Increased mast cell numbers in the conjunctiva of glaucoma patients: a possible indicator of preoperative glaucoma surgery inflammation

Chang, Lydia; Wong, Tina; Ohbayashi, Masaharu; Bunce, Catey; Barton, Keith; Ono, Santa Jeremy; Khaw, PT

doi:10.1038/eye.2008.330

Cited by 19 publications

(13 citation statements)

References 15 publications

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“…Conjunctival scarring is associated with the degree of inflammation. Chang et al (14) found the presence of significantly increased mast cell in patients with previous surgery for glaucoma compared with their control group. The degree of pulmonary inflammation following lung injury is associated with the number of mast cell activated (15).…”

Section: Inflammationmentioning

confidence: 96%

The role of mast cells in wound healing

Ng¹

2010

International Wound Journal

105

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Mast cells are predominantly found in the vicinity of connective tissue vessels of skin and mucosa. The main immunological functions of mast cells are in IgE-mediated reactions and in helminth infestations. Mast cells respond to tissue injury by releasing inflammatory mediators and have been implicated in diseases of excessive fibrosis of the dermis such as scleroderma. Current evidence suggests that mast cells exert its role during inflammation and cellular proliferation. Animal models have shown that by stabilising mast cells at the early stages of wound healing, wound contraction is reduced. Mast cells are an ideal candidate to play a pivotal role in wound healing due to its location, substances released and clinical associations.

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Section: Inflammationmentioning

confidence: 96%

The role of mast cells in wound healing

Ng¹

2010

International Wound Journal

105

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“…In uveitic glaucoma, excessive granulomatous response may occur and peripheral anterior synechia or pre-iris membrane may grow after glaucoma surgery, resulting in increased migration of the tube. [17][18][19] In glaucoma after penetrating keratoplasty, the change in the structure of the angle and peripheral anterior synechia after penetrating keratoplasty may result in increased migration of the tube. 20 However, further study to reveal the exact reason may be needed.…”

Section: Discussionmentioning

confidence: 99%

Serial intracameral visualization of the Ahmed glaucoma valve tube by anterior segment optical coherence tomography

Park

Jung

Park

2012

Eye

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“…Inflammation is a known risk factor for scarring after glaucoma surgery, 9 and Mahale et al also found dysregulation of several genes expressing inflammatory cytokines and chemokines ( CCL11 , IL13 , IL1A , IL1B , CXCR4 ). 8 Their results are supported by the work of Chang et al who found increased mast cell numbers in the conjunctival tissues of patients with previous glaucoma surgery that might be associated with an increased risk of conjunctival scarring 10 , 11 and previous findings that chronic treatment with eyedrops resulted in an increase in inflammatory cells and an increased chance of surgical failure. 12 , 13 …”

Section: Discussionmentioning

confidence: 64%

Personalized Medicine in Ocular Fibrosis: Myth or Future Biomarkers

Yu‐Wai‐Man

Khaw

2016

Advances in Wound Care

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Significance: Fibrosis-related events play a part in the pathogenesis or failure of treatment of virtually all the blinding diseases around the world, and also account for over 40% of all deaths. It is well established that the eye and other tissues of some group of patients, for example Afro-Caribbean people, scar worse than others. However, there is a current lack of reliable biomarkers to stratify the risk of scarring and postsurgical fibrosis in the eye.Recent Advances: Recent studies using genomics, proteomics, metabolomics, clinical phenotyping, and high-resolution in vivo imaging techniques have revealed potential novel biomarkers to identify and stratify patients at risk of scarring in different fibrotic eye diseases.Critical Issues: Most of the studies, to date, have been done in animals or small cohorts of patients and future research is needed to validate these results in large longitudinal human studies. Detailed clinical phenotyping and effective biobanking of patient tissues will also be critical for future biomarker research in ocular fibrosis.Future Directions: The ability to predict the risk of scarring and to tailor the antifibrotic treatment regimen to each individual patient will be an extremely useful tool clinically to prevent undertreating, or exposing patients to unnecessary treatments with potential side effects. An exciting future prospect will be to use new advances in genotyping, namely next-generation whole genome sequencing like RNA-Seq, to develop a customized gene chip in ocular fibrosis. Successful translation of future biomarkers to benefit patient care will also ultimately require a strong collaboration between academics, pharmaceutical, and biotech companies.

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Increased mast cell numbers in the conjunctiva of glaucoma patients: a possible indicator of preoperative glaucoma surgery inflammation

Cited by 19 publications

References 15 publications

The role of mast cells in wound healing

The role of mast cells in wound healing

Serial intracameral visualization of the Ahmed glaucoma valve tube by anterior segment optical coherence tomography

Personalized Medicine in Ocular Fibrosis: Myth or Future Biomarkers

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