A prospective, single‐blind, randomized crossover trial of sacral vs pudendal nerve stimulation for interstitial cystitis

Peters, Kenneth M.; Feber, Kevin; Bennett, R. C.

doi:10.1111/j.1464-410x.2007.07082.x

Cited by 141 publications

(102 citation statements)

References 14 publications

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“…Novel concepts for the treatment of CPPS are percutaneous tibial nerve stimulation, electroacupuncture, high-frequency sacral magnetic stimulation, sacral neuro-modulation (SNM), and pudendal neuromodulation [33]. Yet another type of neuromodulation is TENS, which has been established for the treatment of chronic musculoskeletal pain and may also be a valuable option in pelvic pain [34].…”

Section: Discussionmentioning

confidence: 99%

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Cycling Sacral Root Neuromodulation: Pilot Study to Assess the Effectiveness of This Mode in Neuromodulator Programming for the Treatment of Chronic Pelvic Pain Syndrome

Cappellano¹,

Ciotti²,

Tafuri³

et al. 2017

Med Surg Urol

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Aim: There is lack of evidence of the role of sacral root neuromodulation (SNM) in the management of chronic pelvic pain syndrome (CPPS). We evaluated the effectiveness of cycling sacral root neuromodulation (CSNM) in the management of CPPS in patients non responders to conservative treatment. Methods:A prospective, single center, cohort study was carried out on all patients with CPPS refractory to conventional treatment, who underwent test stimulation using the tined lead between February 2012 and March 2016. During test stimulation the tine lead was positioned along the third sacral nerve, on the side where they reported more pain. Success was defined as >50% improvement of pain and concurrent urinary symptoms. After a successful SNM test period of 4 weeks, patients received a permanent implant. We also included 9 more patients already with a permanent implant and partial responders to continuous mode in neuromodulator programming. To assess pain and quality of life, all patients filled-in a VAS scale and SF-36 and McGill questionnaires, at baseline, after the 4-week test period ad after the permanent implant.Results: Overall 22 consecutive adult patients were suitable to undergo a cycling test stimulation; 19 out of them (86.3%) underwent a permanent implant after a satisfactory test phase, using a codified cycling mode of programming. Eighteen naive patients out of nineteen (94.7%) maintained the benefits of the test stimulation at a mean follow up of 21.3 months. VAS scale, McGill and SF-36 questionnaires scores improved significantly in all domains with a 95% satisfaction rate; 7 out of the 9 already implanted patients (77.7%) significantly improved their pain control.Conclusion: CSRN appears to be effectiveness in treating CPPS in both naïve and previous implanted partial responder patients.

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Section: Discussionmentioning

confidence: 99%

“…The second aim was trying to further detect if CSRN can improve the outcome in CPPS patients with partial response to "conventional" SNM, as several articles in the treatment of CPP [9][10][11][12] reported an overall mean success rate of 60%.…”

Section: Introductionmentioning

confidence: 99%

Cycling Sacral Root Neuromodulation: Pilot Study to Assess the Effectiveness of This Mode in Neuromodulator Programming for the Treatment of Chronic Pelvic Pain Syndrome

Cappellano¹,

Ciotti²,

Tafuri³

et al. 2017

Med Surg Urol

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“…kann nach erfolgloser SNM erwogen werden [43]. Peters et al [42,43] Im Vergleich zur Gruppe, die nur eine Instruktion erhielt (keine weitere Therapie).…”

Section: Pudendale Nervenstimulationunclassified

“…kann nach erfolgloser SNM erwogen werden [43]. Peters et al [42,43] Im Vergleich zur Gruppe, die nur eine Instruktion erhielt (keine weitere Therapie). PS prospektive Studie, RCT prospektive randomisierte und kontrollierte Studie ("randomized controlled trial"), NIH-CPSI "National Institutes of Health Chronic Prostatitis Symptom Index", n.s.…”

Section: Pudendale Nervenstimulationunclassified

Chronisches Schmerzsyndrom des Beckens

Walter

Sammer

Kessler

2012

Urologe

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Chronic pelvic pain syndrome (CPPS) is defined by the European Association of Urology guidelines as a non-malignant pain perceived in structures related to the pelvis of either women or men for at least 6 months without proven infection or other obvious pathology. It affects the quality of life of millions of people worldwide and has an impact similar to that reported for other chronic diseases, such as diabetes mellitus, Crohn's disease and congestive heart failure. The treatment of CPPS remains a challenge despite several established first line therapies because many patients are therapy refractory. Unconventional treatments, such as neurostimulation, neuromodulation and acupuncture may be highly successful for treating CPPS and have a favorable adverse event profile. Thus, these promising therapeutic alternatives should be considered more often in daily clinical practice. DOI: https://doi.org/10.1007/s00120-012-3037-9Other titles: Chronic pelvic pain syndrome: neurostimulation, neuromodulation and acupuncture "chronic pelvic pain syndrome", "neurostimulation", "neuromodulation", "acupuncture") und schlossen nur Originaloder Übersichtsarbeiten in deutscher oder englischer Sprache ein. Transkranielle Stimulation durch Strom oder MagnetfeldDie transkranielle Stimulation durch Strom ("transcranial direct current stimulation", tDCS) zur Behandlung des CPPS wurde bisher nur in einer Studie untersucht. Im Rahmen einer prospektiven, randomisierten, doppelt verblindeten Crossover-Studie wurden 7 therapierefraktäre CPPS-Patienten mit einem Durchschnittsalter von 38 Jahren eingeschlossen [19]. Die aktive Therapie wurde über einen Zeitraum von 2 Tagen für jeweils 20 min mittels direkter Stromapplikation von 1 mA durchgeführt. In der Sham-Gruppe wurde die Stimulation bereits nach 30 s wieder beendet. In der aktiven Therapiegruppe zeigte sich im Vergleich zur Sham-Gruppe auf einer visuellen Analogskala (VAS) eine signifikante Reduktion der Becken-und Gesamtschmerzsymptomatik. Nebenwirkungen wie Kopf-und Nackenschmerzen, Brennen und Schmerzen der Kopfhaut traten in beiden Gruppen gleichhäufig auf. Es kam zu keinem nebenwirkungsbedingten Studienabbruch.

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“…[55] reported that only one of four patients with interstitial cystitis was improved after a mean follow-up of 6.5 years. A randomized crossover trial of sacral vs pudendal nerve stimulation (with the InterStim system) for interstitial cystitis indicated that overall symptom reduction with pudendal nerve stimulation might be somewhat better than with SNM (59% vs 44%; P = 0.05) [81]. Of those with a permanent IPG 13 of 17 chose the pudendal lead.…”

Section: Interstitial Cystitismentioning

confidence: 99%

An update on sacral neuromodulation: where do we stand with this in the management of lower urinary tract dysfunction in 2010?

Bosch

2010

BJU International

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A prospective, single‐blind, randomized crossover trial of sacral vs pudendal nerve stimulation for interstitial cystitis

Cited by 141 publications

References 14 publications

Cycling Sacral Root Neuromodulation: Pilot Study to Assess the Effectiveness of This Mode in Neuromodulator Programming for the Treatment of Chronic Pelvic Pain Syndrome

Cycling Sacral Root Neuromodulation: Pilot Study to Assess the Effectiveness of This Mode in Neuromodulator Programming for the Treatment of Chronic Pelvic Pain Syndrome

Chronisches Schmerzsyndrom des Beckens

An update on sacral neuromodulation: where do we stand with this in the management of lower urinary tract dysfunction in 2010?

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