Blood alcohol concentration at 0.06 and 0.10% causes a complex multifaceted deterioration of body movement control

Abstract

Link to publication Citation for published version (APA): Modig, F., Fransson, P-A., Magnusson, M., & Patel, M. (2012). Blood alcohol concentration at 0.06 and 0.10% causes a complex multifaceted deterioration of body movement control. Alcohol, 46, 75-88. DOI: 10.1016/j.alcohol.2011 General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.• Users may download and print one copy of any publication from the public portal for the purpose of private study or research.• You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal AbstractAlcohol-related falls are recognized as a major contributor to the occurrence of traumatic brain injury. The control of upright standing balance is complex and comprises contributions from several partly independent mechanisms like appropriate information from multiple sensory systems and correct feedback and feedforward movement control. Analysis of multisegmented body movement offers a rarely used option for detecting the fine motor problems associated with alcohol intoxication.The study aims were: 1) to investigate whether alcohol intoxication at 0.06% and 0.10% blood alcohol concentration (BAC) affected linear body movement under unperturbed and perturbed standing; and 2) to investigate whether alcohol affected the ability for sensorimotor adaptation.Body movements were recorded in 25 participants (13 women and 12 men, mean age 25.1 years) at five locations (ankle, knee, hip, shoulder and head) during quiet standing and during balance perturbations from pseudorandom pulses of calf muscle vibration over 200s with eyes closed or open. Tests were performed at 0.00%, 0.06% and 0.10% BAC.The study revealed several significant findings: 1). An alcohol dose-specific effect; 2). A direction-specific stability decrease from alcohol intoxication; 3). A movement pattern change related to the level of alcohol intoxication during unperturbed standing and perturbed standing; 4). A sensorimotor adaptation deterioration with increased alcohol intoxication; and 5). That vision provided a weaker contribution to postural control during alcohol intoxication.Hence, alcohol intoxication at 0.06% and 0.10% BAC causes a complex multifaceted deterioration of human postural control.

Study I: Effects of 0.06% and 0.10% blood alcohol concentration on human postural control

“…However, when the posturography assessments were made, about 85 min after the participants finished drinking, almost all subjects were correctly aware of their state and level of intoxication. For further details about the subjective scores of feelings of drunkenness recorded during this study, see Modig et al [20].…”

“…The present study aimed to investigate alcohol-related effects on postural control and adaptation in the descending phase at exact, pre-specified, alcohol levels using the latest generation of precise alcohol breath analyzers. This report is part of a larger study concerning the effects of alcohol on vestibular [17], oculomotor [18] and postural systems [19,20].…”

Usual Alcohol Consumption and Risks for Nonfatal Fall Injuries in the United States: Results From the 2004–2013 National Health Interview Survey

“…Studies show that increased blood alcohol concentrations diminish motor coordination, impair judgment, and lengthen reaction time (Grant, Millar, & Kenny, 2000; Modig, Fransson, Magnusson, & Patel, 2012). In a meta-analysis of five studies, Taylor and colleagues (2010) concluded that unintentional-fall-injury risk increased linearly with acute alcohol consumption.…”

Efectos fisiológicos y psicológicos de una alta dosis de alcohol en hombres y mujeres jóvenes

“…Alcohol impairs the functioning of a variety of domains throughout the life cycle (Espert & Gadea, 2012), including brain development (Guerri & Pascual, 2010), attentional processing (Marinkovic, Rickenbacher, Azma, & Artsy, 2012), memory (Squeglia, Schweinsburg, Pulido, & Tapert, 2011), academic performance (Inglés, Torregrosa, Rodrí-guez-Marín, García del Castillo, Gázquez, García-Fernández & Delgado, 2013), and motor performance (Marczinski, Fillmore, Henges, Ramsey, & Young, 2012;Modig, Fransson, Magnusson, & Patel, 2012), and it alters physiological parameters, as well as anxiety (Vinader-Caerols, Monleón, Carrasco, & Parra, 2012).…”