Increased Production of Antioxidative Sesaminol Glucosides from Sesame Oil Cake through Fermentation by<i>Bacillus circulans</i>Strain YUS-2

Ohtsuki, Takashi; Akiyama, Junko; Shimoyama, Takao; Yazaki, S. C.; Ui, Sadaharu; Hirose, Yuko; Mimura, Akio

doi:10.1271/bbb.67.2304

Cited by 24 publications

(12 citation statements)

References 8 publications

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“…Similarly, Kang et al [17] reported that SG-containing, defatted sesame flour inhibits lipid peroxidation in hypercholesterolemic rabbits. Furthermore, in in vitro experiments, these compounds display free radical scavenging activity [14,[18][19][20]. In previous study, we also reported that SG has a protective effect against Ab-and scopolamine-induced cognitive dysfunction [21,22], and we have demonstrated an inhibitory effect on the lipopolysaccharide (LPS)-induced inflammatory response in astrocytes [23].…”

Section: Introductionmentioning

confidence: 76%

Sesaminol Glucosides Protect β-Amyloid Induced Apoptotic Cell Death by Regulating Redox System in SK-N-SH Cells

Ahn

Kim

et al. 2011

Neurochem Res

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We have investigated the neuroprotective effect of sesaminol glucosides (SG) in SK-N-SH cells. SG prevented apoptotic cell death induced by Aβ₂₅₋₃₅. In parallel, SK-N-SH cells exposed to Aβ₂₅₋₃₅ underwent oxidative stress as shown by the elevated level of intracellular ROS, lipid peroxidation, and 8-hydroxy-2'-deoxyguanosine (8-OHdG) formation, which were effectively suppressed by SG treatment. Furthermore, SG reversed the activities of catalase and glutathione peroxidase, and restored intracellular GSH levels in Aβ₂₅₋₃₅ challenged SK-N-SH cells. In addition, SG inhibited not only Aβ₂₅₋₃₅-induced apoptotic features including cleavage of poly(ADP-ribose) polymerase, activation of caspase-3, and activation of caspase-9, but also elevated Bax/Bcl-2 ratio in SK-N-SH cells treated with Aβ₂₅₋₃₅. It was also observed that Aβ₂₅₋₃₅ stimulated the phosphorylation of mitogen-activated protein kinases (MAPKs), including extracellular protein regulated protein kinase (ERK), c-Jun N-terminal kinase (JNK), and p38 MAP kinase. SG inhibited phosphorylation of the JNK, ERK and p38 MAP kinase. These results suggest that SG has a protective effect against Aβ₂₅₋₃₅-induced neuronal apoptosis, possibly through scavenging oxidative stress and regulating MAPKs signaling pathways.

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Section: Introductionmentioning

confidence: 76%

Sesaminol Glucosides Protect β-Amyloid Induced Apoptotic Cell Death by Regulating Redox System in SK-N-SH Cells

Ahn

Kim

et al. 2011

Neurochem Res

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“…However, several OCs have low protein content and are considered non-edible oil cakes. Thus, OCs can be used in other applications, such as the production of antibiotics and biopesticides (Kota and Sridhar, 1999;Sircar et al, 1998) and other biochemicals (Ohtsuki et al, 2003), in the production of mushrooms (Bano et al, 1993), as a bio-control agent (Khan and Saxena, 1997), * Corresponding author. Fax: +351253604429.…”

Section: Introductionmentioning

confidence: 99%

Optimization of lipase production by Aspergillus ibericus from oil cakes and its application in esterification reactions

Oliveira

Souza

Peclat

et al. 2017

Food and Bioproducts Processing

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Due to the actual emphasis in revalorization of agro-industrial wastes and cost reduction of enzymes production, this work aimed the optimization of lipase production from different oil cakes (OCs) produced in Brazil, by solid-state fermentation using Aspergillus ibericus MUM 03.49 and the application of the produced lipase in hydrolysis and esterification reactions. Higher lipase production was obtained using palm kernel oil cake (PKOC), yielding 127 ± 17 U/g of lipase (per mass of dry substrate). Through SSF optimization, using PKOC mixed with sesame oil cake (SOC) in a ratio of 0.45 g of PKOC per g total substrate at 57% moisture content (MC), a production of 460 ± 38 U/g of lipase was obtained after 6 days of fermentation. The obtained lipase was used in hydrolysis reactions, where it was observed higher production in short-chain triacylglycerols (TAGs) substrates. Also, it was applied in esterification reactions, where the formation of butyl decanoate using 5% (w/v) of biocatalyst was the most efficient. SSF of PKOC and SOC is a low cost competitive process to obtain A. ibericus lipase that can be used in aroma esters production, with application in the food industry.

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“…It is formed from sesamolin during sesame seed roasting 6, 7 and heating or refining operations (i.e., acid‐activated clay bleaching) 8–10. Among the lignans from sesame seeds, sesaminol, and its isomers were shown to have the most potent antioxidative activity in vitro experimental system, having higher antioxidative activity than α‐tocopherol and BHT 11. Sesaminol played the protective role against oxidative damage of human low‐density lipoprotein (LDL) in vitro by inhibiting the Cu 2+ ‐induced lipid peroxidation in LDL in a dose‐dependent response 12, and also can effectively increase the availability of tocopherols in biological systems and have the potentiality to inhibit oxidative damages in DNA caused in vivo system 13.…”

Section: Introductionmentioning

confidence: 99%

A novel conversion of sesamolin to sesaminol by acidic cation exchange resin

Huang

Song

Zhang

et al. 2012

Euro J Lipid Sci & Tech

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Sesame (Sesamum indicum L.) seed and its oil contain abundant lignans, including sesamin, sesamolin, sesamol, sesaminol, and their glycosides. In the present study, a novel reaction pathway, using an anhydrous solvent system, cation exchange resin catalyst, and HPLC for detection, was employed for the conversion of sesamolin into sesaminol. Under optimal conditions of 5 mL toluene, 908C, initial sesamolin concentration of 6 mM, and catalyst dosage of 16.66 g/mmol of sesamolin, a 75.0% yield of sesaminol was achieved. The reaction mechanism was inferred to be that of a Friedel-Crafts reaction, with the catalyst showing remarkable catalytic activity and producing only slightly decreased yield after reuse in five subsequent batches. Owing to excellent reusability, low cost, and ready availability, this catalyst provides a very satisfactory option for converting sesamolin to sesaminol.Practical applications: Sesaminol is a potential natural antioxidant for use as a food additive and in medicinal applications, but it is a naturally occurring trace compound, and could be transformed from sesamolin under proper, specific conditions. The cation exchange resin 732 provides a satisfactory option for catalyzing the conversion of sesamolin into sesaminol. This suggests encouraging prospects for practical or industrial applications utilizing its notable catalytic performance, reusability, low cost, and easy availability.

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Increased Production of Antioxidative Sesaminol Glucosides from Sesame Oil Cake through Fermentation byBacillus circulansStrain YUS-2

Cited by 24 publications

References 8 publications

Sesaminol Glucosides Protect β-Amyloid Induced Apoptotic Cell Death by Regulating Redox System in SK-N-SH Cells

Sesaminol Glucosides Protect β-Amyloid Induced Apoptotic Cell Death by Regulating Redox System in SK-N-SH Cells

Optimization of lipase production by Aspergillus ibericus from oil cakes and its application in esterification reactions

A novel conversion of sesamolin to sesaminol by acidic cation exchange resin

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