Increased Prevalence of Thyroid Disease in Patients with Antineutrophil Cytoplasmic Antibodies–associated Vasculitis

Prendecki, Maria; Martín, Leyre Lloreda; Tanna, Anisha; Antonelou, Marilina; Pusey, Charles D.

doi:10.3899/jrheum.170661

Cited by 12 publications

(13 citation statements)

References 18 publications

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“…Twenty-seven of 186 patients (14.5%) exhibited thyroid dysfunction, and 7 of them had overt thyroid dysfunction before diagnosis of AAV (Supplementary Table 1, available from the authors on request). The overall prevalence was lower than in previous studies (20.0-21.5%), but similar to that of another previous study (14.5%) 5,6,7 . Based on the report on thyroid dysfunction in the Korean general population 10 , patients with AAV exhibited the significantly increased prevalences of overt hyperthyroidism and hypothyroidism compared to the general population (5.4% vs 0.5% and 4.3% vs 0.7%, respectively).…”

supporting

confidence: 88%

“…Given that AAV is one of the systemic autoimmune diseases affecting most major organs 3 , and there is cross-reactivity between thyroid peroxidase and myeloperoxidase (MPO) molecules 4 , the prevalence of thyroid dysfunction, including autoimmune thyroiditis, may be increased in patients with AAV. Previous studies reported the higher prevalence of thyroid dysfunction in patients with AAV than in the general population 5,6,7 . However, there was no study on the prevalence of thyroid dysfunction in AAV patients in Korea.…”

mentioning

confidence: 81%

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Thyroid Dysfunction in Patients with Antineutrophil Cytoplasmic Antibody–associated Vasculitis: A Monocentric Retrospective Study

2019

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supporting

confidence: 88%

mentioning

confidence: 81%

Thyroid Dysfunction in Patients with Antineutrophil Cytoplasmic Antibody–associated Vasculitis: A Monocentric Retrospective Study

2019

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“…For example, AAV patients are commonly tested for hypothyroidism as part of their diagnostic evaluation. Nevertheless, an increased risk of hypothyroidism has previously been demonstrated in AAV patients prior to diagnosis, which aligns with accumulating evidence supporting shared mechanisms across the autoimmune disease spectrum (41). Similarly, the increased risk of osteoporosis in AAV patients observed in the present study may be related to current guideline recommendations for dual energy x-ray absorptiometry scans when patients commence treatment with glucocorticoids (30).…”

Section: Discussionsupporting

confidence: 88%

Multimorbidity in Antineutrophil Cytoplasmic Antibody–Associated Vasculitis: Results From a Longitudinal, Multicenter Data Linkage Study

Sarica

Gallacher

Dhaun

et al. 2021

Arthritis & Rheumatology

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Objective. Antineutrophil cytoplasmic antibody-associated vasculitis (AAV) is considered a chronic, relapsing condition. To date, no studies have investigated multimorbidity in AAV nationally. This study was undertaken to characterize temporal trends in multimorbidity and report excess health care expenditures associated with multimorbidities in a national AAV cohort from Scotland. Methods. Eligible patients with AAV were diagnosed between 1997 and 2017. Each patient was matched with up to 5 general population controls. Linked morbidity and health care expenditure data were retrieved from a Scottish national hospitalization repository and from published national cost data. Multimorbidity was defined as the development of ≥2 disorders. Prespecified morbidities, individually and together, were analyzed for risks and associations over time using modified Poisson regression, discrete interval analysis, and chi-square test for trend. The relationship between multimorbidities and health care expenditure was investigated using multivariate linear regression. Results. In total, 543 patients with AAV (median age 58.7 years [range 48.9-68.0 years]; 53.6% male) and 2,672 general population controls (median age 58.7 years [range 48.9-68.0 years]; 53.7% male) were matched and followed up for a median of 5.1 years. AAV patients were more likely to develop individual morbidities at all time points, but especially <2 years after diagnosis. The highest proportional risk observed was for osteoporosis (adjusted incidence rate ratio 8.0, 95% confidence interval [95% CI] 4.5-14.2). After 1 year, 23.0% of AAV patients and 9.3% of controls had developed multimorbidity (P < 0.0001). After 10 years, 37.0% of AAV patients and 17.3% of controls were reported to have multimorbidity (P < 0.0001). Multimorbidity was associated with disproportionate increases in health care expenditures in AAV patients. Health care expenditure was highest for AAV patients with ≥3 morbidities (3.89-fold increase in costs, 95% CI 2.83-5.31; P < 0.001 versus no morbidities). Conclusion. These findings emphasize the importance of holistic care in patients with AAV, and may identify a potentially critical opportunity to consider early screening.

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“…Whereas, In a study by Prendecki, of 275 patients with vasculitis, thyroid disorder was seen in 21.5% of the patiens. 16 Another study by Englund et al, showed thyroid disorder in 14.5% of the 186 patients with vasculitis. 17 Our study showed 42.9% of patients with mixed connective tissue disorder had thyroid dysfunction which was similar to a study by Biro et al in which 24% of the patients with mixed connective tissue disorder had thyroid dysfunction.…”

Section: Discussionmentioning

confidence: 97%

The prevalence of thyroid dysfunction in patients with connective tissue disorders

et al. 2021

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Background: Abnormalities in thyroid function have been reported in patients with connective tissue disorders. In India many patients suffer from thyroid dysfunction and rheumatological disorders. There is a lack of awareness of thyroid dysfunction in patients suffering from connective tissue disorders. Also, studies regarding the same are lacking in India. Aims and Objective: The current study was undertaken to estimate the Prevalence of Thyroid dysfunction in connective tissue disorders. Materials and Methods: It’s a duration based, prospective cross-sectional study including 100 patients. Patients presenting with connective tissue disorders were evaluated for thyroid function clinically and were subjected to serum TSH, Free T3, Free T4 and Anti-thyroid antibodies. The association was analyzed using frequency analysis, percentage analysis, and Chi-Square test. Results: Of the 100 patients in this study, predilection of connective tissue disorders was seen among females. The overall prevalence of thyroid dysfunction in patients with connective tissue disorder was 41%. 22% of the 100 patients had Anti-TPO antibodies suggestive of autoimmune thyroiditis. Our study showed 42.1% of the patients with rheumatoid arthritis, 45.5% of the patients with Systemic Lupus Erythematosus, 50% of the patients with Sjogren’s syndrome, 27.3% of the patients with Systemic sclerosis, and 42.9% of the patients with mixed connective tissue disorder had thyroid dysfunction. Conclusion: Our study demonstrates the increased prevalence of thyroid dysfunction among patients with connective tissue disorders and shows a female preponderance, in the age group of 45-65 years. Hence, early screening and intervention will prevent significant morbidity and improve the quality of patients’ life.

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Increased Prevalence of Thyroid Disease in Patients with Antineutrophil Cytoplasmic Antibodies–associated Vasculitis

Abstract: Our data show a higher prevalence of thyroid disease in patients with AAV than the general population. This was not attributable to antithyroid drugs.

Cited by 12 publications

References 18 publications

Thyroid Dysfunction in Patients with Antineutrophil Cytoplasmic Antibody–associated Vasculitis: A Monocentric Retrospective Study

Thyroid Dysfunction in Patients with Antineutrophil Cytoplasmic Antibody–associated Vasculitis: A Monocentric Retrospective Study

Multimorbidity in Antineutrophil Cytoplasmic Antibody–Associated Vasculitis: Results From a Longitudinal, Multicenter Data Linkage Study

The prevalence of thyroid dysfunction in patients with connective tissue disorders

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