The authors wish to make the following corrections to their paper [...]

Two major challenges of current photodynamic therapy (PDT) are the limited tissue penetration of excitation light and poor tumor-selectivity of the photosensitizer (PS). To address these issues, we developed a multifunctional nanoconstruct consisting of upconversion nanoparticles (UCNPs) that transform near-infrared (NIR) light to visible light and a photosensitizer zinc(II) phthalocyanine (ZnPc). Folate-modified amphiphilic chitosan (FASOC) was coated on the surface of UCNPs to anchor the ZnPc close to the UCNPs, thereby facilitating resonance energy transfer from UCNPs to ZnPc. Confocal microscopy and NIR small animal imaging demonstrated the enhanced tumor-selectivity of the nanoconstructs to cancer cells that overexpressed folate receptor. Reactive oxygen species (ROS) generation in cancer cells under a 1-cm tissue was higher upon excitation of UCNPs with the 980 nm light than that with 660 nm irradiation. In vivo PDT treatments for deep-seated tumors demonstrated that NIR light-triggered PDT based on the nanoconstructs possessed remarkable therapeutic efficacy with tumor inhibition ratio up to 50% compared with conventional visible light-activated PDT with a noticeable reduced tumor inhibition ratio of 18%. These results indicate that the multifunctional nanoconstruct is a promising PDT agent for deep-seated tumor treatment and demonstrate a new paradigm for enhancing PDT efficacy.

The decays of the B, meson are calculated systematically by introducing a suitable approach. The obtained results are discussed and compared with those obtained by other approaches. PACS numberk): 14.40.Nd, 13.20.He, 13.25.Hw, 14.40.Lb 0556-2821/94/49(7)/3399(13)/%06.00 -49 3399

Supporting informationSynthesis and Optical Properties of CIS Core QDs. The temporal evolutions of both absorption

BackgroundPhysicians’ poor mental health not only hinders their professional performance and affects the quality of healthcare provided but also adversely affects patients’ health outcomes. Few studies in China have evaluated the mental health of physicians. The purposes of this study are to quantify Chinese physicians’ anxiety and depressive symptoms as well as evaluate associated risk factors.MethodsIn our study, 2641 physicians working in public hospitals in Shenzhen in southern China were recruited and interviewed by using a structured questionnaire along with validated scales testing anxiety and depressive symptoms. Multivariable logistic regression models were used to identify risk factors for anxiety and depressive symptoms.ResultsAn estimated 25.67% of physicians had anxiety symptoms, 28.13% had depressive symptoms, and 19.01% had both anxiety and depressive symptoms. More than 10% of the participants often experienced workplace violence and 63.17% sometimes encountered it. Among our study population, anxiety and depressive symptoms were associated with poor self-reported physical health, frequent workplace violence, lengthy working hours (more than 60 hours a week), frequent night shifts (twice or more per week), and lack of regular physical exercise.ConclusionsOur study demonstrates that anxiety and depressive symptoms are common among physicians in China, and the doctor-patient relationship issue is particularly stressful. Interventions implemented to minimize workload, improve doctor-patient relationships, and assist physicians in developing healthier lifestyles are essential to combat anxiety and depressive symptoms among physicians, which may improve their professional performance.

Based on a reliable mechanism, the cross sections of the B , hadronic production at the TeV energies of the CERN SppS, Fermilab Tevatron, CERN LHC, and SSC, as well as their possible fixed target experiments, are calculated. The results are presented numerically and indicate that the cross sections at the energies reached at the Tevatron, LHC, and SSC or higher are sufficiently large for further considering experimental studies of the B , meson at these colliders. PACS number(s1: 13.85.Ni, 12.38.Bx, 14.40.J~ The physics of the B, meson is very interesting, due to the nature of its structure. Comparing it with 77,,J/3, and v b , Y , etc., the B, meson, on one hand the same as them, is a double heavy-quark-antiquark bound state, so the QCD-inspired potential model should work well, and, on the other hand different from them, it carries flavors explicitly; thus it may decay by the weak interaction only, and has a much longer lifetime than the others [I-3,151. The B, meson (or its antiparticle) probably is the only object having the above twofold nature in the hadron world if there are only three generations of fundamental fermions as indicated by the standard model, and a very heavy top m , indicated by 140 GeV. The reason is as follows: In addition to the c 6 o r Sb bound states, of the three families a double heavy-quark-antiquark system with this feature must contain a top or top antiquark inside. However, the top quark probably would not have time to form any hadron before decaying itself: The lowest bound of the top quark mass is proved up to m , ? 91 GeV [7] now, and the top's lifetime will become shorter as the bound is increasing. It is easy to estimate that m, 2 140 GeV happens to be the case that the top quark would not have time to form any hadron before decaying itself. Therefore the B,, as well as its antiparticle, probably is the unique object having this nature. The properties of the meson B, may potentially make it become a fruitful "laboratory" for testing potential models and understanding the weak decay mechanism for heavy flavors.The reason the experimental study of B, physics has not really started yet, interesting though the physics may be, is due to the difficulty of producing the B, mesons. The difficulty may be understood by inspecting the following most possible mechanisms of the production. The first is to produce the meson B, or its antiparticle B, by the so-called fragmentation mechanism. In fact it is practically impossible by this mechanism to produce a number of the mesons, although it is very important for *Mailing address. the production of the single heavy mesons (with one heavy quark and one light quark) such as D O , Do, D', D -, D , , &, B +, B -, B O , and Po, etc. The reason is that the possibility to create a pair of heavy quarks from the vacuum (in the B, production case) is much smaller than that to create a pair of light ones (in the latter case). According to the hadron string model [4], the relative possibilities for producing quark pairs of various flavors from the v...

We present a general method for calculating inclusive cross sections for the production of heavy quarkonium states with definite polarization within the NRQCD factorization approach. Cross sections for polarized production can involve additional matrix elements that do not contribute to cross sections for unpolarized production. They can also include interference terms between parton processes that produce QQ pairs with different total angular momentum. The interference terms cancel upon summing over polarizations.Our method can be generalized to N dimensions and is therefore compatible with the use of dimensional regularization to calculate radiative corrections.We illustrate the method by applying it to the production of J/ψ via the parton processes qq → cc and gg → cc.

Computations of the production of B, or 6 mesons and their excited states B: or B : associated with two heavy-quark jets in Z 0 decay are presented in detail within the QCD-inspired potential model framework. The results show that the mesons B, and will soon be accessible experimentally in 2' decay.