Plasma and skin vitamin E concentrations in canine atopic dermatitis

Kapun, A. Plevnik; Salobir, Janez; Levart, Alenka; Kalcher, Gabrijela Tavčar; Svete, Alenka Nemec; Kotnik, Tina

doi:10.1080/01652176.2012.758395

Cited by 9 publications

(8 citation statements)

References 33 publications

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“…Lack of vitamin E in people with different skin diseases has been shown to be associated with increased concentrations of reactive oxygen species (ROS), cell damage and consequent damage to various tissues, leading to a variety of disorders (Jain and others 1988, Passi and others 1991, Kökçem and Naziroğlu 1999, Briganti and Picardo 2003, Sivaranjani and others 2013). Significantly lower plasma levels of vitamin E in atopic dogs than in healthy dogs were demonstrated in the previous study (Plevnik Kapun and others 2013). Adding vitamin E to the therapy of human AD has been proved to lower serum IgE levels and hasten remission of clinical symptoms (Tsoureli Nikita and others 2002).…”

Section: Introductionsupporting

confidence: 53%

Vitamin E supplementation in canine atopic dermatitis: improvement of clinical signs and effects on oxidative stress markers

Kapun¹,

Salobir

Levart

et al. 2014

Veterinary Record

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Low levels of plasma vitamin E concentrations were found in canine atopic dermatitis (CAD). The present study was aimed at determining the effect of an eight-week vitamin E supplementation on clinical response (Canine Atopic Dermatitis Extent and Severity Index (CADESI-03) scores and pruritus intensity) in dogs with atopic dermatitis. Levels of oxidative stress markers (plasma malondialdehyde and total antioxidant capacity (TAC), blood glutathione peroxidase and erythrocyte superoxide dismutase, plasma and skin vitamin E concentrations) were also determined. Twenty-nine dogs with CAD were included in the study. Fourteen received vitamin E (8.1 IU/kg once daily, orally) and 15 received mineral oil as placebo (orally). All dogs were treated with antihistamine fexofenadine. Levels of oxidative stress markers (with the exception of skin vitamin E), CADESI-03 and pruritus intensity were determined at the beginning, then every two weeks. Skin vitamin E was determined at the beginning and at the end of the treatment. Significantly higher plasma levels of vitamin E and TAC were observed in the vitamin E group than in the placebo group. CADESI-03 scores determined throughout the treatment in the vitamin E group were significantly lower than in the placebo group. The findings of this study support the supplementation of vitamin E in dogs with atopic dermatitis.

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Section: Introductionsupporting

confidence: 53%

Vitamin E supplementation in canine atopic dermatitis: improvement of clinical signs and effects on oxidative stress markers

Kapun¹,

Salobir

Levart

et al. 2014

Veterinary Record

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“…Vitamins D supplementation has shown to be beneficial in case of AD [95] while vitamin E acts as an antioxidant improving the clinical status of dogs with moderate AD [96][97][98], reducing the biosynthesis of prostaglandin E2 [99], inhibiting formation of IgE and decreasing its amount [100,101].…”

Section: Vitamins and Mineralsmentioning

confidence: 99%

Impact of Nutritional Supplementation on Canine Dermatological Disorders

Marchegiani

Fruganti

Spaterna

et al. 2020

Veterinary Sciences

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Nutritional supplements, also known as complementary feeds, are products administered with the aim of furnishing health benefits, regardless of nutritional needs. They have been used since ancient times in veterinary dermatology, and a number of studies have focused on investigating the health benefits of some ingredients found in commercially available complementary feed for dogs. The aim of this paper is to review the literature available on the use of nutritional supplementation for the management of canine skin diseases, critically appraising the clinical efficacy of such interventions and summarizing the current state of knowledge. This review highlights how these feeds can be considered useful in the management of dermatological disorders and outlines their beneficial effects in the prevention of dietary deficiencies and treatment of diseases, alone, or in addition to conventional pharmacological therapy. In recent years, nutritional supplements have found increasing potential application in veterinary medicine, and the scientific proofs of their beneficial effects are described in this review.

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“…The author of the present article believes that vitamin E supplemented at higher dosages could improve the outcome of CAD. Plevnik Kapun et al (2013; proved the beneficial influence of vitamin E supplementation in CAD. Plasma vitamin E concentrations in dogs with moderate atopic dermatitis were shown to be significantly lower than in healthy controls and significantly lower scores of CADESI-03 were found in atopic dogs treated with vitamin E compared to atopic dogs in a placebo group (Plevnik Kapun et al, 2013;.…”

Section: Discussionmentioning

confidence: 98%

Hypersensitivity in a dog accompanied by generalised onychodystrophy

Kotnik

2018

VET GLASNIK

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Canine food hypersensitivity and canine atopic dermatitis are two of the most common allergic diseases in dogs. Food hypersensitivity is typically non-seasonal reaction of types I, III and IV, directed most commonly against glycoproteins in the foods. Canine atopic dermatitis is a genetically predisposed inflammatory and pruritic allergic skin disease with characteristic clinical features associated with IgE most commonly directed against environmental allergens. Irrespective of allergens that dogs are sensitised to, clinical symptoms in acute cases involve pruritus with erythema of the skin around lips, axillae, inguinal and perianal region or feet as well as external ear canal inflammation. In chronic cases, consequences of self-trauma and secondary bacterial or fungal infections may be present as excoriations, lichenification and hyperpigmentation. Hypersensitivity can have a strong impact on quality of life of diseased dogs as well as of their owners.A mixed breed female dog with heavily expressed generalised onychodystrophy accompanied by mild erythema of the groin and external ear canals, which responded to elimination diet and allergen-specific immunotherapy, is presented.

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Plasma and skin vitamin E concentrations in canine atopic dermatitis

Cited by 9 publications

References 33 publications

Vitamin E supplementation in canine atopic dermatitis: improvement of clinical signs and effects on oxidative stress markers

Vitamin E supplementation in canine atopic dermatitis: improvement of clinical signs and effects on oxidative stress markers

Impact of Nutritional Supplementation on Canine Dermatological Disorders

Hypersensitivity in a dog accompanied by generalised onychodystrophy

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