Papillary squamous intraepithelial lesions of the uterine cervix: human papillomavirus-dependent changes in cell cycle expression and cytologic features

Liang, Cher‐Wei; Lin, Ming-Chieh; Hsiao, Chen-Hsiang; Lin, Yi-Ting; Kuo, Kuan-Ting

doi:10.1016/j.humpath.2009.05.015

Cited by 8 publications

(11 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The immature condyloma is a variant of LSIL of the uterine cervix that presents histologically as an immature metaplasia with papillary morphology, which is also associated with HPV infection 1. By comparison with conventional condyloma, the immature condyloma exhibits slender and filiform papillary cells with the absence of koilocytotic atypia.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Non HPV-related cervical squamous cell carcinoma with unusual histologic characteristics mimicking a giant immature condyloma: a case report

Tsai¹,

Kuo²,

Chen³

et al. 2013

J Clin Pathol

Self Cite

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

“…The immature condyloma, also named papillary immature metaplasia or papillary squamous intraepithelial lesion, is a rare form of low-grade squamous intraepithelial lesions (LSIL) of the uterine cervix 1. This lesion is usually associated with HPV types 6 and 11.…”

Section: Introductionmentioning

confidence: 99%

Non HPV-related cervical squamous cell carcinoma with unusual histologic characteristics mimicking a giant immature condyloma: a case report

Tsai¹,

Kuo²,

Chen³

et al. 2013

J Clin Pathol

Self Cite

View full text Add to dashboard Cite

“…In addition, cases classified as LSIL, but showing areas of Papillary Immature Metaplasia (PIM or "immature condyloma"), a distinct pathological subtype of LSIL, were identified [26] , [27] , [28] , [29] , [30] . PIM is not specifically addressed in the LAST classification, however, its recognition is important because it is a distinct subset of exophytic LSIL, typically p16-negative, but with a potential to mimic HSIL, which is recognized by the LAST [10] , [28] .…”

Section: Methodsmentioning

confidence: 99%

“…PIM is not specifically addressed in the LAST classification, however, its recognition is important because it is a distinct subset of exophytic LSIL, typically p16-negative, but with a potential to mimic HSIL, which is recognized by the LAST [10] , [28] . PIM lesions showed papillae with thin fibrovascular cores, lined by immature squamous cells, with only low levels of mitosis in basal cells, and typically showing CK7 positive columnar cells on the surface [26] , [27] , [28] , [29] , [30] . To further assess the mixed population of columnar and basal squamous cells often found in PIM lesions we performed p63 immunostaining, in addition with CK7, for selected cases.…”

Section: Methodsmentioning

confidence: 99%

Squamous intraepithelial lesions of the anal squamocolumnar junction: Histopathological classification and HPV genotyping

Clavero

McCloskey

Molina

et al. 2017

Papillomavirus Research

View full text Add to dashboard Cite

BackgroundHuman papillomavirus (HPV)-related anal cancer lesions are often found adjacent to the squamocolumnar junction (SCJ). We have assessed the histopathology and associated HPV genotypes in anal SCJ lesions in surgically excised anal warts in HIV-negative and –positive patients.MethodsHistopathology identified 47 squamous intraepithelial lesions (SILs) adjacent to the SCJ amongst a total of 145 cases of clinically diagnosed anal condylomata. The anal SCJ lesions were further analyzed with p16, CK7 and p63 immunohistochemistry and HPV genotyping.ResultsSixteen (16/47) of the excised anal wart lesions contained HSIL; Three were HSIL and exclusively associated with oncogenic HPVs. A further thirteen (13/47) were mixed lesions. Of these eight were HSILs with LSIL and six were HSILs with papillary immature metaplasia (PIM); Ten of the mixed lesions were associated with one or more oncogenic HPVs, while three cases were exclusively associated with HPV6.ConclusionsClinically diagnosed anal warts cannot be assumed to be limited to low-grade lesions as anal warts of the SCJ often show heterogeneous lesions, with coexistence of LSIL, PIM, and HSIL. Lesions showing PIM, however, may mimic HSIL, because they are hypercellular, but lack the nuclear atypia and conspicuous mitotic activity of HSIL; and are p16 negative.

