The role of mast cells in wound healing

Ng, Michael F Y

doi:10.1111/j.1742-481x.2009.00651.x

Cited by 105 publications

(78 citation statements)

References 33 publications

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“…On one hand, this inflammatory cell type seems to play an important role in the proliferation phase where angiogenesis is essential for provision of oxygen and nutrients to the nascent tissue. Similarly to M2 macrophages, mast cells release angiogenic growth factors, including VEGF and metalloproteinases that prepare surrounding tissue for angiogenesis during skin repair (44). In fact, the rich content of M2 macrophages and mast cells strongly suggests a connection with the high levels of VEGF and high number of capillaries in the wounds of GF animals.…”

Section: Discussionmentioning

confidence: 99%

Skin Wound Healing Is Accelerated and Scarless in the Absence of Commensal Microbiota

Canesso

Vieira

Castro

et al. 2014

The Journal of Immunology

150

126

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The commensal microbiota has a high impact on health and disease by modulating the development and homeostasis of host immune system. Immune cells are involved in virtually every aspect of the wound repair process; however, the impact of commensal microbiota on skin wound healing is largely unknown. In this study, we evaluated the influence of commensal microbiota on tissue repair of excisional skin wounds by using germ-free (GF) Swiss mice. We observed that macroscopic wound closure rate is accelerated in the absence of commensal microbiota. Accordantly, histologically assessed wound epithelization was accelerated in GF in comparison with conventional (CV) Swiss mice. The wounds of GF mice presented a significant decrease in neutrophil accumulation and an increase in mast cell and macrophage infiltration into wounds. Interestingly, alternatively activated healing macrophage-related genes were highly expressed in the wound tissue of GF mice. Moreover, levels of the anti-inflammatory cytokine IL-10, the angiogenic growth factor VEGF and angiogenesis were higher in the wound tissue of those mice. Conversely, scarring and levels of the profibrogenic factor TGF-β1 were greatly reduced in GF mice wounded skin when compared with CV mice. Of note, conventionalization of GF mice with CV microbiota restored wound closure rate, neutrophil and macrophage accumulation, cytokine production, and scarring to the same extent as CV mice. Overall, our findings suggest that, in the absence of any contact with microbiota, skin wound healing is accelerated and scarless, partially because of reduced accumulation of neutrophils, increased accumulation of alternatively activated healing macrophages, and better angiogenesis at wound sites.

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Section: Discussionmentioning

confidence: 99%

Skin Wound Healing Is Accelerated and Scarless in the Absence of Commensal Microbiota

Canesso

Vieira

Castro

et al. 2014

The Journal of Immunology

150

126

View full text Add to dashboard Cite

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“…Mast cells have been hypothesized to have important roles in wound healing, where they degrade the extracellular matrix and release angiogenic peptides and cause contraction of the wound bed via the action of specific proteases, such as chymases and tryptases (15). Mast cells have been shown previously to synthesize laminin, type IV collagen, and perlecan.…”

mentioning

confidence: 99%

Mast Cells Produce Novel Shorter Forms of Perlecan That Contain Functional Endorepellin

Jung

Lord

Bai

et al. 2013

Journal of Biological Chemistry

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Background: Mast cells modulate events in wound healing. Results: Shorter forms of perlecan are produced by mast cells via proteolytic processing and alternative splicing, which contain domain V and functional endorepellin. Conclusion:The production of these shorter forms modulates endothelial cell adhesion, proliferation, and migration. Significance: Mast cells produce specific forms of perlecan that affect endothelial cell behavior.

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“…The role of mast cells in healing has been widely discussed in the scientific community in recent years. Different scientific studies confirm the participation of these cells effectively at all stages of healing 11,12 . This study aimed to quantify the mast cells in different stages of healing and correlate them with the degree of contraction of cutaneous wounds in rats treated with 10% X. americana extract.…”

mentioning

confidence: 80%

Mast cell concentration and skin wound contraction in rats treated with Ximenia americana L

et al. 2017

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Purpose: To evaluate wound contraction and the concentration of mast cells in skin wounds treated with wild plum (Ximenia americana) essential oil-based ointment in rats. Methods: Sixty rats were submitted to two cutaneous wounds in the thoracic region, on the right and left antimeres. Thereon, they were divided into three groups: GX (wounds treated once a day with hydro alcoholic branch extract of Ximenia amerIcana), GP (wounds that received vehicle), and GC (wounds without product ap-plication). Wounds were measured immediately after the injury as well as 4, 7, 14 and 21 days post-topical application of the extract. At these days, five rats from each group were euthanatized. Thereafter, samples were fixed in 10% formalde-hyde and processed for paraffin embedding. Sections were stained with H.E, Masson's Trichrome and toluidine blue for morphological, morphometrical and histopathological analysis, under light microscopy. The degree of epithelial con-traction was measured and mast cell concentrations were also evaluated with an image analyzer (Image Pro-plus®software). Results: The extract treated group showed lower mast cell concentrations in the 4th day of lesion, as compared to GP (GX GP = GC; p<0.05). Conclusion: Ointment containing 10% X. americana induces a decrease in mast cell concen-tration, at the beginning of the healing process, and promotes early skin wound contraction in rats.

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The role of mast cells in wound healing

Cited by 105 publications

References 33 publications

Skin Wound Healing Is Accelerated and Scarless in the Absence of Commensal Microbiota

Skin Wound Healing Is Accelerated and Scarless in the Absence of Commensal Microbiota

Mast Cells Produce Novel Shorter Forms of Perlecan That Contain Functional Endorepellin

Mast cell concentration and skin wound contraction in rats treated with Ximenia americana L

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