Increased Ki-67 proliferative index and absence of P16INK4 in CIN-HPV related pathogenic pathways different from cervical squamous intraepithelial lesion

Kuo, Kuan‐Ting; Chang, Hsiao-Ching; Hsiao, Chen-Hsiang; Lin, Ming-Chieh

doi:10.1136/bjo.2005.086314

Cited by 30 publications

(24 citation statements)

References 44 publications

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“…The procedures were performed as previously described [6]. Each polymerase chain reaction (PCR) amplification reaction was carried out in a total volume of 50 μL containing a PCR master mixture (10 mmol/L Tris-HCl, pH 8.3, 50 mmol/L KCl, 800 μmol/L each of dATP, dCTP, dGTP, 600 μmol/L dUTP, 10 pmol of each primer set, 1.25 IU/L, AmpliTaq Gold DNA polymerase; Applied Biosystems, San Francisco, CA).…”

Section: Hpv Detection By Nested Polymerase Chain Reaction and Hpv Gementioning

confidence: 99%

Papillary squamous intraepithelial lesions of the uterine cervix: human papillomavirus-dependent changes in cell cycle expression and cytologic features

et al. 2010

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Section: Hpv Detection By Nested Polymerase Chain Reaction and Hpv Gementioning

confidence: 99%

Papillary squamous intraepithelial lesions of the uterine cervix: human papillomavirus-dependent changes in cell cycle expression and cytologic features

et al. 2010

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“…6 After entering key words 'Pterygia' and 'HPV' into PubMed and further refining the search to include only original articles written in English that assessed four or more biological samples from patients with pterygia, 18 articles were selected. Eleven investigations detected HPVs, [27][28][29][30][31][32][33][34][35][36][37] whereas other studies were unable to detect the virus [38][39][40][41][42][43][44] ( Figure 1a and Table 1). From these 18 studies, the average prevalence for HPV was 18.6% (range 0-100%), corresponding to 136/731 positive specimens ( Figure 1a).…”

Section: Pterygia: Characteristics and Pathogenic Mechanismsmentioning

confidence: 99%

“…From the 42 studies identified, 16 studies were appropriate after applying the same inclusion/exclusion criteria used to assess associations between HPV and pterygium. From these investigations, 9 successfully detected HPV by various techniques, 31,38,44,[53][54][55][56][57][58] whereas the remaining were unsuccessfully 39,43,[59][60][61][62][63] ( Figure 1b and Table 2). From these 16 studies, an average prevalence rate of 33.8% (range 0-100%) was observed, representing 144/426 HPV-positive specimens (Figure 1b).…”

Section: Pterygia: Characteristics and Pathogenic Mechanismsmentioning

confidence: 99%

Association of human papilloma virus with pterygia and ocular-surface squamous neoplasia

Girolamo

2011

Eye

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There are more microorganisms that colonize the human body than resident cells; some are commensal whereas others are pathogenic. Pathogenic microorganisms are sensed by the innate or adaptive immune system, an immune response is initiated, and the infection is often cleared. Some microorganisms have developed strategies to evade immune defenses, ensuring their long-term survival with potentially devastating consequences for the host. Approximately 18% of all cancers can be attributed to infective agents; the most common being Helicobacter pylori, Human papilloma virus (HPV) and Hepatitis B and C virus in causing stomach, cervical and liver carcinoma, respectively. This review focuses on whether HPV infection is necessary for initiating pterygia, a common benign condition and ocular-surface squamous neoplasia (OSSN), a rare disease with metastatic potential. The search engine PubMed was used to identify articles from the literature related to HPV and pterygium or conjunctival neoplasia. From 34 investigations that studied HPV in pterygia and OSSN, a prevalence rate of 18.6% (136/731) and 33.8% (144/426), respectively, was recorded. The variation in HPV prevalence (0-100%) for both disease groups may have arisen from study-design faults and the techniques used to identify the virus. Overall, the data suggest that HPV is not necessary for initiating either condition but may be a co-factor in susceptible hosts. Currently, over 60 million people worldwide have been immunized with HPV vaccines, but any effect on pterygium and OSSN development may not be known for some time as these lesions can evolve over decades or occur in older individuals.

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“…This study also showed that there was no statistical significance of P53-positive cells in CIN lesion compared to non-CIN lesions and normal conjunctiva due to the wide standard deviations. (Kuo et al 2006) Therefore, Ki-67 PI may serve as a meaningful diagnostic marker for OSSN. …”

Section: Immunohistochemical Analysis: Ki-67 Proliferative Indexmentioning

confidence: 99%

Ocular Surface Squamous Neoplasia

Tananuvat¹,

Lertprasertsuke²

2012

Intraepithelial Neoplasia

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Increased Ki-67 proliferative index and absence of P16INK4 in CIN-HPV related pathogenic pathways different from cervical squamous intraepithelial lesion

Cited by 30 publications

References 44 publications

Papillary squamous intraepithelial lesions of the uterine cervix: human papillomavirus-dependent changes in cell cycle expression and cytologic features

Papillary squamous intraepithelial lesions of the uterine cervix: human papillomavirus-dependent changes in cell cycle expression and cytologic features

Association of human papilloma virus with pterygia and ocular-surface squamous neoplasia

Ocular Surface Squamous Neoplasia

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