Materials and Methods:Institutional review board approved retrospective chart review of eight patients and literature review.Results:The study patients included six males and two females with a mean age of 70 years (range 58-88 years). The mean follow-up period was 23 months (range 3–74 months). Four patients had mucosa-associated lymphoid tissue (50%) lymphoma and four patients had other non-Hodgkin's lymphoma variants. Four patients had bilateral disease (50%). Four patients had primary LGL (stages I-IIAE, 50%) and four had LGL as part of systemic lymphoma (stage IVAE, 50%). The median RT dose was 2987 cGy (range 2880–3015 cGy). All patients had complete response to RT with symptomatic relief. Minimal dry eye was seen in all patients. There were no late effects such as corneal ulcer, radiation retinopathy, maculopathy, papillopathy, or secondary neovascular glaucoma.Conclusions:RT alone is an extremely effective treatment in the curative management of localized LGL and provides durable, local control of secondary LGL.

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Malignant Lymphoma of the Lacrimal Gland

Cited by 51 publications

References 24 publications

Epidemiology and Treatment of Lacrimal Gland Tumors

Epidemiology and Treatment of Lacrimal Gland Tumors

Diffuse large B‐cell lymphoma and mantle cell lymphoma of the ocular adnexal region, and lymphoma of the lacrimal gland: An investigation of clinical and histopathological features

Lacrimal gland lymphoma: Role of radiation therapy

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