Ocular Surface Squamous Neoplasia

Tananuvat, Napaporn; Lertprasertsuke, Nirush

doi:10.5772/32238

Cited by 10 publications

(19 citation statements)

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“…It is nearly impossible to categorise OSSN as benign or malignant based on clinical appearance alone. Most of the studies noticed that OSSN tumours appear as sessile, fleshy, elevated lesion near the limbus in the inter-palpebral region [9][ FIGURE 4]. In another study from the Southern part of this country Radhakrishnan et al noticed that out of all the morphological types, the gelatinous type is most common and presents usually as a well-circumscribed raised mass with a smooth surface [19].…”

Section: Discussionmentioning

confidence: 99%

“…These tumours are considered to be low grade malignancies but invasive lesions can spread to the globe or orbit [9]. They present with different morphological types-leukoplakic, papillary, gelatinous, and nodular or Manuscript received: 10 th February 2016 Reviewed: 24 h February 2016 Author Corrected; 8 th March 2016 Accepted for Publication: 20 th March 2016 diffuse lesions.…”

Section: Introductionmentioning

confidence: 99%

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Clinicopathological analysis of 55 cases of ocular surface squamous neoplasia

Kabra¹,

Morawala²,

Maheshwari³

2016

Trop J Ophthalmol Otolaryngol

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Introduction: The aim of this observational study is to review the presenting clinical features and histopathology of 55 cases of OSSN, at a tertiary care institute in Western India. Method: The study enrolled patients from the in-patient department. The workup included a detailed history with Slit-lamp examination, clinical photographs and histopathological analysis of tissue samples taken via incisional or en-block excisional biopsy. Results: The mean age of the patients was 38.2 years. 25.4% of patients were HIV reactive, with an average age of 26.8 years. The most common presenting complaints were redness, watering and foreign body sensation occurring in 59.9% of the cases. 29% patients were asymptomatic or presented with complaints of a whitish mass lesion. Morphologically, the commonest lesion was of the Leukoplakic variety (32.72% of cases). On histopathological analysis, 41.8% of cases showed intraepithelial carcinoma, with mild dysplasia in a majority of cases. Invasive carcinoma was seen in 58.18% of cases, with poorly differentiated cells in a majority of them. Conclusion: We conclude from the study that the affected population is younger in our region of the world, than in the West. HIV screening would help identify occult cases of HIV which present only with OSSN. Increased awareness of this disease among ophthalmologists would help ensure an early and definitive diagnosis.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Clinicopathological analysis of 55 cases of ocular surface squamous neoplasia

Kabra¹,

Morawala²,

Maheshwari³

2016

Trop J Ophthalmol Otolaryngol

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“…The mutagenic effect of UVB is related to a combination of UVB induced DNA damage, primarily in the p53 tumour suppressor gene, and impaired DNA repair mechanisms [5,[10][11][12][13]. It has been found that spending more than 50% of time outdoors in the first 6 years of life and living within 30 degrees of the equator are UVB induced risk factors for OSSN [14].…”

Section: Risk Factorsmentioning

confidence: 99%

Observational study of ocular surface squamous neoplasia: Risk factors, diagnosis, management and outcomes at a tertiary eye hospital in South Africa

2020

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Background Ocular surface squamous neoplasia (OSSN) is the most common ocular surface tumour. Diagnosis and management have traditionally been by excision biopsy. Recently there has been success with the use of topical chemo or immunotherapy, which has resulted in a move from invasive diagnosis by histology to an array of non-invasive diagnostic tests. Methods This observational study aims to describe the characteristics of patients with OSSN at St John Eye Hospital in Johannesburg, South Africa. Non-invasive diagnostic tests (impression cytology, anterior segment-OCT, methylene blue staining) will be compared to the gold standard, histology. Treatment success, recurrence and adverse events will be documented between three treatment options that include: surgical excision, topical 5-Fluorouracil (5FU) chemotherapy, and topical 5FU with retinoic acid therapy. Discussion There is a trend to the use of less invasive diagnosis and management for OSSN. Minimally invasive diagnostic tests include cytology, anterior-segment OCT and methylene blue staining. The study will compare these to the gold standard histology, thereby providing evidence for their use in clinical practice. Interferon alpha 2b is commonly used as immunotherapy for OSSN. The cost of this medication is prohibitive to its adoption in a developing country. We therefore decided to use 5FU as the chemotherapeutic agent of choice in this study. The success, adverse events and recurrence rates with this agent may provide additional evidence for its use in the management of OSSN. Overall, if diagnosis and management can be implemented with good success in the outpatient environment, care can be improved for this condition in a developing country.

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“…These tumours are considered to be low grade malignancies but invasive lesions can spread to the globe or orbit. 17 The standard modality for treatment of OSSN has been wide surgical excision with "no-touch" technique 18 and adjunctive cryotherapy. However, due to high recurrence rates ranging from 5% to 66% after surgical excision, 19 nonsurgical management with topical chemotherapeutic agents (5-fluorouracil) and mitomycin C (MMC) has become the preferred choice for management of OSSN.…”

Section: Introductionmentioning

confidence: 99%

Management of OSSN by different modalities of treatment

Khan¹,

Kochar²,

Khan³

2021

IJOOO

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To study the Ocular surface squamous (OSSN) neoplasm in terms of demographics, clinical presentation, histopathology and treatment. Materials and Methods: This is a histopathological hospital based prospective comparative interventional case series carried out in the Department of Ophthalmology, S.P. Medical College and associated group of hospital in collaboration with Pathology Department.. The study was carried out from December, 2017 to December, 2019. The study included 22 consecutive cases of OSSN of either age and sex. In our study three groups were formed based on different modalities for treatment of OSSN-Surgery plus Mitomycin [MMC] (0.04%) 4 cycles, Surgery ,Only MMC (0.04%) 4 cycles.Results: OSSN was found with greater frequency in male patients (male/female ratio: 2.7/1), residents of rural area (rural/urban ratio: 3.4/1), older age group (mean age ± SD: 54.10±13.17) and those engaged in outdoor activity. On Histopathological examination 15 cases 68.18% were reported with squamous cell carcinoma, 5 cases (22.73%) with severe dysplasia and two cases (9.09) with carcinoma in-situ. Surgery plus MMC was the most effective mode of treatment in these neoplasia. Conclusion : Surgery plus MMC was the most effective mode of treatment in OSSN. These types of tumours can be treated with only mitomycin-c in cases where surgery was challenging. Young patients presenting with OSSN must be screened for HIV.

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Ocular Surface Squamous Neoplasia

Cited by 10 publications

References 91 publications

Clinicopathological analysis of 55 cases of ocular surface squamous neoplasia

Clinicopathological analysis of 55 cases of ocular surface squamous neoplasia

Observational study of ocular surface squamous neoplasia: Risk factors, diagnosis, management and outcomes at a tertiary eye hospital in South Africa

Management of OSSN by different modalities of treatment

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