2015
DOI: 10.1590/s0100-736x2015000300002
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Abstract: A Brazilian field isolate (IBV/Brazil/PR05) of avian infectious bronchitis virus (IBV), associated with development of nephritis in chickens, was previously genotyped as IBV variant after S1 gene sequencing. The aim of this study was to evaluate the levels of IL-6 in kidneys and trachea of birds vaccinated and challenged with IBV/Brazil/PR05 strain, correlating these results with scores of microscopic lesions, specific IBV antigen detection and viral load. The up-regulation of IL-6 and the increased levels of … Show more

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Cited by 11 publications
(11 citation statements)
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“…The scores of microscopic lesions in the kidney samples were determined as previously described [ 6 ]. The parameters evaluated included tubular degeneration and necrosis, and presence of inflammatory infiltrate, and the scores ranged from 0 to 3 according to the severity of lesions.…”
Section: Methodsmentioning
confidence: 99%
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“…The scores of microscopic lesions in the kidney samples were determined as previously described [ 6 ]. The parameters evaluated included tubular degeneration and necrosis, and presence of inflammatory infiltrate, and the scores ranged from 0 to 3 according to the severity of lesions.…”
Section: Methodsmentioning
confidence: 99%
“…After replication at primary site in tracheal mucosa, viraemia and IBV secondary replication are also found in other respiratory tissues (nose, lungs and air sacs) and in many non-respiratory epithelial tissues (kidneys, testes, oviduct, and gastrointestinal tract). Nephritis is commonly observed, mainly in broilers, and depending on the pathotype of the IBV strain and on the bird age, it may cause high mortality, and microscopic lesions of degeneration and necrosis of the renal tubular cells and interstitial inflammatory cell infiltrate [ 3 , 4 , 5 , 6 ].…”
Section: Introductionmentioning
confidence: 99%
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“…Entretanto, a produção de algumas citocinas pró-inflamatórias varia dependendo da estirpe viral do VBI e da linhagem de aves infectadas (ASIF et al, 2007;FERNANDO et al, 2015, OKINO et al, 2017. Por conta disso, a superprodução de algumas citocinas, como IL6, IL1β e IFN, podem resultar em graves lesões patológicas locais, além de não ter efeito no sentido de reduzir a carga viral (ASIF et al, 2007, FERNANDO et al, 2015KAMEKA et al, 2014, OKINO et al, 2017.…”
Section: Imunidade Contra O Vbiunclassified
“…In young chickens, the mortality rate is typically 25-30% but it can approach 80% depending on the virulence of the strain [1].Some strains of IBV cause acute nephritis and urolithiasis associated with the high mortality of infected chickens, more ever, the disease is a predisposing factor for secondary bacterial infection resulting in high mortality and morbidity rate [6]. Replication of IBV occurs primary in tracheal mucosa [7], after replication in tracheal mucosa, viraemia and secondary replication are found in other respiratory tissues as nose, lungs and air sacs and in non-respiratory tissues such as kidneys, gastrointestinal tract, oviduct, and testes [8]. Clinically, most birds infected with IBV showed depression, dullness, reduced feed consumption, ruffled feather, increase water consumption, huddle together under heat source, coughing, gasping, sneezing, tracheal rales, occulonasal discharge and mild swollen of sinus [9,10].…”
Section: Introductionmentioning
confidence: 99%