show abstract

“…Максимальную продукцию реплицированных копий ДНК ВПЧ определяет экспрессия вирусных белков Е6 и Е7 [15], воздействие которых на семейства клеточных бел-ков р53 [17], pRb [10,17,18], р16 [19,20] и р21 [21] исклю-чает возможность остановки цикла клетки для репарации ее ДНК или запуска апоптоза при возникающих при ре-пликации ДНК мутаций ее генов [22]. В М фазе клеточно-го цикла связь Е7 ВПЧ с ядерным белком митотического аппарата -nuclear mitotic apparatus protein (NuMA 1), на-рушает механизм асимметричного митоза базальных кле-ток [23], необходимого для их последующей дифференци-ровки [24].…”

unclassified

Nuclear mitotic apparatus changes as a sign of cervical neoplasia associated with high-risk human papillomavirus

Ершов¹,

Chirsky²,

Lisyanskaya³

2015

Onkol. Z. im. P.A. Gercena

View full text Add to dashboard Cite

24Рак шейки матки (РШМ) -одна из ведущих при-чин смертности среди женщин во всем мире, несмотря на высокую информативность скрининга предшествующих цервикальных интраэпителиальных изменений [1]. Его основным этиологическим фактором считают вирус па-пилломы человека (ВПЧ), около 30 генотипов которого определяют при злокачественном поражении цервикаль-ного эпителия [2], что позволило выделить их в группу высокого канцерогенного риска (ВПЧ ВКР). Длительная персистенция этих ДНК-вирусов может послужить при-чиной развития РШМ, который занимает в мире второе [3], а в России -третье место в структуре онкологической заболеваемости женского населения [4].Согласно современной теории вирусного канцеро-генеза его пусковым механизмом считают интеграцию Цель исследования -изучение изменений ядерного митотического аппарата на разных стадиях ВПЧ-ассоциированной цервикальной неоплазии и определение возможности их использования в качестве критериев прогноза прогрессии эпите-лиальных изменений. Материал и методы. Исследованы 264 биоптата ВПЧ-позитивного цервикального эпителия цитоло-гическим, гистологическим, иммуноморфологическим методами и методом ПЦР. Результаты. При цервикальной неопла-зии, ассоциированной с вирусом папилломы человека высокого канцерогенного риска, отмечены различные повреждения ядерного митотического аппарата. При утяжелении повреждения плоского эпителия на фоне угнетения апоптоза возрас-тает митотический индекс, увеличивается количество многоядерных клеток, снижается экспрессия NuMA 1. Заключение. При низкой степени интраэпителиального повреждения плоского эпителия и сохранении механизма асимметричного ми-тоза изменения митотического аппарата приводят к нарушению цитотомии или многополюсности митоза. При высокой степени интраэпителиального повреждения плоского эпителия и плоскоклеточном раке к ним присоединяются грубые повреждения ядерного митотического аппарата в виде к-митозов. Отрицательная реакция NuMA 1 в клетках с патоло-гическими митозами и экспрессия этого белка менее чем в 1 / 3 клеток с типичными митозами могут служить критериями прогрессии цервикальной неоплазии. Ключевые слова: шейка матки, неоплазия, ВПЧ, ядерный белок митотического аппарата.Objective: to study nuclear mitotic apparatus changes at different stages of human papillomavirus (HPV)-associated cervical neoplasia and to determine whether they may be used as criteria for the prediction of progressive epithelial changes. Material and methods. Cytological, histological, and immunomorphological techniques and PCR were used to examine 264 high-risk HPVpositive cervical epithelial biopsy specimens. Results. Various nuclear mitotic apparatus lesions were noted in cervical neoplasia associated with high-risk HPV. When a squamous epithelial lesion got worse in the presence of suppressed apoptosis, there were increases in mitotic index and multinucleated cells with the decreased expression of nuclear mitotic apparatus protein 1 (NuMA 1). Conclusion. In low-grade squamous intraepithelial lesion with the preserved mechanism of asymmetric mitosis, ...

show abstract

Papillary squamous intraepithelial lesions of the uterine cervix: human papillomavirus-dependent changes in cell cycle expression and cytologic features

Cited by 8 publications

References 25 publications

Non HPV-related cervical squamous cell carcinoma with unusual histologic characteristics mimicking a giant immature condyloma: a case report

Non HPV-related cervical squamous cell carcinoma with unusual histologic characteristics mimicking a giant immature condyloma: a case report

Squamous intraepithelial lesions of the anal squamocolumnar junction: Histopathological classification and HPV genotyping

Nuclear mitotic apparatus changes as a sign of cervical neoplasia associated with high-risk human papillomavirus

Contact Info

Product

Resources

About