Increased Mitotic Activity of the Parafollicular Cells of the Dog Thyroid in Experimentally Induced Hypercalcemia

Kameda, Yoko

doi:10.1679/aohc1950.32.179

Cited by 45 publications

(28 citation statements)

References 18 publications

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“…In normal dogs, the present study generally confirms the findings previously reported by the author at both light and electron microscope levels (KAMEDA, 1968(KAMEDA, , 1971(KAMEDA, , 1973.…”

Section: Controlssupporting

confidence: 93%

Relationship between the Thyroid Parafollicular Cells and Pituitary Gland

Kameda

1974

Arch. Histol. Jap., Arch. Histol. Jpn

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Section: Controlssupporting

confidence: 93%

Relationship between the Thyroid Parafollicular Cells and Pituitary Gland

Kameda

1974

Arch. Histol. Jap., Arch. Histol. Jpn

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“…The reduction in the parathyroid hormone release by enhanced blood calcium contents induced inactivity of the parathyroid gland leading to degeneration of few cells. Degeneration of parathyroid gland has also been noticed after experimental hypercalcemia in snakes RANI, 1992a, SRIVASTAV et al, 1994) and other vertebrates (KAMEDA, 1970;NUNEZ et al, 1974;SWARUP and SRIVASTAV, 1979;KOYAMA et al, 1984).…”

Section: Discussionmentioning

confidence: 94%

“…In reptiles, the parathyroid and ultimobranchial glands have been the subject of extensive research (CLARK 1965,1971a, b, 1983, SEHE 1965, OGURO 1969, 1970, 1972, SENIOR 1974, CLARK and LAVERTY 1985, CLARK et al 1986, YAMADA et al 2001, SRIVASTAV et al 1995, 1998, however, the effects of 1,25(OH) 2 D 3 (biologically active metabolite of vitamin D) on these glands in reptiles have not been investigated. Hence, in this study we have made an attempt to investigate the effects of 1,25(OH) 2 D 3 on the plasma calcium and inorganic phosphate levels as well as on the histological changes in the ultimobranchial and parathyroid glands of the Indian garden lizard, Calotes versicolor.…”

Section: Introductionmentioning

confidence: 99%

1,25(OH)2D3 Induced Alterations in Plasma Calcium, Inorganic Phosphate, Ultimobranhial Gland and Parathyroid Gland of the Garden Lizard, Calotes Versicolor

Srivastava¹,

Mishra²,

Srivastav³

et al. 2008

Zoologica Poloniae

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Abstract. Garden lizards Calotes versicolor were procured and given daily intraperitoneal injections of 30 pmol of 1,25(OH) 2 D 3 /50 g body wt for 30 days. Lizards were sacrificed on the 1 st , 3 rd , 5 th , 10 th , 15 th and 30 th day of the experiment. The plasma calcium levels of C. versicolor remain unaffected after day 1 following 1,25(OH) 2 D 3 treatment. After day 3 the levels increase significantly which progresses up to day 10. Thereafter, the plasma calcium level tends to decrease on day 15 and the levels become normal at day 30. In 1,25(OH) 2 D 3 injected lizards the plasma inorganic phosphate levels remain unaltered up to day 3. After day 5, the value increases significantly. This increase progresses up to day 15. On day 30, the levels become almost normal. The ultimobranchial gland exhibits hyperactivity following 5 day 1,25(OH) 2 D 3 treatment which is expressed by an increase in the nuclear volume and weak staining response of the cytoplasm of ultimobranchial cells. After day 10, the nuclear volume is further increased and some of the cells are exhausted. Following 15 days 1,25(OH) 2 D 3 treatment the nuclear volume records an increase and many degenerating cells are discerned. After day 30, the nuclear volume is almost normal, most cells seem to be recovered and only a few degenerating cells are noticed. After day 10 and day 15 following 1,25(OH) 2 D 3 treatment, the parathyroid glands of C. versicolor show reduced chromaticity of nuclei and a progressive decrease in the nuclear volume of parathyroidal cells. On day 30, the nuclear volume tends to become normal and a few degenerating cells are observed.

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“…In dogs, as in other mammals, the concentration of circulating CT increases after intravenous as well as after oral Ca administration (58). Both the synthesis and the secretion of CT are stimulated by a rise in plasma Ca as well as by food ingestion; hormones of the gastrointestinal tract, including gastrin, sti- (50,73,108). Because CT concentrations decrease during the first half year of life (58), age has to be taken into account when interpreting CT concentrations in young dogs.…”

Section: Skeletal Mineralizationmentioning

confidence: 99%

Growth and skeletal development in the dog in relation to nutrition; a review

Nap

Hazewinkel

1994

Veterinary Quarterly

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response of blood polymorphonuclear leukocytes to predict severity of Escherichia coli mastitis. J Dairy Sci 1993; 76: 1568-74 The biochemistry, synthesis, secretion, target organs, and effects of these endogenous factors are reviewed, and the calcium homeostatic mechanisms, dietary intake, bone turnover, and calcium excretion are discussed.Energy, protein, and calcium are nutritional factors of great importance to (skeletal) growth. The effects of low and high dietary intake of these nutrients are discussed, especially with reference to longitudinal growth and dis! turbances in endochondral ossification.

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Increased Mitotic Activity of the Parafollicular Cells of the Dog Thyroid in Experimentally Induced Hypercalcemia

Cited by 45 publications

References 18 publications

Relationship between the Thyroid Parafollicular Cells and Pituitary Gland

Relationship between the Thyroid Parafollicular Cells and Pituitary Gland

1,25(OH)2D3 Induced Alterations in Plasma Calcium, Inorganic Phosphate, Ultimobranhial Gland and Parathyroid Gland of the Garden Lizard, Calotes Versicolor

Growth and skeletal development in the dog in relation to nutrition; a review

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