Increased short-range and long-range functional connectivity in first-episode, medication-naive schizophrenia at rest

Guo, Wenbin; Liu, Feng; Xiao, Changfu; Liu, Jianrong; Yu, Miaoyu; Zhang, Zhikun; Zhang, Jian; Zhao, Jingping

doi:10.1016/j.schres.2015.04.034

Cited by 47 publications

(40 citation statements)

References 68 publications

(95 reference statements)

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“…Further ROC analyses indicated that the lFCS of the right MTG may be a candidate biomarker to distinguish BD from MDD and from controls at the highest classification power (Table 3). Increased functional connectivity is typically interpreted as compensatory reallocation or dedifferentiation 57–59 . Several structural MRI studies of BD patients found decreased cortical thickness in temporal regions, including the superior, middle, and inferior temporal gyri 60–62 .…”

Section: Discussionmentioning

confidence: 99%

Shared and Specific Intrinsic Functional Connectivity Patterns in Unmedicated Bipolar Disorder and Major Depressive Disorder

Wang

Jia

et al. 2017

Sci Rep

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Identifying brain differences and similarities between bipolar disorder (BD) and major depressive disorder (MDD) is necessary for increasing our understanding of the pathophysiology and for developing more effective treatments. However, the features of whole-brain intrinsic functional connectivity underlying BD and MDD have not been directly compared. We collected resting-state fMRI data from 48 BD patients, 48 MDD patients, and 51 healthy subjects. We constructed voxel-wise whole-brain functional networks and computed regional functional connectivity strength (FCS) using graph-theory and further divided the regional FCS into long-range FCS (lFCS) and short-range FCS (sFCS). Relative to the controls, both the BD and MDD patients showed decreased sFCS in the bilateral precuneus. In addition, the BD patients showed increased and the MDD patients showed decreased lFCS and sFCS in the bilateral cerebellum. The BD patients also showed increased lFCS in the right middle temporal gyrus and increased sFCS in the bilateral thalamus compared to either the MDD patients or the controls. These findings suggest that BD and MDD may have some shared as well as a greater number of specific impairments in their functional connectivity patterns, providing new evidence for the pathophysiology of BD and MDD at the large-scale whole brain connectivity level.

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Section: Discussionmentioning

confidence: 99%

Shared and Specific Intrinsic Functional Connectivity Patterns in Unmedicated Bipolar Disorder and Major Depressive Disorder

Wang

Jia

et al. 2017

Sci Rep

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“…Sepulcre et al, 2010), ranging from 12mm (Mueller et al, 2013) to 75mm (e.g. Guo et al 2014, Liang et al 2013, Guo et al 2015), to be differentiated from long-range FC. Short-range FC, quantified as regional homogeneity (ReHo) (Zang et al, 2004), has also been defined as the connectivity of a given voxel to those of its nearest neighboring voxels, ranging from 6 voxels (Shukla et al, 2010) to 26 voxels (e.g.…”

Section: What Is Short-range Structural and Functional Connectivity?mentioning

confidence: 99%

“…Alexander-Bloch et al, 2013; Guo et al 2014; Guo et al 2015; Jiang et al 2015; Repovs et al, 2011; Su et al, 2015; Wang et al, 2014). Increased short-range FC has been found in left superior medial frontal gyrus (Guo et al, 2015), right superior frontal gyrus (Jiang et al, 2015), DMN (Repovs et al, 2011), subcortical system and interhemispheric links (Guo et al, 2014) in patients with SZ. On the other hand, reduced short-range connectivity in the right postcentral gyrus, left middle occipital cortex (Jiang et al, 2015) or in a whole brain manner (Alexander-Bloch et al; 2013; Wang et al, 2014) has been shown.…”

Section: Atypical Development Of Short-range Connectivity In Humanmentioning

confidence: 99%

Short-range connections in the developmental connectome during typical and atypical brain maturation

Ouyang

Kang

Detre

et al. 2017

Neuroscience & Biobehavioral Reviews

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The human brain is remarkably complex with connectivity constituting its basic organizing principle. Although long-range connectivity has been focused on in most research, short-range connectivity is characterized by unique and spatiotemporally heterogeneous dynamics from infancy to adulthood. Alterations in the maturational dynamics of short-range connectivity has been associated with neuropsychiatric disorders, such as autism and schizophrenia. Recent advances in neuroimaging techniques, especially diffusion magnetic resonance imaging (dMRI), resting-state functional MRI (rs-fMRI), electroencephalography (EEG) and magnetoencephalography (MEG), have made quantification of short-range connectivity possible in pediatric populations. This review summarizes findings on the development of short-range functional and structural connections at the macroscale. These findings suggest an inverted U-shaped pattern of maturation from primary to higher-order brain regions, and possible “hyper-” and “hypo-” short-range connections in autism and schizophrenia, respectively. The precisely balanced short- and long-range connections contribute to the integration and segregation of the connectome during development. The mechanistic relationship among short-range connectivity maturation, the developmental connectome and emerging brain functions needs further investigation, including the refinement of methodological approaches.

