Changes in Thiol-Disulfide Homeostasis of the Body to Surgical Trauma in Laparoscopic Cholecystectomy Patients

Polat, Murat; Özcan, Önder; Sahan, Leyla; Ustundag-Budak, Yasemin; Alışık, Murat; Yılmaz, Nigar; Erel, Özcan

doi:10.1089/lap.2016.0381

Cited by 12 publications

(9 citation statements)

References 32 publications

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“…In a study investigating effect of elective laparoscopic cholecystectomy and open inguinalfemoral hernia repair operation on TDH, the authors have demonstrated that during operation, NT, TT and disulfide levels were found to be decreased. Additionally, 24 hours after laparoscopic surgery, NT, TT and disulfide levels were found to be increased but not return to preoperative levels [120].…”

Section: Other Disordersmentioning

confidence: 84%

Thiol-disulfide homeostasis: an integrated approach with biochemical and clinical aspects

Erel

Erdoğan

2020

Turk J Med Sci

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Dynamic thiol-disulfide homeostasis (TDH) is a new area has begun to attract more scrutiny. Dynamic TDH is reversal of thiol oxidation in proteins and represents the status of thiols (-SH) and disulfides (-S-S-). Organic compounds containing the sulfhydryl group is called thiol, composed of sulfur and hydrogen atoms. Disulfides are the most important class of dynamic, redox responsive covalent bonds build in between two thiol groups. For many years, thiol levels were analyzed by several methods. During last years, measurements of disulfide levels have been analyzed by a novel automated method, developed by Erel and Neselioglu. In this method, addition to thiol-termed as native thiol-levels, disulfide levels were also measured and sum of native thiol and disulfide levels were termed as total thiol. Therefore, TDH was begun to be understood in organism. In healthy humans, TDH is maintained within a certain range. Dysregulated dynamic TDH has been implicated several disorders with unknown etiology. A growing body of evidence has demonstrated that the thiol-disulfide homeostasis is involved in variety diseases, such as diabetes mellitus, hypertension, non-small cell lung cancer, Familial Mediterranean fever, inflammatory bowel diseases, occupational diseases, gestational diabetes mellitus and preeclampsia. These results may elucidate some pathogenic mechanism or may be a predictor indicating diagnostic clue, prognostic marker or therapeutic sign. In conclusion, protection of the thiol disulfide homeostasis is of great importance for the human being. Evidence achieved so far has proposed that thiol-disulfide homeostasis is an important issue needs to elucidate wholly.

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Section: Other Disordersmentioning

confidence: 84%

Thiol-disulfide homeostasis: an integrated approach with biochemical and clinical aspects

Erel

Erdoğan

2020

Turk J Med Sci

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“…The thiol-disulphide homeostasis situation has important responsibilities in antioxidant protection, apoptosis, signal transduction, detoxification, regulation of enzymatic activity, and cellular signalling mechanisms [20,21] . Furthermore, thiol-disulphide homeostasis is increasingly being evaluated in various medical conditions in humans, such as diabetes [22] , rheumatoid arthritis [23] , cancer [25] , multiple sclerosis [33] , hepatic disorders [24] , and surgery [34] . The plasma thiol pool is constituted by cysteine, GSH, homocysteine, and albumin.…”

Section: Discussionmentioning

confidence: 99%

Buzağılarda Sıcak Koter ile Boynuzsuzlaştırmanın Tiyol-Disülfit Homeostazı Üzerine Etkisi

Erdoğan¹,

Çamkerten²,

Çamkerten³

et al. 2018

Kafkas Univ Vet Fak Derg

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We aimed to examine the effect of hot-iron disbudding on serum thiol-disulphide homeostasis levels as a marker of oxidant stress in relationship with trauma in calves under sedation, local anaesthesia, and the non-steroidal anti-inflammatory drug ketoprofen. A total of 30 Holstein calves were enrolled in the study and allocated into three groups: disbudded following sedation with xylazine (n=10) (group I); disbudded following sedation (xylazine) and local anaesthesia with lidocaine (n=10) (group II); and disbudded after sedation (xylazine), local anaesthesia (lidocaine), and ketoprofen (n=10) (group III). Blood samples were withdrawn before (0. min) and 30, 60, 90, and 120 min after dehorning. Serum native thiols, total thiols, and disulphide levels were detected with a novel assay. Native thiol and total thiol levels were reduced in all groups without any significance during the study period. At the 90 th min of the study, native thiol levels in group II were significantly lower than in groups I and III. There were no significant alterations in total thiol levels in both groups. Disulphide levels showed no significant changes in group, time, and group by time interactions, but at the 60 th min, groups I and III had the lowest levels. Disulphite/ native thiol, disulphite/total thiol, and native thiol/total thiol levels had significant group alterations in the 60 th min. The reduction of native thiol and total thiol levels in all groups without significance might be related to the antioxidant activity of plasma; however, it is thought that the pain management procedures should be related to the sensitive oxidative balance by thiols.

