Increased Expression of Inducible Nitric Oxide Synthase in Nasal Mucosae of Guinea Pigs with Induced Allergic Rhinitis

Chiba, Yoshihiko; Matsuo, Kikuo; Sakai, Hiroyasu; Abe, Kazuho; Misawa, Miwa

doi:10.2500/ajr.2006.20.2852

Cited by 8 publications

(5 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They found no significant difference in the levels of eNOS and nNOS. They reported that excess iNOS may have a role in the pathophysiology of AR (21). The low ADMA levels that we found in the AR group support the description of this relationship.…”

Section: Discussionsupporting

confidence: 78%

Asymmetric Dimethylarginine Levels in Allergic Rhinitis and Nasal Polyposis

Tosun¹

2013

Turk J Med Sci

View full text Add to dashboard Cite

Results of a study designed to examine the behavior of gabion-stepped weirs for energy dissipation are presented in this paper. Laboratory tests were conducted with 8 physical models consisting of 3 diff erent porosities (38%, 40%, and 42%) and 2 slopes (1:1 and 1:2). An iron plate was also placed on each horizontal and vertical step to study and classify the eff ect of step porosity on the energy dissipation rate. A decision tree technique was used to derive if-then rules in order to classify the energy dissipation through the weir models. Results from this study suggest that a decision tree model has an accuracy of 85% in predicting the energy dissipation through a gabion-stepped weir using diff erent attributes. Th e results demonstrate that the decision tree technique can be used as a reasonable method for classifi cation of diff erent parameters involved in energy dissipation through a gabion-stepped weir, and it can eff ectively identify the infl uence of various parameters on energy dissipation.

show abstract

Section: Discussionsupporting

confidence: 78%

Asymmetric Dimethylarginine Levels in Allergic Rhinitis and Nasal Polyposis

Tosun¹

2013

Turk J Med Sci

View full text Add to dashboard Cite

show abstract

“…Li et al reported an increase in iNOS expression in experimental animals that come into contact with an allergen, while there was no change in eNOS and nNOS expression (9) . Yüksel et al and Chiba et al also found similar results (10,11) . In a study, allergic rhinitis (12) .…”

Section: Discussionsupporting

confidence: 52%

Does the maxillary sinus have a triggering role in nasal nitric oxide synthesis?

Güçlü

Uludağ²,

Akçalı³

et al. 2012

Rhin

View full text Add to dashboard Cite

Objectives: We investigated whether the maxillary sinus plays a stimulatory role in nasal nitric oxide (NO) synthesis. Research on sinusitis and nasal polyps has found low NO levels in exhaled air and linked this to obstruction of the ostium. However, the major source of NO in exhaled air is thought to be the nasal mucosa. In this study, Streptococcus pneumoniae was applied to the maxillary sinus to investigate changes in NO synthesis of the nasal mucosa. Methods: An experimental study was performed with New Zealand white rabbits. Three groups, pneumococcus, control and sham, were created. The maxillary sinus of the pneumococcal group was exposed to Streptococcus pneumoniae suspension. Before and after the exposure, bilateral biopsy specimens were taken from the inferior turbinate. Specimens were examined by RT-PCR for expressions of endothelial nitric oxide synthase (e-NOS) and inducible nitric oxide synthase (i-NOS). Physiological saline solution was administered to the maxillary sinus in the control group and biopsies were obtained. The sham group underwent only biopsy. Results: A significant increase in i-NOS expression of tissue samples from the pneumococcal group on the same and opposite sides were detected. There was no increase in e-NOS expression in this group. The control and sham groups had no significant change in i-NOS or e-NOS expression. Conclusion: In the acute period after the maxillary sinus is exposed to a pathogen, i-NOS expression increases in the nasal mucosa, but endothelial NOS expression is not affected. Consequently, a combined response in the maxillary sinus and the nasal mucosa for nitric oxide synthesis is shown in the present study.

show abstract

“…They found that the percentage of mast cells, eosinophils, and macrophages that overexpressed NOS is higher than the percentage of neutrophils and T-cells [25]. Several reports have recognized that the expression and activity of NOS are high in NP [18, 19], in allergic rhinitis [17, 26, 27], and in aspirin-sensitive patients with asthma [28]. However, few studies have focused on the difference between NPs of allergic patients and nonallergic ones with regard to iNOS expression.…”

Section: Discussionmentioning

confidence: 99%

Overexpression of Inducible Nitric Oxide Synthase in Allergic and Nonallergic Nasal Polyp

Sadek

Abdelwahab

Eid

et al. 2019

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

Sinonasal polyps are very common benign lesions of the nasal mucosa. Most of nasal polyps (NP) are idiopathic, and the pathophysiology of this disease is still incompletely understood. Nitric oxide (NO) is a reactive molecule generated by nitric oxide synthase (NOS). NO has been identified as an important mediator in airway function and pathogenesis of several respiratory system diseases. Histological and genetical expression of iNOS was detected to evaluate the role of NO in the pathogenesis of allergic (ANP) and nonallergic nasal polyps (NANP). Forty patients with nasal polyps (20 allergic and 20 nonallergic) were identified by history, clinical examination, and investigation. NPs were obtained from the middle turbinate (MT) during concha bullosa surgery. Twenty normal MT nasal tissues were taken as the control from patients undergoing concha bullosa surgery, without any evidence of allergy or inflammation. A nasal polyp specimen from each patient was subjected for immune-histochemical study followed by histological examination to detect the expression of iNOS. RT-PCR was used to evaluate the iNOS gene expression in isolated tissues. The expression of iNOS in both epithelial and stromal layers was greater in NP than in MT tissues. The ANP group showed more iNOS expression than those of the NANP group. The relative mRNA levels of iNOS gene were significantly higher in ANP (2.5-fold) compared to the normal (1.02-fold, P < 0.001) and NANP (1.5-fold, P < 0.01) groups. NP exhibited a significantly high expression of iNOS at both histological and genetical levels. NO might be an essential factor in the life history of NP. Further studies in a larger sample size are required to explain the probable mechanisms of NO in pathogenesis of NP.

show abstract

Increased Expression of Inducible Nitric Oxide Synthase in Nasal Mucosae of Guinea Pigs with Induced Allergic Rhinitis

Cited by 8 publications

References 31 publications

Asymmetric Dimethylarginine Levels in Allergic Rhinitis and Nasal Polyposis

Asymmetric Dimethylarginine Levels in Allergic Rhinitis and Nasal Polyposis

Does the maxillary sinus have a triggering role in nasal nitric oxide synthesis?

Overexpression of Inducible Nitric Oxide Synthase in Allergic and Nonallergic Nasal Polyp

Contact Info

Product

Resources

About