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“…These changes are considered to be due to modifications of neuronal activity and cerebral vascular function (Abbott, Jaramillo, Wilcox, & Hamilton, ; Rӧder, Dieleman, van der Veen, & Linden, ). In addition, although the data are limited, studies with unmedicated patients with schizophrenia have also reported decreased or increased large‐scale functional networks (Guo et al, ; Kraguljac et al, ; Lui et al, ). A recent study reported that schizophrenia patients in an active psychotic episode (mean PANSS score of 81, as compared to 62 in the present medicated group) had decreased functional connectivity of striatal regions with insula and cortical areas (Peters et al, ).…”

Section: Discussionmentioning

confidence: 99%

Altered connectivity between striatal and extrastriatal regions in patients with schizophrenia on maintenance antipsychotics: an [¹⁸F]fallypride PET and functional MRI study

Kim

Cumming

Son

et al. 2018

Synapse

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In addition to probing regional differences in receptor availability, molecular positron emission tomography (PET) is proving useful for investigating perturbations in neurotransmitter networks using interregional correlation analyses. In a multi-modal imaging study, we examined interregional correlations of dopamine D receptor availability between striatal and extrastriatal regions using [ F]fallypride high-resolution PET in 11 patients with schizophrenia receiving low-dose maintenance atypical antipsychotics and 14 healthy control subjects, and investigated resting-state functional connectivity in the same subjects using seed-based functional magnetic resonance imaging (fMRI) analysis. In the healthy control group, there were no significant correlations of [ F]fallypride binding potential (BP ) between striatal regions and any cortical areas, whereas the patient group showed significant and widespread inter-correlations. Correlations between BP in striatum, amygdala and insula with cortex were significantly higher in patients than in controls. In seed-based resting-state fMRI analysis, the healthy controls revealed positive and negative functional connectivity patterns, while patients exhibited a pattern of exclusively positive connectivity. Functional connectivity was significantly higher between striatal regions and extrastriatal areas including cortical regions in patients compared to controls. In this first such report, molecular and functional connectivity between striatal and extrastriatal regions was primarily characterized by increased interregional relationships in treated patients with schizophrenia. The results suggest that the spatial organization of D receptor availability and related functional connectivity are significantly perturbed in stable outpatients on maintenance antipsychotics. Future studies should include antipsychotic-naïve patients to determine if these relationships are illness-related characteristics, or arising due to chronic antipsychotic treatment.

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Increased short-range and long-range functional connectivity in first-episode, medication-naive schizophrenia at rest

Cited by 47 publications

References 68 publications

Shared and Specific Intrinsic Functional Connectivity Patterns in Unmedicated Bipolar Disorder and Major Depressive Disorder

Shared and Specific Intrinsic Functional Connectivity Patterns in Unmedicated Bipolar Disorder and Major Depressive Disorder

Short-range connections in the developmental connectome during typical and atypical brain maturation

Altered connectivity between striatal and extrastriatal regions in patients with schizophrenia on maintenance antipsychotics: an [¹⁸F]fallypride PET and functional MRI study

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Increased short-range and long-range functional connectivity in first-episode, medication-naive schizophrenia at rest

Cited by 47 publications

References 68 publications

Shared and Specific Intrinsic Functional Connectivity Patterns in Unmedicated Bipolar Disorder and Major Depressive Disorder

Shared and Specific Intrinsic Functional Connectivity Patterns in Unmedicated Bipolar Disorder and Major Depressive Disorder

Short-range connections in the developmental connectome during typical and atypical brain maturation

Altered connectivity between striatal and extrastriatal regions in patients with schizophrenia on maintenance antipsychotics: an [18F]fallypride PET and functional MRI study

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Altered connectivity between striatal and extrastriatal regions in patients with schizophrenia on maintenance antipsychotics: an [¹⁸F]fallypride PET and functional MRI study