Increased functional connectivity strength of right inferior temporal gyrus in first-episode, drug-naive somatization disorder

Abstract

Background: Evidence of brain structural and functional alterations have been implicated in patients with somatization disorder (SD). However, little is known about brain functional connectivity in SD. In the present study, resting-state functional magnetic resonance imaging (fMRI) and graph theory were used to obtain a comprehensive view of wholebrain functional connectivity and to investigate the changes of voxel-wise functional networks in patients with SD.Methods: Twenty-five first-episode, medication-naive patients with SD and 28 age-, sex-and education-matched healthy controls (HCs) underwent resting-state fMRI. The graph theory approach was employed to analyze the data.Results: Compared to the HCs, patients with SD showed significantly increased functional connectivity strength in the right inferior temporal gyrus (ITG). There is a significant positive correlation between the z-values of the cluster in the right ITG and Hamilton Anxiety Scale scores. Conclusions:Our findings indicate that there is a disruption of the functional connectivity pattern in the right ITG in first-episode, treatment-naive patients with SD, which bears clinical significance.

Increased short-range and long-range functional connectivity in first-episode, medication-naive schizophrenia at rest

“…Increased FC is typically interpreted as compensatory reallocation or dedifferentiation (Cabeza et al, 2002;Grady et al, 2005;Guo et al, 2013;Su et al, 2015). Previously, we reported increased causal connectivity biased by structural deficits in the same patient sample .…”

Altered functional connectivity strength and its correlations with cognitive function in subjects with ultra‐high risk for psychosis at rest

“…Over the last decade, the importance of graph theoretical analysis combined with resting‐state fMRI has been emphasized . Graph theoretical analysis, originated from the discovery of small‐world and scale‐free networks, is an unbiased method to examine whole‐brain functional connectome.…”

Abnormal Functional Connectivity Density in New-Onset Type 1 Diabetes Mellitus Children: A Resting-State Functional Magnetic Resonance Imaging Study

“…The left OIFG is related to oral and sign language grammar processing, music grammar, and language semantics, and involves in the language process (35). Except as one part of the visual network, the right ITG is also the central portion of the language formulation area region and involves in language (36)(37)(38) The increase in FC between right ITG and left OIFG may be a compensatory or adaptive response to impaired language performance in T1DM patients (39).…”