Abnormalities of serum and plasma components in patients with multiple sclerosis

Abstract

Qualitative and quantitative abnormalities in protein and non-protein components of serum and plasma in patients with multiple sclerosis have been the subjects of numerous reports. In this review many of the more recent observations are documented and evaluated. It is concluded that at present the welter of information that has been gathered does not contribute in any major, coherent way to our understanding of the etiology or pathogenesis of the disorder. Several of the abnormalities that have been observed may be future candidates for biochemical markers for multiple sclerosis; at present none is sufficiently reliable, distinctive or easily performed to warrant the status of a useful diagnostic or prognostic test.

Elevated Phospholipid Transfer Protein in Subjects with Multiple Sclerosis

“…Alterations in metabolic pathways in subjects with MS have been suggested before [ 2 ]. These include abnormalities in the plasma proteins [ 3 , 4 ], reduced levels of lecithin cholesterol acyltransferase in the brain [ 5 ], alterations in plasma [ 6 , 7 ] and cellular lipid profiles [ 8 , 9 ], and differences in the phospholipid content of normal myelin compared with myelin from subjects with MS [ 10 ].…”

Low Plasma Cyclic Nucleotides in Multiple Sclerosis

“…Low CSF c-AMP was found compared to controls, but the statistical analysis presented does not permit the extraction of more information. Although many bio chemical parameters have been studied in blood of MS patients [Ford, 1985], there is not much known about variables that are connected to the central or peripheral neural activity. We have begun a study on several neuro chemical variables in body fluids of MS patients, and here we report our results for the plasma cyclic nucleo tides in a group of patients with definite MS in re lapse.…”