Increased ischemia-modified albumin and malondialdehyde levels in videothoracoscopic surgery

Abstract

BACKGROUND:Videothoracoscopic surgery leads to general organ hypoperfusion by reducing mean arterial pressure, systemic vascular resistance, and end-diastolic volume index. Oxidative stress occurs as a result of hypoperfusion. Evaluation of the short-term effects of videothoracoscopic sympathectomy on serum ischemia-modified albumin (IMA), malondialdehyde (MDA), and nitric oxide (NO) levels in patients with primary hyperhidrosis was aimed.METHODS:Twenty-six patients who underwent videothoracoscopic surgery were contributed in this study. Venous blood samples were obtained from these patients 1 h before and after the surgery. IMA, MDA, and NO levels were measured in serum samples by colorimetric methods. Albumin concentrations were also measured for each sample, and albumin-adjusted IMA levels were calculated.RESULTS:Postoperative IMA, albumin-adjusted IMA, and MDA values were significantly higher compared to the preoperative values (P = 0.003, 0.027, 0.018, respectively). However, postoperative NO levels were lower than the preoperative values (P = 0.002). There was no significant difference between pre- and postoperative albumin concentrations, and there was no significant correlation between the parameters tested.CONCLUSIONS:We can conclude that elevation in MDA and IMA levels after videothoracoscopic surgery was caused by increased oxidative stress due to minimal ischemia-reperfusion injury after the infusion of CO2 during the surgical process. Videothoracoscopic sympathectomy operation causes a decrease in NO production, and this should be taken in consideration when evaluating nitrosative stress in videothoracoscopic surgery.

Reappraisal of ischemia-reperfusion injury in a short duration laparoscopic surgery, a pilot study

“…Regarding the inability of the endogenous markers used in this study to detect mild I/R changes, several explanations are possible, including the use of markers that do not reflect entirely and correctly the biochemical reactions that follow PP. As is evident according to many studies, in humans as well as in animals, consensus (whether there is significant oxidative stress during laparoscopic surgery) has not yet been established due to diverse biomarkers heterogeneity, different study designs, and various methods of detection, which makes meta-analysis impossible [ 19 – 24 , 31 – 36 ].…”