Increased Interleukin-17 and decreased BAFF serum levels in drug-free acute schizophrenia

Kissi, Y. El; Samoud, S.; Mtiraoui, Abderraouf; Letaief, Leila; Hannachi, N.; Ayachi, M.; Ali, B. Ben Hadj; Boukadida, Jalel

doi:10.1016/j.psychres.2014.10.007

Cited by 38 publications

(33 citation statements)

References 52 publications

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“…At the onset of illness, TGF-β most likely plays an immunosuppressive role, and IL-23 may have pathogenic effects unrelated to IL-17. In contrast to our results and those of others (51), several reports have found an increase in serum IL17 in patients whose schizophrenia is in relapse and an increased activation of Th17 cells in the first episode of schizophrenia, with a decrease in Th17 cells after risperidone treatment (50,52). These differences may be due to the significantly shorter duration of illness in our study population, the possible predominance of IL-6 signalling pathways in later stages of schizophrenia (14), and the diverse effects of different antipsychotic drugs (21).…”

Section: Tgf-β In Schizophreniacontrasting

confidence: 99%

“…A meta-analysis of plasma cytokine alterations suggested that TGF-β is the state marker for acute exacerbation of schizophrenia (21) and that it can be a valuable marker for psychosis (22). Recent studies have questioned these findings and did not find a difference in the TGF-β serum levels between patients with schizophrenia and controls (50).…”

Section: Tgf-β In Schizophreniamentioning

confidence: 99%

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Possible Role of TGF – B Pathways in Schizophrenia / Moguća Uloga TTGF - B Signalnih Puteva U Shizofreniji

Borovcanin

Jovanović

Dejanovic

et al. 2016

Serbian Journal of Experimental and Clinical Research

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Section: Tgf-β In Schizophreniacontrasting

confidence: 99%

Section: Tgf-β In Schizophreniamentioning

confidence: 99%

Possible Role of TGF – B Pathways in Schizophrenia / Moguća Uloga TTGF - B Signalnih Puteva U Shizofreniji

Borovcanin

Jovanović

Dejanovic

et al. 2016

Serbian Journal of Experimental and Clinical Research

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“…Among the 9 articles, 2 studies by Borovcanin and colleagues published in 2012 [19] and 2013 [23] were based on the same sample, and 2 studies by Noto and colleagues published in 2014 [24] and 2015 [21] were also based on the same sample. Additionally, 2 studies included a mixture of samples of drug-naïve patients and those drug free for at least 3 months [12,25]. Because no stratified data was provided in the articles, we excluded these studies.…”

Section: Resultsmentioning

confidence: 99%

“…Th17 cell emerged as a new CD4+ cell subset, which infiltrates the central nervous system through the direct effects of its cytokine production [10]. Interleukin-17 (IL-17) is the product of Th17 cells and implicated in various immune and inflammatory processes [11], and there exists evidence supporting the association of IL-17 with schizophrenia [12,13]. It is being increasingly recognized that gut permeability may play a pivotal role in schizophrenia [14].…”

Section: Introductionmentioning

confidence: 99%

Interleukin-17 Alteration in First-Episode Psychosis: A Meta-Analysis

et al. 2017

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Schizophrenia is accompanied with central nervous system and peripheral immune system imbalances. Interleukin-17 (IL-17) is implicated in various immune and inflammatory processes. Aberrant levels of IL-17 have been reported in patients with schizophrenia, whereas the results are not consistent. To clarify the relationship between IL-17 and schizophrenia, we performed a meta-analysis in this study. We carried out a structured literature search in PubMed and Embase database up to April 16, 2017, and retrieved all eligible case-control studies according to the inclusion criteria. Finally, a total of 313 patients with drug-naïve first-episode psychosis and 238 healthy control subjects from 5 studies were included in our meta-analysis. There were no significant differences between first-episode psychosis patients and healthy controls with respect to the levels of IL-17 (p = 0.21), even when we removed 2 studies which were not European samples (p = 0.12). Our findings suggested that IL-17 may not be involved in the pathological mechanism of schizophrenia.

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“…Patients diagnosed with schizophrenia have increased serum and CSF concentrations of proinflammatory cytokines, including IL-6, IL-1β, IL-17A, and TGF-β 138–141 , and recent findings confirm an association between the IL-23/IL-17 immune axis and schizophrenia 141, 142 . Circulating peripheral T lymphocytes, including Th17 cells, can directly influence CNS immune homeostasis and promote neuroinflammation 141–143 .…”

Section: Fetal Origins Of Childhood and Adult Disease Caused By Matermentioning

confidence: 76%

Chorioamnionitis, IL‐17A, and fetal origins of neurologic disease

Lawrence

Wynn

2017

American J Rep Immunol

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The Centers for Disease Control and Prevention estimate that 1 in 323 infants have cerebral palsy. Highly correlated to intrauterine infection and inflammation, the incidence of cerebral palsy has remained constant over the last few decades despite significant advances in neonatal intensive care including improved ventilator techniques, surfactant therapy, maternal steroid administration, and use of intrapartum empiric antimicrobials. Recent advances in our understanding of immune responses to infection and inflammation have identified the cytokine IL-17A as a crucial component of early pro-inflammatory mediators that cause brain injury associated with neurologic impairment. Remarkably, maternal inflammatory responses to in utero inflammation and infection can also lead to potentially debilitating neurologic conditions in the offspring, which often become clinically apparent during childhood and/or early adulthood. This review details the role of IL-17A in fetal and maternal proinflammatory responses that lead to fetal brain injury and neurologic sequelae, including cerebral palsy. Recent findings regarding the role of maternal inflammatory responses in the development of childhood and adult neurologic conditions, such as autism, schizophrenia, and multiple sclerosis, will also be highlighted.

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Increased Interleukin-17 and decreased BAFF serum levels in drug-free acute schizophrenia

Cited by 38 publications

References 52 publications

Possible Role of TGF – B Pathways in Schizophrenia / Moguća Uloga TTGF - B Signalnih Puteva U Shizofreniji

Possible Role of TGF – B Pathways in Schizophrenia / Moguća Uloga TTGF - B Signalnih Puteva U Shizofreniji

Interleukin-17 Alteration in First-Episode Psychosis: A Meta-Analysis

Chorioamnionitis, IL‐17A, and fetal origins of neurologic disease

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