Thyroid Function Assessment in Saudi Males with Metabolic Syndrome

Abstract

Background: Metabolic Syndrome (MetS) is a multifactor condition associated with cardiovascular risk. Thyroid hormones regulate MetS components via controlling energy homeostasis, lipids, and glucose metabolism. The risk ratio for MetS and related disorders changes between males and females. Aim and Objectives: Study aim to access thyroid functions in Saudi population with metabolic syndrome. Materials and Methods: The current study sought to evaluate the impact of thyroid stimulating hormone (TSH), free triiodothyronine (FT3), and free thyroxine (FT4) in predicting the risk of MetS. A total of 200 (MetS 100 and control 100) Saudi Arabian males were enrolled for the study, and after applying eligibility criteria, the eligible study size was examined for the physical test (chest, abdominal, and general examination with stress on blood pressure measurement) and anthropometric parameters (bodyweight, body mass index, and waist circumference). Results: In the present study, the biochemical parameters, such as TSH, FT3, FT4, total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL), high-density lipoprotein (LDL), fasting glucose, and fasting insulin were measured in the study group, and statistical analysis was also performed. The results revealed that the MetS and control differ in terms of physical, anthropometric, and biochemical markers. The study showed that thyroid dysfunction (TD) and MetS are closely associated with the difference in physical, anthropometric, and metabolic characteristics. Conclusion: The result demonstrated hypothyroidism major risk factor due to TD in MetS. These findings provide a scientific basis for diagnosis and the management of TD, associated MetS, and cardiovascular disease (CVD).

Association of Thyroid Function With Lipid Profile in Patients With Metabolic Syndrome: A Prospective Cross-Sectional Study in the Indian Population

“…The mean insulin and HOMA-IR index in our patients with metabolic syndrome were 20.8±4.3 mU/mL and 5.8±1.3, respectively. Almost similar levels of mean insulin and HOMA-IR index were reported by Aldhafiri et al in patients with metabolic syndrome [16]. Compared to the findings of the current study, almost similar levels of FBS, serum TG, and HDL were reported by Khatiwada et al [17].…”

“…Meher et al reported similar outcomes [ 15 ]. A similar research was conducted by Aldhafiri et al, and the results showed that the mean systolic blood pressure and diastolic blood pressure were 130.44±2.82 and 88.17± 2.82 mmHg, respectively [ 16 ]. In the present study, we observed an elevated blood pressure in patients with metabolic syndrome as compared to patients without metabolic syndrome and a strong positive correlation of both systolic and diastolic blood pressure with TSH levels and a negative correlation with T3 levels.…”