Increased Level of Advanced Oxidation Products (Aopp) as a Marker of Oxidative Stress in Patients With Acute Coronary Syndrome

Abstract

Oxidative stress impairs endothelial function and may play an important role in the pathogenesis of acute cardiovascular diseases. Advanced oxidation protein products (AOPP) were proposed as one of the possible markers of oxidative injury, which originates under oxidative and carbonyl stress and increase global inflammatory activity. The present study was undertaken to compare AOPP concentrations in a control group of healthy individuals without ICHS (I), patients with stable angina pectoris (II), patients with acute coronary syndrome over 48 hours without ST elevations (III), and patients with ST elevation myocardial infarction (IV). Coronaronary angiography, risk factors and anamnestic data were analyzed. We examined 73 probands with signs of myocardial ischemia, mean age of 61.5 years (64 % males) subjected to coronarography and 21 healthy individuals. No significant difference was found between venous blood and coronary samples, or between infarction and non-infarction arteries in the group IV. AOPP concentrations in healthy individuals in the group I (82.9 ± 29.3 mmol/l) did not differ significantly from patients in group II (89.6 ± 26.7 mmol/l) and group III (112.3 ± 54.6 mmol/l). A significant difference in AOPP values was found between the groups I and IV, and between the groups II and IV (82.9 ± 29.3 mmol/l vs. 125.8 ± 101 mmol/l, p = 0.02, and 89.6 ± 26.7 mmol/l vs. 125.8 ± 101 mmol/l, p = 0.02). No correlations were found between AOPP and body mass index (BMI), nicotinism, left ventricular ejection fraction, parameters of glucose and lipid metabolism. ROC analysis revealed that AOPP concentrations of 89 mmol/l had 64 % sensitivity and 71 % specificity for revealing an acute coronary syndrome (AUC 0.65, 95 % CI 0.55-0.80). AOPP are significantly increased in patients with acute coronary syndromes with ST segment elevation, but also tend to increase in patients with non-ST elevation myocardial infarction. Our observations suggest that AOPP may be used as a marker of oxidative stress and as a prognostic factor for severe forms of cardiovascular disease. A cutoff value of 89 mmol/l can be used with 64 % sensitivity and 71 % specificity for revealing acute coronary syndrome.

Advanced oxidation protein products and malondialdehyde — the new biological markers of oxidative stress — are elevated in postmenopausal women

“…The value of AOPP assay as a marker for cardiovascular risk was reported in three other studies [15][16][17]. In two of these, the study populations were formed of non-uremic patients [15,17].…”

“…AOPPs are proposed as one of the possible markers of oxidative injury, which originate under oxidative and carbonyl stress and increase global inflammatory activity. Recently, elevated AOPP levels have also been reported to be associated with increased cardiovascular risk [15][16][17].…”

Oxidative Stress and Kidney Glycation in Rats Exposed Cadmium

“…This selective relationship between AOPP and monocyte activation was further established with positive correlations between AOPP and TNF-α and its soluble receptors, and, to a lesser degree, with IL-1Ra, although these correlations tended to be of only borderline significance when values were corrected for creatinine clearance [22].…”

“…Since AOPP formation is optimal with chlorinated oxidants, it is interesting to speculate that its formation in vivo might result from enzymatic activity of phagocyte-derived Myelopeoxidase (MPO) [22].…”

“…Methylglyoxals are estimated according to the modified method of Racker [22]. Twenty-five μl of samples was added to 350 μl of DNPH [0.1% DNPH in 2N HCl].…”