Increased oxidative stress in childhood atopic dermatitis

Omata, Nemuko; Tsukahara, Hirokazu; Ito, Setsuko; Ohshima, Yusei; Yasutomi, Motoko; Yamada, Akiko; Jiang, Mizu; Hiraoka, Masahiro; Nambu, Mitsuhiko; Deguchi, Yoshizumi; Mayumi, Mitsufumi

doi:10.1016/s0024-3205(01)01124-9

Cited by 140 publications

(122 citation statements)

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“…Urine concentrations of 8-hydroxy-29-deoxyguanosine (8-OHdG, a marker of oxidative DNA damage) are significantly higher in children with AD compared with healthy controls (8). Also, urinary acrolein-lysine adducts (markers of lipid peroxidation) are significantly higher in children with AD (32).…”

Section: Discussionmentioning

confidence: 99%

“…In skin inflammation associated with AD, ROS are released during the activation and infiltration of lymphocytes, monocytes, and eosinophils (5-7). In addition, markers of oxidative stress have been shown to be increased in children with AD (8), implicating ROS and their products in the pathology of AD. Thus, it is possible that genetic factors that affect the capacity of cells to detoxify ROS and their products are important determinants in the development of AD.…”

Section: Introductionmentioning

confidence: 99%

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Association of glutathione-S-transferase polymorphisms with atopic dermatitis risk in preschool age children

Chung

Shin

2009

Clinical Chemistry and Laboratory Medicine

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Background: Glutathione S-transferase (GST) enzymes are critical for detoxifying reactive oxygen species (ROS) and their products which have been implicated in the pathology of inflammatory diseases such as atopic dermatitis (AD). Methods:We investigated the effects of genetic polymorphisms of GST on the risk of AD in preschool age children. Biomarkers for oxidative stress were also evaluated with respect to GST genotype. Results: The GSTP1 Val105 allele was significantly associated with an increased risk of AD wodds ratio (OR)s1.62, p-0.05x. The combination of the GSTP1 Val105 allele and the GSTT1 null genotype further increased this risk by 2.3-fold (p-0.01). No association was observed for the GSTM1 null or GSTT1 null genotype alone. In children with AD, blood total antioxidant capacity was significantly less (p-0.001), while malondialdehyde was higher (ps0.12). Children with the GSTP1 Val105 allele had significantly lower concentrations of erythrocyte glutathione compared to GSTP1 Ile/Ile homozygotes (ps0.03). Conclusions: Our study suggests that the GSTP1 Val105 allele is an important determinant of susceptibility to AD in preschool age children and increased oxidative stress may play a role in the pathogenesis of AD.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association of glutathione-S-transferase polymorphisms with atopic dermatitis risk in preschool age children

Chung

Shin

2009

Clinical Chemistry and Laboratory Medicine

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“…Genetic factors, impairment of the skin barrier followed by antigen trespassing, immune system deviation and microbial superinfections are proven to be involved in the pathogenesis of CAD Marsella et al 2011). In the last decade, oxidative stress (OS) has been well documented to play an important role in the pathogenesis of human AD (Tsuboi et al 1998;Omata et al 2001;Antille et al 2002;Niwa et al 2003;Nakai et al 2009). Hydrogen peroxide, a potent reactive oxygen species (ROS), is indispensable for T-cell activation upon triggering of the T-cell receptor by antigen presenting cells (Kami nski et al 2010).…”

Section: Introductionmentioning

confidence: 99%

Plasma and skin vitamin E concentrations in canine atopic dermatitis

Kapun¹,

Salobir

Levart

et al. 2013

Veterinary Quarterly

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Background: Altered homeostasis of vitamin E has been demonstrated in human atopic dermatitis. Data on plasma and skin vitamin E concentrations in canine atopic dermatitis (CAD) are not available. Objective: To determine vitamin E concentrations in plasma and skin of atopic dogs. Animals and Methods: Vitamin E concentrations in plasma and full-thickness skin biopsies of 15 atopic dogs were related to CAD extent and severity index (CADESI-03) scores and compared to the equivalent concentrations in 17 healthy dogs. Statistically significant differences of measured parameters between the two groups were determined by the nonparametric Mann Whitney U test and correlations between CADESI-03 scores and vitamin E concentrations were evaluated by the Spearman rank test. A value of P < 0.05 was considered significant. Results: Plasma concentrations of vitamin E were significantly lower in atopic dogs than in healthy dogs, with median values of 29.8 and 52.9 mmol/L, respectively. Skin vitamin E values did not differ significantly between patients and healthy controls. The median concentration of skin vitamin E in atopic dogs was higher than that in healthy dogs. No significant correlations were found between CADESI-03 score and plasma vitamin E or skin vitamin E concentrations. Conclusions: Significantly lower plasma vitamin E concentrations in atopic dogs than in healthy controls indicate altered homeostasis of vitamin E in CAD. Clinical importance: Further investigation into vitamin E supplementation in CAD is warranted.

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“…Firstly, the inflammatory process results in the generation of oxygen free radicals, and antioxidant defence systems are important in controlling inflammation (Greene, 1999). Atopic diseases, in particular asthma and atopic dermatitis, are characterized by increased oxidative stress (Montuschi et al, 1999;Omata et al, 2001). Second, there is evidence that a low antioxidant intake may be associated with allergic symptoms; low vitamin C intake has been linked with wheezing (Bodner et al, 1999) and bronchial hyper-reactivity (Soutar et al, 1997) and an inverse association has been observed between dietary vitamin E intake and serum total IgE .…”

Section: Introductionmentioning

confidence: 99%

Vitamin C in breast milk may reduce the risk of atopy in the infant

et al. 2004

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Objective: To assess the effects of maternal dietary and supplement intake of vitamins C and E on breast milk antioxidant composition (vitamin C, a-tocopherol and b-carotene) and their protective potential against the development of atopy in the infant. Design, subjects and methods: Mothers with atopic disease were recruited at the end of gestation and maternal sensitization was assessed by skin-prick testing. The 4-day food records of the mothers and breast milk samples were collected at the infants' age of 1 month. Infants' atopy was defined by the presence of atopic dermatitis during the first year of life and a positive skinprick test reaction at 12 months of age (n ¼ 34). Results: Maternal intake of vitamin C in diet but not as supplement was shown to determine the concentration of vitamin C in breast milk. A higher concentration of vitamin C in breast milk was associated with a reduced risk of atopy in the infant (OR ¼ 0.30; 95% CI 0.09-0.94; P ¼ 0.038), whereas a-tocopherol had no consistent relationship with atopy. The group at risk of suboptimal vitamin C supply from breast milk was identified as infants whose mothers suffer from food hypersensitivity. Conclusion: A maternal diet rich in natural sources of vitamin C during breastfeeding could reduce the risk of atopy in high-risk infants. Sponsorship: The Academy of Finland, the Juho Vainio Foundation and the Finnish Cultural Foundation.

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Increased oxidative stress in childhood atopic dermatitis

Cited by 140 publications

References 0 publications

Association of glutathione-S-transferase polymorphisms with atopic dermatitis risk in preschool age children

Association of glutathione-S-transferase polymorphisms with atopic dermatitis risk in preschool age children

Plasma and skin vitamin E concentrations in canine atopic dermatitis

Vitamin C in breast milk may reduce the risk of atopy in the infant

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