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“…Determination of dynamic thiol‐disulphide homeostasis allows determining entire dynamic SH groups providing a benefit from determining only glutathione (GSH) level or redox couples (such as reduced/oxidised glutathione and cysteine/cystine) individually. There is limited published data concerning the effects of thiol/disulphide homeostasis in laparoscopic cholecystectomy surgeries 9‐11 . To the best of our knowledge, there is no published study to investigate the role of thiol/disulphide homeostasis in TPS and anaesthetic methods.…”

Section: Introductionmentioning

confidence: 99%

“…There is limited published data concerning the effects of thiol/disulphide homeostasis in laparoscopic cholecystectomy surgeries. [9][10][11] To the best of our knowledge, there is no published study to investigate the role of thiol/disulphide homeostasis in TPS and anaesthetic methods. Nitric oxide (NO) as a free radical can contribute to nitrosative stress, and mediates cellular signalling pathways that regulate a plethora of physiological processes.…”

mentioning

confidence: 99%

Comparison of serum dynamic thiol/disulphide homeostasis and nitric oxide levels of total intravenous vs inhaled anaesthesia in endoscopic transsphenoidal pituitary surgery

et al. 2021

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Background Transsphenoidal pituitary surgery (TPS) is traditionally performed under general anaesthesia. This study aimed to compare the effects of total intravenous anaesthesia (TIVA) or sevoflurane, an inhalation anaesthetic, on thiol‐disulphide homeostasis in patients undergoing endoscopic endonasal TPS. Methods In this study, 84 patients scheduled for TPS were randomly categorised into two groups: propofol (n = 42, the TIVA group) or sevoflurane (n = 42, the SEVO group). Blood samples were taken before induction of general anaesthesia and at the 30 minutes of postoperation. Serum native thiol and total thiol levels were detected, and the number of dynamic disulphide bonds and related ratios were calculated from these values. Serum nitric oxide (NO) levels were measured using a chemiluminescence method. Results Although native thiol levels in TIVA postoperation group were markedly increased (P < .05), total thiol levels in SEVO postoperation group were significantly decreased (P < .01). Disulphide levels were declined in both groups (P < .05 for TIVA and P = .001 for SEVO groups). Disulphide/native thiol (P < .05 for both groups) and disulphide/total thiol ratios (P < .05 for TIVA and P < .01 for SEVO groups) were depressed in postoperation groups. We found a marked elevation in native thiol/total thiol ratio in both groups (P < .05 for TIVA and P < .01 for SEVO groups). There was significant augmentation in serum NO levels in the SEVO postoperation group (P < .05). Conclusion These results are the first to show that both TIVA and sevoflurane showed similar antioxidant effect with reduced disulphide levels, but sevoflurane may offer more robust oxidative stress protection and augmented NO production than TIVA during TPS. However, the clinical effect is needed to further investigate.

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Changes in Thiol-Disulfide Homeostasis of the Body to Surgical Trauma in Laparoscopic Cholecystectomy Patients

Abstract: The decrease in plasma level of native and total thiol groups suggests impairment of the antioxidant capacity of plasma; however, the delicate balance between the different redox forms of thiols was maintained during surgery.

Cited by 12 publications

References 32 publications

Thiol-disulfide homeostasis: an integrated approach with biochemical and clinical aspects

Thiol-disulfide homeostasis: an integrated approach with biochemical and clinical aspects

Buzağılarda Sıcak Koter ile Boynuzsuzlaştırmanın Tiyol-Disülfit Homeostazı Üzerine Etkisi

Comparison of serum dynamic thiol/disulphide homeostasis and nitric oxide levels of total intravenous vs inhaled anaesthesia in endoscopic transsphenoidal pituitary surgery

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