Oxidative Stress and Kidney Glycation in Rats Exposed Cadmium

Suhartono, Eko

doi:10.7763/ijcea.2014.v5.435

Cited by 8 publications

(8 citation statements)

References 27 publications

(39 reference statements)

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“…Increase of AOPP reflected increase in the formation of H 2 O 2 , enhancement myeloperoxidase activity; and increasing reactivity of free radical to biomolecules containing the amino groups, such as protein in the cell structure [8,17].…”

Section: Resultsmentioning

confidence: 99%

“…In addition, formed superoxide anion modulated the production of TNF-, which was one of the proinflammatory factor. Between AOPP and TNF- showed strong positive correlation, so AOPP could be used as inflammation parameter of the kidney [17,23]. Besides as inflammation and oxidative stress parameters, AOPP also played important role as cellular homeostasis.…”

Section: Issn 2087-2852 E-issn 2338-1655mentioning

confidence: 99%

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Effects of Cadmium Exposure on Lipid Peroxidation and Chlorinative Stress of Rat Kidney

Suhartono

Triawanti

Leksono

2015

JELS

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In addition to a wide range of adverse effects on human health, toxic metals such as cadmium (Cd) can promote kidney damage. In this study, we proposed the toxicological properties of these metals which are partly related to lipid peroxidation and chlorinative stress. Thus our study aimed to measure the lipid peroxidation and chlorinative stress in kidney of rats exposed to Cd. The study was performed on 32 male rats (Rattus novergicus) weighing 300±10 grams with normal activity. Rats were acclimatized for a week before the treatment. The animals were divided into two major groups with one group for control (K 0 ) and the other groups were exposed to 3 mg/L CdSO 4 through the drinking water. The animals in each groups were divided again into two small groups with different time of exposure. The time of exposure are subacute (six weeks) and subchronic (eight weeks). After the exposure the kidney from all treated animals showed the significant increase of MDA and AOPP levels. In conclusion, subacute and subchronic exposure of Cd caused the kidney damage through lipid peroxidation and chlorinative stress, as shown by increasing of MDA and AOPP levels.

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Section: Resultsmentioning

confidence: 99%

Section: Issn 2087-2852 E-issn 2338-1655mentioning

confidence: 99%

Effects of Cadmium Exposure on Lipid Peroxidation and Chlorinative Stress of Rat Kidney

Suhartono

Triawanti

Leksono

2015

JELS

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“…SOD activity was measured by Misra and Fridovich method. MDA level of the homogenate was measured by the Buege and Aust method [10]. Carbonyl compound level in homogenate are estimated according by the DNPH method with slight modification [11].…”

Section: Biochemical Analysismentioning

confidence: 99%

Oxidative Stress on Buccal Mucosa Wound in Rats and Rule of Topical Application of Ethanolic Extracts of Mauli Banana (Musa acuminata) Stem

Noor¹,

Aprianti²,

Saputra³

et al. 2015

JTLS

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The present study was undertaken to evaluate the effect of a topical application of ethanolic extracts of Mauli banana stem on oxidative status in buccal mucosa wounds of rats. The sets involved three groups, P0 was the negative control; P1 was treated with alocair topically; and P2 was treated with ethanolic extracts of Mauli banana stem topically, respectively, 24h after wound creation for 3 days. The oxidative stress status was evaluated by monitoring the SOD, CAT activity, MDA and CC levels. Ethanolic extracts of Mauli banana stem showed significantly increased in SOD activity, decreased in MDA levels, and no significant change both in CAT activity and CC levels compared to negative control. These results showed that The ethanolic extracts of Mauli banana stem might affect the oxidative stress status during wound healing process.

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“…There are several, well-researched theories of how chronic hyperglycemia can lead to micro or macrovascular disease in diabetes including the advanced glycation end product (AGE) theory [6]. AGE represent a heterogeneous class of compounds formed through nonenzymatic reaction between reducing sugars and proteins, known as glycation [7], [8].…”

Section: Introductionmentioning

confidence: 99%

Antidiabetic and Antioxidant Activity of Jackfruit (Artocarpus Heterophyllus) Extract

Biworo¹,

Tanjung²,

Iskandar³

et al. 2015

JOMB

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The Artocarpus heterophyllus (Jackfruit) is a species of tree of the mulberry family Moraceae. The plants of Artocarpus species have been used by traditional folk medicine in Indonesia. can be useful as anti-bacterial, antidiabetic, anti-inflammatory, antioxidant and anti-helmintics. The present study was aimed to evaluate antidiabetic and antioxidant activity of aqueous extract of Jackfruit. The antidiabetic activity were determined by inhibition of haemoglobin glycation method. Phytochemical constituent like ascorbic acid, -carotene and lycopene also determined. Antioxidant activity was measured by hydroxl radical and hydrogen peroxide scavenging activity, and chellating effect of ferrous iron. From the result of this study we can see the increasing of haemoglobin glycation concentration is followed by the increasing of jackfruit extracts concentration. From this study also we found the IC 50 of jackfruit exctracts is 56,43 %. The result of this study also showed that the extract of jackfruit has a phytochemical constituent with ascorbic acid is the highest, and followed by -carotene and lycopene. Jackfruit also has antioxidant activity. The highest antioxidant activity is scavenging hydroxyl radical activity and followed by scavenging hydrogen peroxide and chellating of ferrous iron. The result of this study suggest that the jackfruit extract potential as an diabetic agent. 

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Oxidative Stress and Kidney Glycation in Rats Exposed Cadmium

Cited by 8 publications

References 27 publications

Effects of Cadmium Exposure on Lipid Peroxidation and Chlorinative Stress of Rat Kidney

Effects of Cadmium Exposure on Lipid Peroxidation and Chlorinative Stress of Rat Kidney

Oxidative Stress on Buccal Mucosa Wound in Rats and Rule of Topical Application of Ethanolic Extracts of Mauli Banana (Musa acuminata) Stem

Antidiabetic and Antioxidant Activity of Jackfruit (Artocarpus Heterophyllus) Extract

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