Multifocal ERG in multiple evanescent white dot syndrome

Chan

Survey of Ophthalmology

et al. 2007

Abstract. Multifocal electroretinography (mfERG) is an investigation that can simultaneously measure multiple electroretinographic responses at different retinal locations by cross-correlation techniques. mfERG therefore allows topographic mapping of retinal function in the central 40--50 of the retina. The strength of mfERG lies in its ability to provide objective assessment of the central retinal function at different retinal areas within a short duration of time. Since the introduction of mfERG in 1992, mfERG has been applied in a large variety of clinical settings. This article reviews the clinical applications of mfERG based on the currently available evidence. mfERG has been found to be useful in the assessment of localized retinal dysfunction caused by various acquired or hereditary retinal disorders. The use of mfERG also enabled clinicians to objectively monitor the treatment outcomes as the changes in visual functions might not be reflected by subjective methods of assessment. By changing the stimulus, recording, and analysis parameters, investigation of specific retinal electrophysiological components can be performed topographically. Further developments and consolidations of these parameters will likely broaden the use of mfERG in the clinical setting.

Section: Other Acquired Retinopathy Multiple Evanescent White Dot Synmentioning

confidence: 94%

Section: Other Acquired Retinopathy Multiple Evanescent White Dot Synmentioning

confidence: 99%

Section: Other Acquired Retinopathy Multiple Evanescent White Dot Synmentioning

confidence: 99%

See 1 more Smart Citation

The Clinical Applications of Multifocal Electroretinography: A Systematic Review

Chan

Survey of Ophthalmology

et al. 2007

Arquivos Brasileiros De Oftalmologia

“…The relationship between MFC and MEWDS may indicate a common etiological factor (16) . In these cases, multifocal electroretinogram can help to differentiate MFC from MEWDS, with deep wave depression in MFC and an initial focal loss in MEWDS, followed by full recovery of retinal function at about 7-14 days (24,25) .…”

Section: Discussionmentioning

confidence: 99%

Evaluation of MEWDS-like lesions with fluorescein angiography and its frequency at an ophthalmic emergency department in Rio de Janeiro

Dias

Morizot

2015

Avaliação de lesões com as características MEWDS ao exame de angiografia fluoresceínica e sua prevalência em serviço de emergência oftalmológica no Rio de Janeiro Results: Among the 6,111 angiographies analyzed, 15 MEWDS cases were detected; the patients ranged in age from 13 to 42 years old, and the male/female ratio was 60% to 40% (nine male and six female). The most common FA aspects included hyperfluorescent dots, dots and spots in the retinal mid-periphery, and foveal granularity in 46% of the cases. Conclusions: MEWDS has a good prognosis, with spontaneous involution, which makes it difficult to diagnose because of the delayed access to ophthalmological assistance, in special FA examination, which highlights the lesions. This study was possible due to the quick access facility at a private ophthalmic emergency department and examination by an experienced ophthalmologist, along with complementary diagnosis by FA and better perception of the patients, thus ensuring good prognosis.

“…Such lesions varied in size from 50 to 500 μm in diameter [42]. Full-field and multifocal electroretinograms disclose dysfunction at the photoreceptors level [43,44]. A typical OCT finding is the disruption of the photoreceptor inner/outer segment junction line which can recover along with the resolution of the disease [45].…”

Section: Multiple Evanescent White Dot Syndromementioning

confidence: 99%

Antivascular Endothelial Growth Factors for Inflammatory Chorioretinal Disorders

Parodi

Iacono

Verbraak³

et al. 2010

Anti-Vegf

Macular edema (ME) and choroidal neovascularization (CNV) can complicate the course of several inflammatory chorioretinal diseases, leading to a severe visual function impairment. The most frequently involved clinical entities include for example multifocal choroiditis, presumed ocular histoplasmosis syndrome, Beçhet's disease, multiple evanescent white dot syndrome, birdshot chorioretinopathy, acute multifocal posterior placoid pigment epitheliopathy, serpiginous choroiditis, and persistent placoid maculopathy. Results that have reported on antivascular endothelial growth factor (anti-VEGF) treatment in uveitic patients with CNV or ME have demonstrated positive results in many cases. However, bearing in mind that it has been proven impossible to perform randomized clinical trials with anti-VEGF in uveitic patients with CNV or ME, further studies with longer follow-ups are necessary to assess the value of this therapeutic approach.