Increased leptin/adiponectin ratio relates to low-normal thyroid function in metabolic syndrome

Tienhoven-Wind, Lynnda J. N. van; Dullaart, Robin P. F.

doi:10.1186/s12944-016-0403-4

Cited by 9 publications

(6 citation statements)

References 36 publications

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“…Significant positive correlations between leptin and TSH were observed in many studies [124][125][126]. A positive correlation between TSH and leptin/adiponectin ratio was recently reported [127]. Leptin/adiponectin ratio is considered to be a good marker of adipose tissue dysfunction, thus van Tienhoven-Wind et al's observations suggest a relationship between the HPT axis and impaired adipose tissue function.…”

Section: Interactions Between Adipocytokines and Thyroid Hormones/tshmentioning

confidence: 91%

Obesity and Thyroid Axis

Walczak

Siemińśka

2021

IJERPH

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Development of obesity is primarily the result of imbalance between energy intake and energy expenditure. Thyroid hormones influence energy expenditure by regulating cellular respiration and thermogenesis and by determining resting metabolic rate. Triiodothyronine influences lipid turnover in adipocytes and impacts appetite regulation through the central nervous system, mainly the hypothalamus. Thyroid-stimulating hormone may also influence thermogenesis, suppress appetite and regulate lipid storage through lipolysis and lipogenesis control. Subclinical hypothyroidism may induce changes in basal metabolic rate with subsequent increase in BMI, but obesity can also affect thyroid function via several mechanisms such as lipotoxicity and changes in adipokines and inflammatory cytokine secretion. The present study investigated the complex and mutual relationships between the thyroid axis and adiposity.

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Section: Interactions Between Adipocytokines and Thyroid Hormones/tshmentioning

confidence: 91%

Obesity and Thyroid Axis

Walczak

Siemińśka

2021

IJERPH

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“…It was explained upon the level of adipocytokines, mainly leptin, released from the adipocytes. Leptin affects thyroid centrally through the activation of thyrotropin-releasing hormone [ 34 , 35 ] and, peripherally, by promoting the conversion of T4 to T3 [ 36 ]. However, TSH also increase the leptin production which depends on the adiposity mass [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

Impact of Weight Reduction on Thyroid Function and Nonalcoholic Fatty Liver among Egyptian Adolescents with Obesity

Amin

Ali²,

El-Sayed

2022

International Journal of Endocrinology

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Background. The prevalence of childhood obesity has been increasing worldwide. This may explain the emergence of nonalcoholic fatty liver as the leading cause of liver disease. Several previous studies have addressed the association between thyroid function and nonalcoholic fatty liver disease. Objectives. To study the impact of weight reduction through lifestyle modifications in adolescents with obesity. Methods. A prospective cohort study was done on 61 adolescents with obesity. Patients were evaluated at the first visit by the full history, clinical examination, and investigations (thyroid profile, lipid profile, liver function tests, HbA1c, and liver ultrasonography) as basal information. The intervention program included a dietary program, increasing physical activity, and decreasing sedentary activity. A postintervention evaluation was done at the end of six months which included anthropometric measures, laboratory results, and ultrasonographic estimation. Results. It was shown that the mean BMI of the participants had significantly decreased after lifestyle modification from (32.05 ± 3.36 kg/m2) to (28.1 ± 2.77 kg/m2) ( P < 0.001 ). It also showed that the percentage of studied adolescents with elevated TSH decreased from 47.5% to 19.7% after the weight reduction program. Improvement was also achieved in the lipid profile and liver functions. The percentage of studied adolescents with ultrasound appearance of NAFLD decreased from 31.1% to 26.2% after weight reduction. Conclusions. Lifestyle modification positively influences the metabolic derangement in obesity without medical treatment. ΔTSH is a significant predictor of the change in BMI z-score. It is also possible that hepatic steatosis affects thyroid function rather than the other way around.

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“…2017 stated that a rise in TSH level inward the euthyroid range allows an increased Leptin/adiponectin ratio in MetS persons, which prospective contributes toward a negative cardiac profile in these patient cohorts. [ 56 ]…”

Section: Discussionmentioning

confidence: 99%

Thyroid Function Assessment in Saudi Males with Metabolic Syndrome

Aldhafiri

Abdelgawad

Bakri

et al. 2021

Journal of Pharmacy and Bioallied Sciences

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Background: Metabolic Syndrome (MetS) is a multifactor condition associated with cardiovascular risk. Thyroid hormones regulate MetS components via controlling energy homeostasis, lipids, and glucose metabolism. The risk ratio for MetS and related disorders changes between males and females. Aim and Objectives: Study aim to access thyroid functions in Saudi population with metabolic syndrome. Materials and Methods: The current study sought to evaluate the impact of thyroid stimulating hormone (TSH), free triiodothyronine (FT3), and free thyroxine (FT4) in predicting the risk of MetS. A total of 200 (MetS 100 and control 100) Saudi Arabian males were enrolled for the study, and after applying eligibility criteria, the eligible study size was examined for the physical test (chest, abdominal, and general examination with stress on blood pressure measurement) and anthropometric parameters (bodyweight, body mass index, and waist circumference). Results: In the present study, the biochemical parameters, such as TSH, FT3, FT4, total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL), high-density lipoprotein (LDL), fasting glucose, and fasting insulin were measured in the study group, and statistical analysis was also performed. The results revealed that the MetS and control differ in terms of physical, anthropometric, and biochemical markers. The study showed that thyroid dysfunction (TD) and MetS are closely associated with the difference in physical, anthropometric, and metabolic characteristics. Conclusion: The result demonstrated hypothyroidism major risk factor due to TD in MetS. These findings provide a scientific basis for diagnosis and the management of TD, associated MetS, and cardiovascular disease (CVD).

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Increased leptin/adiponectin ratio relates to low-normal thyroid function in metabolic syndrome

Cited by 9 publications

References 36 publications

Obesity and Thyroid Axis

Obesity and Thyroid Axis

Impact of Weight Reduction on Thyroid Function and Nonalcoholic Fatty Liver among Egyptian Adolescents with Obesity

Thyroid Function Assessment in Saudi Males with Metabolic Syndrome

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