Possible Role of TGF – B Pathways in Schizophrenia / Moguća Uloga TTGF - B Signalnih Puteva U Shizofreniji

Borovcanin, M.; Jovanović, Ivan; Dejanovic, Slavica Djukic; Radosavljević, Gordana; Arsenijević, Nebojša; Lukic, Miodrag L.

doi:10.1515/sjecr-2015-0038

Cited by 4 publications

(1 citation statement)

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“…TGF-b (Transforming Growth Factor) is a protein that converts cytokines into growth factors. It's a crucial cytokine, especially for the immune system, but it's also been linked to non-immune functions (Borovcanin et al 2016). TGF binds to TGF receptors I and II, which are serine/threonine kinases that phosphorylate intracellularly.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Serum Usp9x and TGF-ß Levels in Children With Asd Spectrum Disorders With Healthy Controls

Karadağ

Turgut²,

Çiftçi

et al. 2022

Preprint

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Introduction: The etiology of autism spectrum disorder (OSB) is a complicated neurodevelopmental disease that is influenced by a number of unknown factors. Ubiquitin-specific proteins (USP) have been found to alter etiology in recent animal studies. However, there is no human study on the subject that we are aware of. The purpose of this research is to determine the differences and correlations between USP9X and TGFb exposure levels in healthy OSB controls, as well as the violence and correlations. Methods The children in the research ranged in age from 3 to 12, with 41 having ASD. The Childhood Autism Rating Scale (CARS), the Gilliam Autism Rating Scale-2, and sociodemographic questionnaires were completed by the participants (GARS TV-2). The parameters USP9X and TGFb were measured in peripheral blood samples using the ELISA technique. Results When the levels of USP9X and TGBb in children with ASD and healthy controls were compared, it was shown that the level of USP9X in children with ASD was statistically substantially higher (11.94 vs 8.77, p: 0.001), but the level of TGFb was not significantly different. The difficulty to make eye contact subscale showed a positive link in the correlation study between the CARS and TV-GARS-2 questionnaires and blood measurements. Discussion USP9X levels have been found to be high in children with ASD, independent of severity, necessitating additional investigation as a potential etiological target.

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Section: Introductionmentioning

confidence: 99%