Effect of Supplementation With Hydrogen-rich Water in Patients With Interstitial Cystitis/Painful Bladder Syndrome

Abstract

<UROLOGY>Results: A total of 30 participants (29 female, 1 male, age 64.0 ± 14.8 years) were enrolled into the study and two cases (all females) were withdrawn from the study.The score of bladder pain was significantly reduced in both groups. However, the effect of hydrogen-rich water on symptoms was not significantly different from placebo, although the supplementation with hydrogen-rich water was extremely effective in improving bladder pain score in 11 % of the patients. Conclusions:The results of the present study do not support the use of supplementation with hydrogen-rich water for treating patients with IC/PBS.3

Hydrogen-rich water attenuates amyloid β-induced cytotoxicity through upregulation of Sirt1-FoxO3a by stimulation of AMP-activated protein kinase in SK-N-MC cells

“…A C C E P T E D ACCEPTED MANUSCRIPT 18 with recent studies that molecular hydrogen protects against neuronal apoptosis by improving mitochondrial dysfunction by suppressing ROS-activated caspase signaling [38]. The FoxO3a protein is also thought to be involved in mitochondrial protection by increasing a wide range of mitochondrial antioxidant enzymes [39].…”

“…Moreover, some studies reported HRW can significantly reduce several neurodegenerative diseases and this is associated with increased defense to oxidative stress [16]. Recently, clinical trials have also proven the benefits of HRW in attenuating oxidative stress and inflammation in patients [17,18]. Particularly, oral intake of HRW displays anti-neurotoxicity effects by regulating the oxidant and antioxidant status of rats [19].…”

Molecular Hydrogen in Sports Medicine: New Therapeutic Perspectives

“…Pronounced effects in human studies are observed especially in oxidative stress-mediated diseases, including cerebral infarction [45], liver carcinoma [26], chronic inflammation in hemodialysis patients [38], inflammatory and mitochondrial myopathies [22], metabolic syndrome [36], diabetes mellitus [24], Parkinson's disease [61] and rheumatoid arthritis [21]. One study reported no beneficial effects of H 2 in urology patients [32]. The summary of the human studies is presented in • ▶ Table 1.…”

“…To provide evidence of the safety of H 2 application in humans, several studies assessed the possible side effects of hydrogenrich water on clinical chemistry parameters and subjectively reported adverse events of intervention. The majority of the studies revealed no side effects of hydrogen-rich water administration in humans [21,26,32,46,48,49,61]. Nakao et al [36] found minimal disturbances in liver enzymes and biochemical profiles in subjects with potential metabolic syndrome receiving up to 2 L/day of hydrogen-rich water.…”

Clinical Effects of Hydrogen Administration: From Animal and Human Diseases to Exercise Medicine

“…They were treated with H 2 -enriched water or placebo for 8 weeks. Although hydrogen intake did not change significantly the IC/PBS clinical scores during the study, there were improvements in pain perception in 11% of the patients [294].…”