Increased prevalence of interstitial cystitis: previously unrecognized urologic and gynecologic cases identified using a new symptom questionnaire and intravesical potassium sensitivity

Parsons, C. Lowell; Dell, Jeffrey R.; Stanford, Edward J.; Bullen, Michael; Kahn, Bruce S.; Waxell, Tracy; Koziol, James A.

doi:10.1016/s0090-4295(02)01829-0

Cited by 329 publications

(212 citation statements)

References 19 publications

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“…Baseline voiding diaries were obtained, including urinary frequency, voided volumes and incontinent episodes. In addition the O'Leary/Sant IC Symptom Problem Index (ICSPI) [7] and Pain Urgency and Frequency (PUF) questionnaires [8] were completed. All procedures were performed by one surgeon (K.M.P.…”

Section: Methodsmentioning

confidence: 99%

A prospective, single‐blind, randomized crossover trial of sacral vs pudendal nerve stimulation for interstitial cystitis

2007

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generator and patients were followed at 1, 3 and 6 months. RESULTSThe time required to place a sacral lead was 27.4 min, and a pudendal lead 19.6 min ( P = 0.039). Of the 22 patients, 17 (77%) responded and had a permanent implant placed. PNS was chosen as the better lead in 77% and SNS in 24%. The order in which the lead was stimulated had no effect on the final lead implanted and there was no 'carry-over' effect. The overall reduction in symptoms was 59% for PNS and 44% for SNS ( P = 0.05). At 6 months after implantation, voids improved by 41% (PNS) and 33% (SNS), and mean voided volume increased 95% and 21%, respectively; validated IC questionnaires improved markedly and complications were minimal. CONCLUSIONSThis is the first 'blinded' study of SNS vs PNS for IC. A pudendal lead was implanted successfully in all patients, and most chose PNS as better than SNS; the improvement was sustained over time.

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Section: Methodsmentioning

confidence: 99%

A prospective, single‐blind, randomized crossover trial of sacral vs pudendal nerve stimulation for interstitial cystitis

2007

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“…9,10 Previously, several trials were reported of L-arginine and quercetin that have similar anti-oxidant mechanism. [9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25] L-arginine supplementation is used to counteract reduced production of nitric oxide (NO). NO is the oxidation product of L-arginine, a reaction catalyzed by NO synthase (NOS).…”

Section: Discussionmentioning

confidence: 99%

“…These patients were assessed using the O'Leary-Sant validated Interstitial Cystitis Symptom Index (ICSI) and Problem Index (ICPI), 12 the Pelvic Pain and Urgency/Frequency (PUF) Patient Symptom Scale, 13 The participants were instructed not to change comestibles or lifestyle during this study period.…”

Section: Study Protocolmentioning

confidence: 99%

Effect of Supplementation With Hydrogen-rich Water in Patients With Interstitial Cystitis/Painful Bladder Syndrome

Matsumoto

Ueda

Κakizaki

2013

Urology

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Results: A total of 30 participants (29 female, 1 male, age 64.0 ± 14.8 years) were enrolled into the study and two cases (all females) were withdrawn from the study.The score of bladder pain was significantly reduced in both groups. However, the effect of hydrogen-rich water on symptoms was not significantly different from placebo, although the supplementation with hydrogen-rich water was extremely effective in improving bladder pain score in 11 % of the patients. Conclusions:The results of the present study do not support the use of supplementation with hydrogen-rich water for treating patients with IC/PBS.3

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“…To determine treatment efficacy, patient symptoms were recorded and a voiding diary and the visual analogue scale (VAS) were used along with two published IC symptom questionnaires: the O'Leary-Sant IC symptom index and the IC problem index [13] and the pelvic pain and urgency/frequency (PUF) scale [14]. The questionnaire scores before and after HU fulguration were then compared.…”

Section: Introductionmentioning

confidence: 99%

468 Elimination of Hunner's ulcers by fulguration in patients with interstitial cystitis: Is it effective and long lasting?

Song¹,

Chun²,

Park³

et al. 2014

European Urology Supplements

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Purpose:To evaluate the outcome of fulguration of Hunner's ulcers (HUs) in painful bladder syndrome/interstitial cystitis (PBS/IC) that is refractory to conservative treatment. Materials and Methods: Patients diagnosed with refractory PBS/IC and treated with fulguration between 2011 and 2013 were identified through screening of medical records. To evaluate treatment outcomes, voiding diaries, the visual analogue scale (VAS) for pain, and two IC symptom questionnaires (pelvic pain and urgency/frequency scale [PUF] and O'Leary-Sant IC symptom index and IC problem index [OS]) were used. Fulguration was deemed to be successful if the VAS score was ＜2 or less than half of the preoperative VAS score. Results: In total, 27 patients with PBS/IC in whom conservative treatments had failed were enrolled. Two months after fulguration, decreases were observed in the mean 24-hour urinary frequency (from 16.0 to 10.2), 24-hour urgency episodes (8.0 to 1.8), and the VAS (5.8 to 1.2), PUF symptom (15.1 to 7.0), PUF bother (8.4 to 2.7), OS symptom (15.1 to 7.2), and OS problem (13.8 to 6.0) scores. At 5 and 10 months, all variables had worsened. At 2, 5, and 10 months, the success rates were 94.1%, 70.0%, and 33.3%, respectively. Four patients underwent one repeat fulguration on average 11.3 months after the first fulguration. Repeat fulguration was not significantly associated with any clinical characteristics. Conclusions: In PBS/IC that was refractory to medication or other conservative treatments, HU elimination by fulguration effectively improved symptoms. However, this effect decreased gradually over time.

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Increased prevalence of interstitial cystitis: previously unrecognized urologic and gynecologic cases identified using a new symptom questionnaire and intravesical potassium sensitivity

Cited by 329 publications

References 19 publications

A prospective, single‐blind, randomized crossover trial of sacral vs pudendal nerve stimulation for interstitial cystitis

A prospective, single‐blind, randomized crossover trial of sacral vs pudendal nerve stimulation for interstitial cystitis

Effect of Supplementation With Hydrogen-rich Water in Patients With Interstitial Cystitis/Painful Bladder Syndrome

468 Elimination of Hunner's ulcers by fulguration in patients with interstitial cystitis: Is it effective and long lasting?

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