2018
DOI: 10.3899/jrheum.170661
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Increased Prevalence of Thyroid Disease in Patients with Antineutrophil Cytoplasmic Antibodies–associated Vasculitis

Abstract: Our data show a higher prevalence of thyroid disease in patients with AAV than the general population. This was not attributable to antithyroid drugs.

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Cited by 11 publications
(5 citation statements)
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References 18 publications
(11 reference statements)
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“…For example, AAV patients are commonly tested for hypothyroidism as part of their diagnostic evaluation. Nevertheless, an increased risk of hypothyroidism has previously been demonstrated in AAV patients prior to diagnosis, which aligns with accumulating evidence supporting shared mechanisms across the autoimmune disease spectrum (41). Similarly, the increased risk of osteoporosis in AAV patients observed in the present study may be related to current guideline recommendations for dual energy x-ray absorptiometry scans when patients commence treatment with glucocorticoids (30).…”
Section: Discussionsupporting
confidence: 88%
“…For example, AAV patients are commonly tested for hypothyroidism as part of their diagnostic evaluation. Nevertheless, an increased risk of hypothyroidism has previously been demonstrated in AAV patients prior to diagnosis, which aligns with accumulating evidence supporting shared mechanisms across the autoimmune disease spectrum (41). Similarly, the increased risk of osteoporosis in AAV patients observed in the present study may be related to current guideline recommendations for dual energy x-ray absorptiometry scans when patients commence treatment with glucocorticoids (30).…”
Section: Discussionsupporting
confidence: 88%
“…Twenty-seven of 186 patients (14.5%) exhibited thyroid dysfunction, and 7 of them had overt thyroid dysfunction before diagnosis of AAV (Supplementary Table 1, available from the authors on request). The overall prevalence was lower than in previous studies (20.0-21.5%), but similar to that of another previous study (14.5%) 5,6,7 . Based on the report on thyroid dysfunction in the Korean general population 10 , patients with AAV exhibited the significantly increased prevalences of overt hyperthyroidism and hypothyroidism compared to the general population (5.4% vs 0.5% and 4.3% vs 0.7%, respectively).…”
supporting
confidence: 88%
“…Given that AAV is one of the systemic autoimmune diseases affecting most major organs 3 , and there is cross-reactivity between thyroid peroxidase and myeloperoxidase (MPO) molecules 4 , the prevalence of thyroid dysfunction, including autoimmune thyroiditis, may be increased in patients with AAV. Previous studies reported the higher prevalence of thyroid dysfunction in patients with AAV than in the general population 5,6,7 . However, there was no study on the prevalence of thyroid dysfunction in AAV patients in Korea.…”
mentioning
confidence: 81%
“…Whereas, In a study by Prendecki, of 275 patients with vasculitis, thyroid disorder was seen in 21.5% of the patiens. 16 Another study by Englund et al, showed thyroid disorder in 14.5% of the 186 patients with vasculitis. 17 Our study showed 42.9% of patients with mixed connective tissue disorder had thyroid dysfunction which was similar to a study by Biro et al in which 24% of the patients with mixed connective tissue disorder had thyroid dysfunction.…”
Section: Discussionmentioning
confidence: 97%