Increased number of high sensitive platelets in hypercholesterolemia, cardiovascular diseases, and after incubation with cholesterol

Opper, C.; Clement, Cristina C.; Schwarz, Herman; Krappe, J.; Steinmetz, Armin; Schneider, Jürgen; Wesemann, W.

doi:10.1016/0021-9150(94)05448-r

Cited by 52 publications

(31 citation statements)

References 21 publications

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“…In closing, we report for the fi rst time that non-HDL-C is directly related to abundance measures of circulating erythrocytes and platelets in the US population, whereas HDL-C is directly related to MCV. Given that elevated erythrocytes, elevated platelets, and hypercholesterolemia are all established risk factors for coronary disease and that hypercholesterolemia impairs erythrocyte deformability ( 55 ) and activates platelets ( 56,57 ), our fi ndings suggest an important need for characterizing possible mechanisms by which serum cholesterol and the population kinetics of erythrocytes and platelets may impact one another. …”

Section: Discussionmentioning

confidence: 95%

Relationship between serum cholesterol and indices of erythrocytes and platelets in the US population

Fessler

Rose

Zhang

et al. 2013

Journal of Lipid Research

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Section: Discussionmentioning

confidence: 95%

Relationship between serum cholesterol and indices of erythrocytes and platelets in the US population

Fessler

Rose

Zhang

et al. 2013

Journal of Lipid Research

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“…30 This may represent an inhibition of the enhanced activation that occurs in hypercholesterolaemic subjects. 31,32 In support of this hypothesis is the lower excretion of urinary 11-dehydrothromboxane B 2 (an established marker of platelet activation), which also occurs following vitamin E supplementation. 30 A possible mechanism by which vitamin E prevents the elevation of soluble P-selectin post-PTCA is through its inhibitory action on protein kinase C (PKC).…”

Section: Effects Of Vitamin E Supplementation On Plasma Lipid and Vitmentioning

confidence: 98%

Effect of vitamin E supplementation on circulating cell adhesion molecules pre- and post-coronary angioplasty

Ferns¹,

Forster²,

Williams³

et al. 2000

Ann Clin Biochem

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SUMMARY.The soluble adhesion molecules P-selectin (sP-selectin) and intercellular adhesion molecule-1 (sICAM-1) are derived from platelets and endothelial cells. Circulating concentrations of these soluble adhesion molecules are raised in patients with atherosclerosis and following percutaneous transluminal coronary angioplasty (PTCA). We have investigated the effects of vitamin E supplements (800 IU/day) on circulating plasma ICAM-1 and P-selectin levels pre-and post-PTCA. Patients, randomized to group, were pre-treated with vitamin E or placebo (soybean oil) for 1 month before routine PTCA. Plasma sICAM-1 and sP-selectin were measured by enzyme-linked immunosorbent assay on blood taken immediately pre-and post-PTCA. Total protein and a-tocopherol were measured on the same samples. Plasma a-tocopherol concentrations increased in patients receiving vitamin E: 19´1 (1´5) [mean (standard error of the mean, SEM)] mg/mL post-PTCA versus 13´9 (0´6) mg/ mL pre-PTCA (n=23; P50´01). Plasma sP-selectin and sICAM-1 levels were not signi®cantly increased following PTCA in the vitamin E group. Pre-angioplasty mean (SEM) plasma sP-selectin concentration in the vitamin E group was 8´83 (0´97) ng/mg protein; the corresponding mean post-angioplasty value was 9´34 (0´89) ng/mg protein (P=0´85). The mean (SEM) pre-angioplasty sICAM-1 concentration in this group was 2´18 (0´24) ng/mg protein, and was 2´20 (0´23) ng/ mg protein following angioplasty (P=0´84). In the placebo group (n=24) there was a signi®cant increase in mean (SEM) sP-selectin concentration following angioplasty, from 7´48 (0´73) to 9´70 (0´78) ng/mg protein (P50´05). The change (mean, SEM) in plasma sP-selectin concentration following angioplasty was signi®cantly greater for the placebo group [2´22 (0´50) ng/mg protein] than for the group receiving vitamin E [0´50 (0´50) ng/mg protein] (P50´02). This difference remained signi®cant (P50´05) even after adjustment for pre-angioplasty P-selectin concentrations. Mean (SEM) plasma sICAM-1 concentrations remained unchanged following angioplasty [preangioplasty: 2´16 (0´20) ng/mg protein; post-angioplasty: 1´97 (0´13) ng/mg protein]. Vitamin E may therefore limit platelet or endothelial activation during PTCA.Vitamin E is a potent, lipid-soluble plasma antioxidant. Taking supplements of vitamin E has been shown to be associated with reduced risk of coronary heart disease in men and women.

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“…Circulating platelets are associated with mural thrombus formation at the site of plaque rupture and vascular injury (87,88). Hypercholesterolemia is associated with increases in platelet reactivity (89). These abnormalities are linked to increases in the cholesterol/phospholipid ratio in platelets.…”

Section: Statins and Platelet Functionmentioning

confidence: 99%

Pleiotropic Effects of Statins

Liao

Laufs

2005

Annu. Rev. Pharmacol. Toxicol.

1,595

1,198

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Statins are potent inhibitors of cholesterol biosynthesis. In clinical trials, statins are beneficial in the primary and secondary prevention of coronary heart disease. However, the overall benefits observed with statins appear to be greater than what might be expected from changes in lipid levels alone, suggesting effects beyond cholesterol lowering. Indeed, recent studies indicate that some of the cholesterol-independent or "pleiotropic" effects of statins involve improving endothelial function, enhancing the stability of atherosclerotic plaques, decreasing oxidative stress and inflammation, and inhibiting the thrombogenic response. Furthermore, statins have beneficial extrahepatic effects on the immune system, CNS, and bone. Many of these pleiotropic effects are mediated by inhibition of isoprenoids, which serve as lipid attachments for intracellular signaling molecules. In particular, inhibition of small GTP-binding proteins, Rho, Ras, and Rac, whose proper membrane localization and function are dependent on isoprenylation, may play an important role in mediating the pleiotropic effects of statins.

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Increased number of high sensitive platelets in hypercholesterolemia, cardiovascular diseases, and after incubation with cholesterol

Cited by 52 publications

References 21 publications

Relationship between serum cholesterol and indices of erythrocytes and platelets in the US population

Relationship between serum cholesterol and indices of erythrocytes and platelets in the US population

Effect of vitamin E supplementation on circulating cell adhesion molecules pre- and post-coronary angioplasty

Pleiotropic Effects of Statins

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