Increased frequency of lymphocytotoxic antibodies in patients with multiple sclerosis correlated with disease activity.

Tsukamoto, Tetsuro; Ebina, Takusaburo; Takase, Sadao; Itahara, Katsuya; Ishida, Nakao

doi:10.1620/tjem.136.121

Cited by 4 publications

(2 citation statements)

References 23 publications

(7 reference statements)

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“…All MS sera positive for lymphotoxins were from patients with active or progressive disease. Tsukamoto and co-workers (108) also observed a marked increase in the incidence of these antibodies in MS patients during periods of increased disease activity (83% of patients positive); others (104,106) did not observe such a correlation. It is suggested that these antibodies may be markers for viral infection associated with MS or may play a role in modulating the immune response, or both.…”

Section: Lymphocytotoxic Antibodiesmentioning

confidence: 91%

Abnormalities of serum and plasma components in patients with multiple sclerosis

Ford

1985

Clinical Biochemistry

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Qualitative and quantitative abnormalities in protein and non-protein components of serum and plasma in patients with multiple sclerosis have been the subjects of numerous reports. In this review many of the more recent observations are documented and evaluated. It is concluded that at present the welter of information that has been gathered does not contribute in any major, coherent way to our understanding of the etiology or pathogenesis of the disorder. Several of the abnormalities that have been observed may be future candidates for biochemical markers for multiple sclerosis; at present none is sufficiently reliable, distinctive or easily performed to warrant the status of a useful diagnostic or prognostic test.

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Section: Lymphocytotoxic Antibodiesmentioning

confidence: 91%

Abnormalities of serum and plasma components in patients with multiple sclerosis

Ford

1985

Clinical Biochemistry

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“…Then the modified T-lymphocytes can be recognized as foreign bodies and anti-modified T-lymphocyte sera will be produced as T. Ebina et al auto-antibodies. These auto-antibodies, frequently found in the sera from MS patients in the exacerbation state, were proved to be detectable as lymphocytotoxic antibodies (10/12 patients, 83%) [10]. As the cell membrane of T-lymphocytes shares common antigens with human brain tissue [1,2,12], it is likely that the virus-induced lymphocytotoxic antibodies would further cross-react with brain cell membranes, leading to the immunopathological demyelination in the central nervous system of MS patients.…”

Section: Introductionmentioning

confidence: 98%

Treatment of multiple sclerosis with anti-measles cow colostrum

Ebina

Sato

Umezu

et al. 1984

Med Microbiol Immunol

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Previous virological and immunological studies have suggested that multiple sclerosis (MS) is an auto-immune disease triggered by a virus infection. In order to inhibit the growth of measles virus in the patient's jejunum, we obtained an IgA-rich cow colostrum containing anti-measles lactoglobulin resistant to proteases. This colostrum was orally administered to patients with MS to investigate its effect on the course of the disease. Measles-positive antibody colostrum was orally administered every morning to 15 patients with MS at a daily dosage of 100 ml for 30 days. Similarly, measles-negative antibody (less than 8) control colostrum was orally administered to 5 patients. As a clinical assessment, disability scores developed by the International Federation of Multiple Sclerosis Societies were used. As a result, of 7 high NT titre (512-5120) anti-measles colostrum recipients 5 patients improved and 2 remained unchanged. Among 8 low NT titre (8-32) anti-measles colostrum recipients 5 patients improved and 3 remained unchanged. However, of 5 negative NT titre (less than 8) colostrum recipients 2 patients remained unchanged and 3 worsened. No side-effects were observed in colostrum recipients. These findings suggest the efficacy of orally administered anti-measles colostrum in improving the condition of MS patients (P less than 0.05).

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The Neurology of Myelin Diseases

Traugott

Raine

1984

Myelin

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Increased frequency of lymphocytotoxic antibodies in patients with multiple sclerosis correlated with disease activity.

Cited by 4 publications

References 23 publications

Abnormalities of serum and plasma components in patients with multiple sclerosis

Abnormalities of serum and plasma components in patients with multiple sclerosis

Treatment of multiple sclerosis with anti-measles cow colostrum

The Neurology of Myelin Diseases

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