Increased monomeric CRP levels in acute myocardial infarction: A possible new and specific biomarker for diagnosis and severity assessment of disease

Wang, Junhong; Tang, Bo; Liu, Xinjian; Wu, Xin; Wang, Hui; Xu, Di; Guo, Yan

doi:10.1016/j.atherosclerosis.2015.01.024

Cited by 57 publications

(65 citation statements)

References 23 publications

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“…It also reflects the extent of myocardial injury in STEMIs. Wang et al 47 found that serum CRP was increased in patients with AMI suggesting that circulating CRP is a potential diagnostic biomarker. Despite some positive results, CRP is not considered to have sufficient specificity and sensitivity for use as a reliable diagnostic marker 48 49…”

Section: Summary Of Cardiac Biomarkersmentioning

confidence: 99%

Diagnostic and prognostic value of biomarkers in acute myocardial infarction

Chen

Tao

Zhang

et al. 2019

Postgraduate Medical Journal

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The incidence of acute myocardial infarction (AMI) has been increasing rapidly in recent years, seriously endangering human health. Cardiac biomarkers play critical roles in the diagnosis and prognosis of AMI. Troponin is a highly sensitive and specific biomarker for AMI diagnosis and can independently predict adverse cardiac events. Other biomarkers such as N-terminal B-type natriuretic peptide and C reactive protein are also valuable predictors of cardiovascular prognosis. Recently, several novel biomarkers have been identified for the diagnosis and risk assessment in patients with AMI. A multibiomarker approach can potentially enhance the diagnostic accuracy and provide more information for the early risk stratification of AMI. In this review, we will summarise the biomarkers discovered in recent years and focus on their diagnostic and prognostic value for patients with AMI.

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Section: Summary Of Cardiac Biomarkersmentioning

confidence: 99%

Diagnostic and prognostic value of biomarkers in acute myocardial infarction

Chen

Tao

Zhang

et al. 2019

Postgraduate Medical Journal

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“…In recent years, CRP has been used as a biomarker for cardiovascular disease, and its concentration can be used as a risk indicator for predicting acute myocardial infarction or stroke in healthy individuals. 24 CRP was significantly elevated in the middle-and high-dose groups, indicating severe heart damage that increased with increasing LDS dose. The systemic inflammatory factors LDH, TNF-α, and IL-6 were also elevated to different degrees in the LDS-exposed groups.…”

Section: Discussionmentioning

confidence: 95%

Effects of lunar dust simulant on cardiac function and fibrosis in rats

et al. 2019

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“…A wide variety of in vitro and ex vivo monomeric CRP (mCRP) conformers have been reported, ranging from the in vitro denatured mCRP produced by high concentrations of urea (up to 8 M) (20) through reduced membrane bound mCRP (21) to the hybrid mCRP with near native structure (22). Monoclonal antibodies for the various conformers have been generated, including those targeting neoepitopes revealed by pCRP subunit dissociation, and used to identify monomeric forms as distinct from pCRP (23)(24)(25). The urea dissociated mCRP of Potempa et al (20) remains very much the prototypical mCRP, being used in a wide variety of studies for over 30 years.…”

Section: Introductionmentioning

confidence: 99%