Genetic Polymorphisms and Peritoneal Membrane Function

Siddique, Imad; Brimble, K. Scott; Walkin, Louise; Summers, Angela; Brenchley, Paul; Herrick, Sarah E.; Margetts, Peter J.

doi:10.3747/pdi.2014.00049

Cited by 12 publications

(10 citation statements)

References 40 publications

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“…Several studies on drainage biomarkers, including CA125 and IL-6, are currently underway to assess peritoneal function. 29,30 In the present study, adiponectin was a significant predictive factor of D/P and D/D 0 ratios, whereas no correlation was found between adiponectin and BMI. Thus, adipocytes in the peritoneum and visceral fat may affect peritoneal function.…”

Section: Discussioncontrasting

confidence: 69%

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Association of adipocytokines with peritoneal function

et al. 2020

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Background: Preservation of peritoneal function is crucial for the continuation of peritoneal dialysis (PD). A previous study suggested that blood cholesterol is involved in the preservation of peritoneal function; therefore, we determined whether adipocytokines can predict peritoneal function preservation. Methods: Eighty patients were enrolled. Serum adiponectin, leptin, apelin, various blood components, and estimated glomerular filtration rate (eGFR) (mL/min/m2) were measured. In addition, the duration of PD, presence or absence of peritonitis and diabetes mellitus, body mass index, urine output, peritoneal Kt/ V, renal Kt/ V, weekly Kt/ V, peritoneal creatinine clearance rate (CCr), renal CCr, weekly CCr, use or nonuse of statin products, dialysate volume, glucose exposure, and use or nonuse of icodextrin dialysate were assessed. Peritoneal equilibration tests were performed at 6-month intervals, and dialysate-to-plasma [D/P] ratio and glucose uptake ratio [D/D0] were measured. Associations of the baseline values and their percent changes with various adipocytokines and test items were evaluated. Results: Multiple regression analyses identified adiponectin ( p = 0.0392, p = 0.0348) as a significant predictive factor of D/P and D/D0 ratios. eGFR was identified as a significant predictive factor ( p = 0.015) of percent change in the D/P ratio. Apelin ( p = 0.0484), high-density lipoprotein cholesterol ( p = 0.0066), dialysate volume ( p = 0.0223), and urine output ( p = 0.0020) were identified as factors affecting the duration of PD. Conclusions: Adipocytokines are a predictive factor of peritoneal function and the duration of PD in patients undergoing PD.

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Section: Discussioncontrasting

confidence: 69%

“…Several studies on drainage biomarkers, including CA125 and IL-6, are currently underway to assess peritoneal function. 29,30…”

Section: Discussionmentioning

confidence: 99%

Association of adipocytokines with peritoneal function

et al. 2020

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“…In particular, baseline plasma levels of C-reactive protein or the rates of peritoneal infection during the first year were not discriminative for this purpose. Previous studies have disclosed associations among several genetic polymorphisms, on one hand, and both baseline small solute transport characteristics and their evolution in time, on the other (21). The relevance of genetic factors for the time course of incident UFF awaits further clarification.…”

Section: Discussionmentioning

confidence: 99%

Analysis of Ultrafiltration Failure Diagnosed at the Initiation of Peritoneal Dialysis with the Help of Peritoneal Equilibration Tests with Complete Drainage at Sixty Minutes. A Longitudinal Study

et al. 2016

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“…IL-6 is secreted by mesothelial cells after induction by IL-1ß and TNF-α (Topley et al., 1993). Individual differences in dialysate IL-6 concentrations have been linked to genetic polymorphisms (Siddique et al., 2015). In vitro and in mice, IL-6 was linked to VEGF production and thus angiogenesis via STAT3 and SP4 transcriptional factors (Catar et al., 2017); effluent IL-6 and VEGF concentrations are correlated (Pecoits-Filho et al., 2002).…”

Section: Molecular Mechanisms Of Pd-induced Peritoneal Transformationmentioning

confidence: 99%

Biocompatible Peritoneal Dialysis: The Target Is Still Way Off

Bartošová

Schmitt

2019

Front. Physiol.

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Peritoneal dialysis (PD) is a cost-effective, home-based therapy for patients with end-stage renal disease achieving similar outcome as compared to hemodialysis. Still, a minority of patients only receive PD. To a significant extend, this discrepancy is explained by major limitations regarding PD efficiency and sustainability. Due to highly unphysiological composition of PD fluids, the peritoneal membrane undergoes rapid morphological and long-term functional alterations, which limit the treatment and contribute to adverse patient outcome. This review is focused on the peritoneal membrane ultrastructure and its transformation in patients with kidney disease and chronic PD, underlying molecular mechanisms, and potential systemic sequelae. Current knowledge on the impact of conventional and second-generation PD fluids is described; novel strategies and innovative PD fluid types are discussed.

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Genetic Polymorphisms and Peritoneal Membrane Function

Abstract: There is evidence that characteristics of the peritoneal membrane and clinical outcomes for PD patients have genetic determinants. The most consistent association was between IL-6 gene polymorphisms and peritoneal membrane solute transport.

Cited by 12 publications

References 40 publications

Association of adipocytokines with peritoneal function

Association of adipocytokines with peritoneal function

Analysis of Ultrafiltration Failure Diagnosed at the Initiation of Peritoneal Dialysis with the Help of Peritoneal Equilibration Tests with Complete Drainage at Sixty Minutes. A Longitudinal Study

Biocompatible Peritoneal Dialysis: The Target Is Still Way Off

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