Obesity and Thyroid Axis

Walczak, Krzysztof; Siemińśka, Lucyna

doi:10.3390/ijerph18189434

Cited by 76 publications

(67 citation statements)

References 137 publications

(241 reference statements)

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“…Obese people with a normal thyroid gland tend to have higher serum TSH and thyroid hormones in serum due to the activation of hypothalamic-pituitary-thyroid axis. 24 In the present study, the mean TSH value was found to be statistically significantly higher in overweight/ obese participants (p=0.02). On the other hand, lipid and glycemic parameters were significantly different in overweight/obese group as expected since their relationships with BMI and obesity are well-known.…”

Section: Discussionsupporting

confidence: 46%

Investigation of serum neprilysin levels in overweight and normal weight young women

Cander

Gül

2022

Turkish Journal of Internal Medicine

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Background In this study we aimed to evaluate biochemical, lipid and glycemic parameters and to compare serum neprilysin levels between overweight (OW) and normal weight (NW) young women who are more prone to gain weight. Material and Methods A total of 28 overweight/obese women aged between 22-34 years and 34 age matched normal-weight women were included in this cross-sectional study on voluntary basis. of the subjects were performed, Participants' anthropometric measurements, hormone profiles, glycemic parameters and insulin resistance, and serum neprilysin levels were recorded and analyzed. Patients were evaluated in two groups as Group OW and Group NW. Results The mean ALT, TSH and uric acid values were statistically significantly higher in Group OW compared to Group NW (for all, p<0.05). The mean HDL-c was statistically significantly lower in Group OW than in Group NW (p<0.01), while the mean triglyceride level was significantly higher in Group OW than in Group NW (p=0.002). The mean fasting blood glucose, insulin, HOMA, HbA1c and triglyceride values were statistically significantly higher in Group OW compared to Group NW (for all, p<0.001). The mean neprilysin (NEP) value was found as 1123.44±1327.60 mmol/L in Group NW and 1229.39±1315.17 mmol/L in Group OW with no statistically significant difference between the groups. No significant correlation was found between NEP and BMI values. Conclusions In this study, no significant difference was found between serum neprilysin levels of overweight/obese and normal weight women, suggesting that neprilysin does not play a role in the pathogenesis of obesity, insulin resistance or diabetes.

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Section: Discussionsupporting

confidence: 46%

Investigation of serum neprilysin levels in overweight and normal weight young women

Cander

Gül

2022

Turkish Journal of Internal Medicine

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“…Theories had been generated to illustrate the thyroid dysfunction in obese patients [ 33 ]. It was explained upon the level of adipocytokines, mainly leptin, released from the adipocytes.…”

Section: Discussionmentioning

confidence: 99%

“…However, TSH also increase the leptin production which depends on the adiposity mass [ 37 ]. Elevated TSH may also trigger low-grade chronic inflammation [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

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Impact of Weight Reduction on Thyroid Function and Nonalcoholic Fatty Liver among Egyptian Adolescents with Obesity

Amin

Ali²,

El-Sayed

2022

International Journal of Endocrinology

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Background. The prevalence of childhood obesity has been increasing worldwide. This may explain the emergence of nonalcoholic fatty liver as the leading cause of liver disease. Several previous studies have addressed the association between thyroid function and nonalcoholic fatty liver disease. Objectives. To study the impact of weight reduction through lifestyle modifications in adolescents with obesity. Methods. A prospective cohort study was done on 61 adolescents with obesity. Patients were evaluated at the first visit by the full history, clinical examination, and investigations (thyroid profile, lipid profile, liver function tests, HbA1c, and liver ultrasonography) as basal information. The intervention program included a dietary program, increasing physical activity, and decreasing sedentary activity. A postintervention evaluation was done at the end of six months which included anthropometric measures, laboratory results, and ultrasonographic estimation. Results. It was shown that the mean BMI of the participants had significantly decreased after lifestyle modification from (32.05 ± 3.36 kg/m2) to (28.1 ± 2.77 kg/m2) ( P < 0.001 ). It also showed that the percentage of studied adolescents with elevated TSH decreased from 47.5% to 19.7% after the weight reduction program. Improvement was also achieved in the lipid profile and liver functions. The percentage of studied adolescents with ultrasound appearance of NAFLD decreased from 31.1% to 26.2% after weight reduction. Conclusions. Lifestyle modification positively influences the metabolic derangement in obesity without medical treatment. ΔTSH is a significant predictor of the change in BMI z-score. It is also possible that hepatic steatosis affects thyroid function rather than the other way around.

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“…It is unclear whether the altered thyroid function present in obesity is due to the excess adiposity or, alternatively, the decreased thyroid function is the cause of the excess adiposity. The thyroid axis regulates the adipose tissue and the adipose tissue affects the activity of the thyroid axis [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Thyroid Function Alteration in Obesity and the Effect of Bariatric Surgery

Cordido

Juiz-Valiña

Urones

et al. 2022

JCM

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The most common endocrine disease in obesity is hypothyroidism and secondary endocrine alterations, including abnormal thyroid function, are frequent in obesity. It is unclear whether impaired thyroid function is the cause or the consequence of increased adiposity; furthermore, there are no clear data regarding the best way to dose levothyroxine for patients with both hypothyroidism and obesity, and the effect of bariatric surgery (BS). The aim of the present article is to review some controversial aspects of the relation between obesity and the thyroid: (1) Thyroid function in obesity and the effect of BS (2) Thyroid hormone treatment (THT) in obese patients with hypothyroidism and the effect of BS. In summary: In morbidly obese patients, TSH is moderately increased. Morbid obesity has a mild central resistance to the thyroid hormone, reversible with weight loss. In morbidly obese hypothyroid patients, following weight loss, the levothyroxine dose/kg of ideal weight did not change, albeit there was an increment in the levothyroxine dose/kg of actual weight. From a clinical practice perspective, in morbid obesity, diagnosing mild hypothyroidism is difficult, BS improves the altered thyroid function and THT can be adapted better if it is based on ideal weight.

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Obesity and Thyroid Axis

Cited by 76 publications

References 137 publications

Investigation of serum neprilysin levels in overweight and normal weight young women

Investigation of serum neprilysin levels in overweight and normal weight young women

Impact of Weight Reduction on Thyroid Function and Nonalcoholic Fatty Liver among Egyptian Adolescents with Obesity

Thyroid Function Alteration in Obesity and the Effect of Bariatric Surgery

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