Increased Serum IgM and IgG in the Multiple Evanescent White-Dot Syndrome

Chung, Yu-Mei; Yeh, Tse-Shiang; Liu, Jorn‐Hon

doi:10.1016/0002-9394(87)90016-x

Cited by 35 publications

(12 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Because MEWDS has an acute onset, and is sometimes preceded by "flu-like" illness, a virus infection seems to be involved in the etiology of this disease. Chung et al 35 reported an increased serum level of total IgM and IgG during the acute phase of MEWDS. More recently, Gass 36 has hypothesized that an infectious agent invading the retinal photoreceptors from the ora serrata or peripapillary region may be responsible for the visual field defect in these patients.…”

Section: Discussionmentioning

confidence: 98%

High Prevalence of Myopia in Japanese Patients with Multiple Evanescent White Dot Syndrome

Asano

Kondo

et al. 2004

Jpn J Ophthalmol

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 98%

High Prevalence of Myopia in Japanese Patients with Multiple Evanescent White Dot Syndrome

Asano

Kondo

et al. 2004

Jpn J Ophthalmol

View full text Add to dashboard Cite

show abstract

“…We found evidence of bilaterality in only two patients based on ICGA and en face OCT imaging. Previous reports have described bilaterality, 1,4,[7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22] although the involvement of the second eye was mild. Li and Kishi 19 performed functional tests such as multifocal electroretinogram and full-field electroretinogram, proving bilateral dysfunction of photoreceptors in most of the MEWDS cases they studied.…”

Section: Discussionmentioning

confidence: 99%

“…To date, at least 22 cases of bilateral involvement have been described with no apparent difference from unilateral cases. 1,4,[7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22] Secondary choroidal neovascularization has been reported, 23 but only one case was described with choroidal neovascularization secondary to a typical MEWDS clinical presentation. 24 Recurrent episodes (one or more) have also been reported in 12 cases of MEWDS.…”

mentioning

confidence: 99%

Expanded Clinical Spectrum of Multiple Evanescent White Dot Syndrome With Multimodal Imaging

Marsiglia

Gallego-Pinazo

Souza

et al. 2016

Retina

View full text Add to dashboard Cite

Purpose: To evaluate and characterize multiple evanescent white dot syndrome abnormalities with modern multimodal imaging modalities.Methods: This retrospective cohort study evaluated fundus photography, fluorescein angiography, indocyanine green angiography, optical coherence tomography, enhanced depth imaging optical coherence tomography, short-wavelength autofluorescence, and near-infrared autofluorescence.Results: Thirty-four multiple evanescent white dot syndrome patients with mean age of 28.7 years were studied (range, 14-49 years). Twenty-six patients were women, and eight were men. Initial mean visual acuity was 0.41 logMAR. Final mean visual acuity was 0.03 logMAR. Fluorescein angiography shows a variable number of mid retinal early fluorescent dots distributed in a wreathlike pattern, which correlate to fundus photography, fundus autofluorescence, and indocyanine green angiography. Indocyanine green angiography imaging shows the dots and also hypofluorescent, deeper, and larger spots, which are occasionally confluent, demonstrating a large plaque of deep retinal hypofluorescence. Optical coherence tomography imaging shows multifocal debris centered at and around the ellipsoid layer, corresponding to the location of spots seen with photography, indocyanine green angiography, and fluorescein angiography. Protrusions of the hyperreflectant material from the ellipsoid layer toward the outer nuclear layer correspond to the location of dots seen with photography, indocyanine green angiography, and fluorescein angiography.Conclusion: Multimodal imaging analysis of the retina in patients with multiple evanescent white dot syndrome shows additional features that may help in the diagnosis of the disease and in further understanding its etiology. Multiple evanescent white dot syndrome is predominantly a disease of the outer retina, centered at the ellipsoid zone, but also involving the interdigitation zone and the outer nuclear layer.RETINA 36: [64][65][66][67][68][69][70][71][72][73][74] 2016

show abstract

“…The etiology remains uncertain and there is no definite evidence of systemic involvement, although an infection is suggested as MEWDS is preceded by a flu-like disease and elevated IgM and IgG levels in some patients [3]. MEWDS is characterized by multiple discrete white dots located at the level of the outer retina or the retinal pigment epithelium (RPE).…”

Section: Introductionmentioning

confidence: 99%