Increased Serum Levels of IgA Antibodies to hsp70 Protein in Patients with Diabetes Mellitus: Their Relationship with Vascular Complications

Figueredo, A; Ibarra, José María Miralles; Rodrı́guez, Ana; Molino, Ángel; Concha, Emilio Gomez-de la; Fernández-Cruz, A; Patiño, R

doi:10.1006/clin.1996.0076

Cited by 25 publications

(14 citation statements)

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“…Since the G allele is associated with a lower HSP70 expression, it seems reasonable to expect a lower risk of cardiovascular events in this genotype group. Along this line, a previous study by other investigators showed that diabetic patients had elevated serum anti-HSP70 antibody levels [45], while patients with a longer duration of diabetes had higher serum HSP70 levels than those with shorter disease duration [46]. Taken together, our result suggests that HSP may play an important role in the background inflammatory state amongst stable PD patients.…”

Section: Discussionsupporting

confidence: 85%

Relationship between HSP70-2 A+1267G Polymorphism and Cardiovascular Events of Chinese Peritoneal Dialysis Patients

Poon¹,

Szeto²,

Kwan³

et al. 2014

Nephron Clin Pract

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Background: Heat shock proteins (HSPs) are expressed by cells in response to various environmental stresses. A single-nucleotide polymorphism A+1267G of the HSPA1B gene affects the expression of HSP70-2, with the A allele being protective against inflammatory conditions. We investigated the relation between the HSP A+1267G polymorphism and the clinical outcomes of Chinese peritoneal dialysis (PD) patients. Methods: We studied 347 new PD cases (181 males, age 56.6 ± 13.7 years). Genotyping was done by standard methods. Patients were followed for 40.5 ± 20.7 months for survival analysis. Results: For the entire cohort, there was no difference in the 5-year survival between genotype groups. However, there was a significant interaction between HSP polymorphism and diabetic status on the cardiovascular event-free survival. In patients without pre-existing diabetes, 5-year cardiovascular event-free survival of the GG/AG genotype group was significantly better than that of the AA genotype group (57.2 vs. 32.1%, p = 0.011). Conclusion: The G allele of the HSP70-2 A+1267G polymorphism confers survival advantages in non-diabetic PD patients. The role of HSP in the pathogenesis of cardiovascular disease in renal failure patients needs further investigation.

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Section: Discussionsupporting

confidence: 85%

Relationship between HSP70-2 A+1267G Polymorphism and Cardiovascular Events of Chinese Peritoneal Dialysis Patients

Poon¹,

Szeto²,

Kwan³

et al. 2014

Nephron Clin Pract

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show abstract

“…At the same time, Figueredo et al (1996) found that the mean titers of IgG and IgM class anti-HSP70 did not differ significantly between diabetic patients and nondiabetic control subjects. In contrast, the mean titer of anti-HSP70 IgA antibodies was significantly higher in diabetic sera than in the control in both types of diabetes.…”

Section: Discussionmentioning

confidence: 81%

Anti-heat shock protein 70 autoantibody epitope changes and BD091 promotes atherosclerosis in rats

Leng¹,

Zhan²,

Wang³

et al. 2010

Cell Stress and Chaperones

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It has been previously reported that the plasma levels of autoantibodies against heat shock protein 70 (HSP70) are elevated in atherosclerosis. The aim of the present study was to elucidate whether anti-HSP70 antibodies are involved in the pathogenesis of atherosclerosis. To determine this, we chose rats as an atherosclerosis model. Titers of plasma anti-HSP70 autoantibody were determined by ELISA. After the intravenous administration of antibody into the tail, the damaged areas of aorta were stained with Evans Blue, atheromatous plaque were stained by Oil Red O, and then they were measured and quantified with AxioVision computer software. The number of macrophages (M 6 ), smooth muscle cells (SMCs), and T cells were determined by immunocytochemistry. The level of anti-HSP70 IgG1 antibody was apparently increased in the AS group at the tenth week, and one hybridoma of HSP70 antibody (BD091, IgG1, recognizing C-terminal) had the same binding epitope as plasma anti-HSP70 autoantibodies. After intravenous administration, the lesion area of aorta with BD091 was significantly larger than those of IgG mouse and SPA-810. Moreover, injection of BD091 resulted in significant endothelium damage, followed by a greater accumulation of M 6 , T cells, and SMCs in lesions than in the control. In conclusion, BD091 reaction with HSP70 expressed on arterial endothelial cells inducing endothelium damage triggers the inflammatory response in the vessel wall that accelerates atherosclerosis in rats. BD091 shares the same binding epitope with HSP70 autoantibodies. These data indicated that a specific epitope of anti-HSP70 autoantibody participated in the pathogenesis of atherosclerosis.

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“…Mean serum IgA in type 2 diabetics was, however, significantly higher than matched controls. This result suggested a possible role of anti-HSP70 IgA in the pathogenesis of the vascular complications in diabetes mellitus [202].…”

Section: Hsp and Risk Factors Of Atherosclerosismentioning

confidence: 76%

Heat Shock Proteins and Cardiovascular Disease

Zilaee¹,

Ferns²,

Ghayour‐Mobarhan³

2014

Advances in Clinical Chemistry

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Increased Serum Levels of IgA Antibodies to hsp70 Protein in Patients with Diabetes Mellitus: Their Relationship with Vascular Complications

Cited by 25 publications

References 0 publications

Relationship between HSP70-2 A+1267G Polymorphism and Cardiovascular Events of Chinese Peritoneal Dialysis Patients

Relationship between HSP70-2 A+1267G Polymorphism and Cardiovascular Events of Chinese Peritoneal Dialysis Patients

Anti-heat shock protein 70 autoantibody epitope changes and BD091 promotes atherosclerosis in rats

Heat Shock Proteins and Cardiovascular Disease

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