Increased liver alkaline phosphatase and aminotransferase activities following administration of ethanolic extract of &lt;i&gt;Khaya senegalensis&lt;/i&gt; stem bark to rats

Yakubu, Musa Toyin; Adebayo, Oluwatope J; Egwim, Evans Chidi; Owoyele, Bamidele Victor

doi:10.4314/biokem.v17i1.32585

Cited by 38 publications

(32 citation statements)

References 10 publications

(4 reference statements)

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“…Serum alkaline phosphatase activity is a very useful serum biochemical indicator of liver disease (Lawal et al, 2016). The significant increase in serum ALP activities in untreated rats when compare with those treated with the extract confirm the earlier report that infection could gradually affect enzyme level (Kennedy, 2004) by increase activation of the enzyme molecule in situ and release of membrane component (including alkaline phosphatase) into the extracellular fluids (Yakubu et al, 2005). However, rat treated with methanol extract of M. domestica (early treated group and prophylactic treated group) shows ameliorative effect as it cause significant decrease in the serum activities of the elevated ALP.…”

Section: Discussionsupporting

confidence: 80%

Effect of Methanol extract of Musca domestica larva on some Enzymes and Haematological parameters in Trypanosoma brucei brucei - infected rats

Shittu¹,

Lawal²,

Adeniyi³

et al. 2018

Nig J Bas App Sci

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This study investigated the effect of methanol extract of Musca domestica (400mg/kg body weight) on some biomarker enzymes and haematological parameters in Trypanosoma brucei brucei -infected rats. Twenty albino rats were intraperitoneally infected with Trypanosoma brucei brucei and were grouped into five (5) groups of four (4) rats each. Group1 was set up as infected not treated (0.2ml normal saline/kg body weight), group 2 was treated with diaminazene aceturate (standard drug), group 3 as prophylactic treated (treatment for 72 hours before inoculation of parasite), group 4 as early treatment with the extract (treatment commenced after the sight of parasite) and group 5 as the control (uninfected untreated) group. Results shows significant (p<0.05) decrease in liver AST and ALT activities with concomitant increase in serum activities of the infected untreated rats when compared with the early treated, prophylactic treated, standard treated and normal control. Serum ALP activity of the infected not treated group was significantly (p<0.05) higher when compared to the control group and other experimental groups. No significant (p>0.05) difference in the liver ALP activities of the extract treated infected groups with standard drug treated group However, serum and liver GGT activities of the uninfected untreated (control) was significantly lower (p<0.05) than all the other experimental groups. Haematological studies shows significant decrease (p<0.05) in packed cell volume (PCV) , haemoglobin concentration (Hb) and red blood cell count (RBC) of infected not treated when compared to infected prophylactic treated and infected early treated. There was likewise significant increase in white blood cell count (WBC) of infected not treated compared to infected prophylactic treated and infected early treated. Findings from this study showed that methanol extract of Musca domestica larva has trypanocidal properties thereby ameliorating the T. brucei induced biochemical changes in rats.

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Section: Discussionsupporting

confidence: 80%

Effect of Methanol extract of Musca domestica larva on some Enzymes and Haematological parameters in Trypanosoma brucei brucei - infected rats

Shittu¹,

Lawal²,

Adeniyi³

et al. 2018

Nig J Bas App Sci

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“…The Automated Haematologic Analyzer (Sysmex, KX-21, Japan) was used to analyse the haematological parameters of red blood cells (RBC), haemoglobin (Hb), packed cell volume (PCV), Mean corpuscular haemoglobin (MCH), mean corpuscular haemoglobin concentration (MCHC), large unstained cell (LUC), red cell width coefficient of variation (RDW-CV), white blood cell (WBC), mean platelet volume (MPV), platelet distribution width (PDW) and platelets. The levels of other parameters were determined as described for bilirubin (total and conjugated) [22] , total protein [23] , albumin [24] , globulin, sodium, calcium and potassium [25], whereas the activities of ALT and AST, GGT and ALP were determined using standard methods [26][27][28] .…”

Section: Determination Of Biochemical Parametersmentioning

confidence: 99%

Toxicity profile of ethanolic extract of Azadirachta indica stem bark in male Wistar rats

Ashafa

Orekoya

Yakubu

2012

Asian Pacific Journal of Tropical Biomedicine

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“…Depending on the volume of damage (cytolysis) liver cells released equal amounts of enzyme-markers related to hepatocyte damage viz cytoplasmic alanine and aspartate aminotransferase (ALT and AST) etc into the bloodstream (Singh et al, 2011). Specific determinants hepatocyte cytolysis is ALT activity, observed as some increase AST (Yakubu et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Effect of Laurus nobilis extract on the functioning of liver against ccl4 induced toxicity

Gasparyan¹,

Tiratsuyan²,

Kazaryan³

et al. 2015

JEBAS

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KEYWORDS Laurus nobilis Biochemical markers CCl4Hystochemistry Toxic hepatitis ABSTRACTIn present study effect of laurel leaf extract (Laurus nobilis) on biochemical parameters and histomorphology of rat liver induced by toxic damage of CCl4 was studied. Introduction of CCl4 in animals was always carried out in fatal to 36 hours. A single injection of the L. nobilis extract ssimultaneously with CCl4 leads to 100% survivability. To evaluate the degree of hepatocyte damage in experimental modeling hepatitis de Ritis index was used. It has been reported that intraperitoneal injection of a lethal dose of CCl4 activates hepatocyte damage in the key markers, such as alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, γ -glutamiltransferase, bilirubin, urea, albumin, glucose, cholesterol, triacylglycerides. Simultaneous treatment of CCl4 with Laurus nobilis leaves extract prevented death and exhibit a normalizing effect on the main indicators of liver damage and index de-Ritis. Result of the present study revealed that L. nobilis extract have capacity to manage metabolic and histological abnormalities of hepatocytes toxic damage induced by CCl4.

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Increased liver alkaline phosphatase and aminotransferase activities following administration of ethanolic extract of <i>Khaya senegalensis</i> stem bark to rats

Cited by 38 publications

References 10 publications

Effect of Methanol extract of <i>Musca domestica</i> larva on some Enzymes and Haematological parameters in <i>Trypanosoma brucei brucei</i> - infected rats

Effect of Methanol extract of <i>Musca domestica</i> larva on some Enzymes and Haematological parameters in <i>Trypanosoma brucei brucei</i> - infected rats

Toxicity profile of ethanolic extract of Azadirachta indica stem bark in male Wistar rats

Effect of Laurus nobilis extract on the functioning of liver against ccl4 induced toxicity

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