Increased visual dependence and otolith dysfunction with alcohol intoxication

Hafström, Anna; Modig, Fredrik; Karlberg, Mikael; Fransson, Per-Anders

doi:10.1097/wnr.0b013e328013e3eb

Cited by 27 publications

(27 citation statements)

References 20 publications

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“…Another explanation could be that the information provided by vision is distorted by alcohol intoxication effects on the vestibular system through visual-vestibular interactions. Hafström and colleagues reported that spatial orientation was increasingly more dependent on visual information with increasing alcohol intoxication (Hafstrom et al, 2007). Hence, if the CNS regards vision as a reliable source for spatial orientation even when the information is unreliable, there could be larger proportional destabilizing effects of alcohol intoxication with eyes open compared with eyes closed, as revealed in the present study.…”

Section: Visual Contribution Is Changed By Alcohol Intoxicationsupporting

confidence: 62%

“…Two participants from this group were excluded: one for not reaching intended BAC and one due to failing an otolith test (Hafstrom et al, 2007). The final study group consisted of 25 participants, 13 women and 12 men of mean age 25.1 years (range 19-41), mean height 1.75 meters (range 1.60-1.92), mean weight 68.8 kilograms (range 50.05-106.3) and mean BMI 22.2 (range 17.9-30.7).…”

Section: Methodsmentioning

confidence: 99%

“…Another aim was to evaluate the effects of alcohol on sensorimotor adaptive capabilities. This report is part of a larger project investigating the effects of alcohol intoxication on the visual (Hafstrom et al, 2007), oculo-motor and postural control systems .…”

Section: Introductionmentioning

confidence: 99%

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Blood alcohol concentration at 0.06 and 0.10% causes a complex multifaceted deterioration of body movement control

Modig

Fransson

Magnusson

et al. 2012

Alcohol

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Link to publication Citation for published version (APA): Modig, F., Fransson, P-A., Magnusson, M., & Patel, M. (2012). Blood alcohol concentration at 0.06 and 0.10% causes a complex multifaceted deterioration of body movement control. Alcohol, 46, 75-88. DOI: 10.1016/j.alcohol.2011 General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.• Users may download and print one copy of any publication from the public portal for the purpose of private study or research.• You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal AbstractAlcohol-related falls are recognized as a major contributor to the occurrence of traumatic brain injury. The control of upright standing balance is complex and comprises contributions from several partly independent mechanisms like appropriate information from multiple sensory systems and correct feedback and feedforward movement control. Analysis of multisegmented body movement offers a rarely used option for detecting the fine motor problems associated with alcohol intoxication.The study aims were: 1) to investigate whether alcohol intoxication at 0.06% and 0.10% blood alcohol concentration (BAC) affected linear body movement under unperturbed and perturbed standing; and 2) to investigate whether alcohol affected the ability for sensorimotor adaptation.Body movements were recorded in 25 participants (13 women and 12 men, mean age 25.1 years) at five locations (ankle, knee, hip, shoulder and head) during quiet standing and during balance perturbations from pseudorandom pulses of calf muscle vibration over 200s with eyes closed or open. Tests were performed at 0.00%, 0.06% and 0.10% BAC.The study revealed several significant findings: 1). An alcohol dose-specific effect; 2). A direction-specific stability decrease from alcohol intoxication; 3). A movement pattern change related to the level of alcohol intoxication during unperturbed standing and perturbed standing; 4). A sensorimotor adaptation deterioration with increased alcohol intoxication; and 5). That vision provided a weaker contribution to postural control during alcohol intoxication.Hence, alcohol intoxication at 0.06% and 0.10% BAC causes a complex multifaceted deterioration of human postural control.

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Section: Visual Contribution Is Changed By Alcohol Intoxicationsupporting

confidence: 62%

Section: Methodsmentioning

confidence: 99%

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Blood alcohol concentration at 0.06 and 0.10% causes a complex multifaceted deterioration of body movement control

Modig

Fransson

Magnusson

et al. 2012

Alcohol

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show abstract

“…The present study aimed to investigate alcohol-related effects on postural control and adaptation in the descending phase at exact, pre-specified, alcohol levels using the latest generation of precise alcohol breath analyzers. This report is part of a larger study concerning the effects of alcohol on vestibular [17], oculomotor [18] and postural systems [19,20].…”

Section: Introductionmentioning

confidence: 98%

Study I: Effects of 0.06% and 0.10% blood alcohol concentration on human postural control

Modig¹,

Patel²,

Magnusson³

et al. 2012

Gait & Posture

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“…Studies of ocular counterrolling have shown a small decrease in torsion after alcohol consumption (Diamond and Markham, 2008;Markham and Diamond, 2006). In contrast, there does not appear to be an effect of alcohol on the perception of subjective visual vertical (SVV) either during standard test administration (Zingler et al, 2003) or during eccentric rotation (Lindgren et al, 1998), though there tends to be an alcohol-related increase in visual field dependence on the rod and frame test (Hafstrom et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

The effect of alcohol on cervical and ocular vestibular evoked myogenic potentials in healthy volunteers

Rosengren

Weber

Hegemann

et al. 2014

Clinical Neurophysiology

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OBJECTIVE: We investigated the effect of alcohol on the cervical and ocular vestibular evoked myogenic potentials (cVEMPs and oVEMPs). As alcohol produces gaze-evoked nystagmus (GEN), we also tested the effect of nystagmus independent of alcohol by recording oVEMPs during optokinetic stimulation (OKS). METHODS: The effect of alcohol was tested in 14 subjects over multiple rounds of alcohol consumption up to a maximum breath alcohol concentration (BrAC) of 1.5‰ (mean 0.97‰).The effect of OKS was tested in 11 subjects at 5, 10 and 15deg/sec. RESULTS: oVEMP amplitude decreased from baseline to the highest BrAC level by 27% (range 5-50%, P<0.001), but there was no significant effect on oVEMP latency or cVEMP amplitude or latency. There was a significant negative effect of OKS on oVEMP amplitude (16%, P=0.006). CONCLUSIONS: We found a selective effect of alcohol on oVEMP amplitude, but no effect on the cVEMP. Vertical nystagmus elicited by OKS reduced oVEMP amplitude. SIGNIFICANCE: Alcohol selectively affects oVEMP amplitude. Despite the effects of alcohol and nystagmus, both reflexes were reliably recorded in all subjects and conditions. An absent response in a patient affected by alcohol or nystagmus indicates a vestibular deficit.

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Increased visual dependence and otolith dysfunction with alcohol intoxication

Cited by 27 publications

References 20 publications

Blood alcohol concentration at 0.06 and 0.10% causes a complex multifaceted deterioration of body movement control

Blood alcohol concentration at 0.06 and 0.10% causes a complex multifaceted deterioration of body movement control

Study I: Effects of 0.06% and 0.10% blood alcohol concentration on human postural control

The effect of alcohol on cervical and ocular vestibular evoked myogenic potentials in healthy volunteers

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