Relationship between HSP70-2 A+1267G Polymorphism and Cardiovascular Events of Chinese Peritoneal Dialysis Patients

Abstract

Background: Heat shock proteins (HSPs) are expressed by cells in response to various environmental stresses. A single-nucleotide polymorphism A+1267G of the HSPA1B gene affects the expression of HSP70-2, with the A allele being protective against inflammatory conditions. We investigated the relation between the HSP A+1267G polymorphism and the clinical outcomes of Chinese peritoneal dialysis (PD) patients. Methods: We studied 347 new PD cases (181 males, age 56.6 ± 13.7 years). Genotyping was done by standard methods. Patients were followed for 40.5 ± 20.7 months for survival analysis. Results: For the entire cohort, there was no difference in the 5-year survival between genotype groups. However, there was a significant interaction between HSP polymorphism and diabetic status on the cardiovascular event-free survival. In patients without pre-existing diabetes, 5-year cardiovascular event-free survival of the GG/AG genotype group was significantly better than that of the AA genotype group (57.2 vs. 32.1%, p = 0.011). Conclusion: The G allele of the HSP70-2 A+1267G polymorphism confers survival advantages in non-diabetic PD patients. The role of HSP in the pathogenesis of cardiovascular disease in renal failure patients needs further investigation.

Circulating Advanced Glycation Endproducts and Long-Term Risk of Cardiovascular Mortality in Kidney Transplant Recipients

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Genetic Polymorphisms and Peritoneal Membrane Function

“…The majority of studies we reviewed did not include these data. Some showed a positive correlation between gene polymorphism and protein level (19,20,22,32,37), whereas others looked and did not find a correlation (22,25,39).…”

The role of heat shock proteins in the pathogenesis of some components of metabolic syndrome

“…выявили, что определенные аллельные варианты полиморфного маркера +190G/C в гене HSPA1A ассоциированы с повышенным риском развития острого коронарного синдрома у людей, имеющих отличающиеся от здоровых доноров уровни анти-HSP70-антител [41]. В другом исследовании получены достоверные данные, что пятилетняя выживаемость без сердечно-сосудистых событий, после перенесенной почечной патологии группы пациентов с генотипами GG и AG полиморфного маркера +1267A/G гена HSPA1B была значительно лучше, чем у группы с генотипами АА позволяет сделать вывод о возможной ассоциации аллельного варианта АА полиморфного маркера +1267A/G гена HSPA1B с наличием сердечно-сосудистых осложнений у пациентов [42].…”