Asymmetric Dimethylarginine Levels in Allergic Rhinitis and Nasal Polyposis

Tosun, Mehmet

doi:10.3906/sag-1204-111

Cited by 4 publications

(4 citation statements)

References 36 publications

(43 reference statements)

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“…Therefore, ADMA is considered to be associated with endothelial dysfunction. Furthermore, ADMA is considered to be a predictive marker of mortality in critically ill patients (11)(12)(13)(14). Hence, this study was carried out to evaluate asymmetric dimethyl arginine (ADMA) and anti cyclic citrulinated peptide (CCP) in patients with psoriasis.…”

Section: …………………………………………………………………………………………………… Introduction:-mentioning

confidence: 99%

Study of Asymmetric Dimethyl Arginine (Adma) and Anti Cyclic Citrulinated Peptide (Anti-Ccp) in Iraqi Patients With Psoriasis Vulgaris.

MBChB¹,

Ph.D²,

MBChB³

et al. 2016

IJAR

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Background:-Psoriasis is a common chronic, inflammatory, proliferative skin disease that generally presents as chronic sharply demarcated, dull red, scaly plaques, particularly on extensor prominences and the scalp. ADMA is a naturally occurring chemical found in blood plasma. It is a metabolic by-product of continual protein modification processes in the cytoplasm of all human cells. ADMA interferes with L-arginine in the production of nitric oxide, a key chemical involved in normal endothelial function and, by extension, cardiovascular health. Anti-cyclic citrullinated peptides (anti-CCP) are highly specific diagnostic and prognostic markers for rheumatoid arthritis (RA). They have been also found in psoriatic arthritis (PsA), with controversies as regards clinical and radiological associations. Objectives:-To estimate level of anti-cyclic citrullinated peptide and asymmetric dimethyl arginine in sera of Iraqi patients with psoriasis vulgaris compared to healthy controls. Patients / Methods:-Fourty (40) psoriasis patients were recruited from the dermatology Outpatient clinic in Al-Imamain Al-Kadhimain city hospital from December of 2014 to summer of 2015.Patients body mass index (BMI) and waist circumference (WC) were recorded. Fasting serum samples were obtained on enrolment. All the patients did not receive any treatment (locally or systemically), for at least 20 days before enrolment. Age, sex and (BMI) matched with fourty(40) healthy controls were also recruited. Serum ADMA & anti CCP levels were estimated using an Enzyme-Linked Immunosorbant Assay (ELISA) technique (ADMA ELISA Assay Kit-Eagle Biosciences)and for ant-CCP(Anti CCP ELISA Genway GWB-521226). The patients group were subdivided into two groups according to the diseases severity, into mild to moderate psoriasis ,group and severe psoriasis group. Results:-Serum levels of anti-CCP and ADMA were statistically significant elevated in the patients group compared to healthy controls (p < 0.01). Also serum levels of ADMA statistically significant

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Section: …………………………………………………………………………………………………… Introduction:-mentioning

confidence: 99%

Study of Asymmetric Dimethyl Arginine (Adma) and Anti Cyclic Citrulinated Peptide (Anti-Ccp) in Iraqi Patients With Psoriasis Vulgaris.

MBChB¹,

Ph.D²,

MBChB³

et al. 2016

IJAR

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“…Therefore, ADMA is considered to be associated with endothelial dysfunction. Furthermore, ADMA is considered to be a predictive marker of mortality in critically ill patients [ 1 - 4 ].…”

Section: Introductionmentioning

confidence: 99%

Asymmetric dimethylarginine levels in patients with cutaneous anthrax: a laboratory analysis

Sünnetçioğlu

Mengeloglu

Baran

et al. 2014

Ann Clin Microbiol Antimicrob

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BackgroundAsymmetric dimethylarginine (ADMA), the main endogenous inhibitor of nitric oxide synthase, is considered to be associated with endothelial dysfunction. High ADMA levels have been shown to be related with disorders causing vascular inflammation such as hypertension, hypercholesterolemia, atherosclerosis, chronic heart failure, stroke and sepsis. Cutaneous anthrax (CA) is a serious infectious disease which may cause vasculitis. The aim of the study was to investigate the serum ADMA levels in patients with CA.MethodsA total of 35 serum samples of the patients with CA and 18 control sera were tested for ADMA levels using ADMA ELISA kit (Immunodiagnostik AG, Bensheim, Germany).ResultsADMA levels were found to be significantly higher in the patients group than the controls (p < 0.001). In addition, ADMA levels were found to be positively associated with sedimentation rates (R = 0.413; p = 0.026), and inversely associated with international normalized ratio (INR) levels (R = -0.46; p = 0.011). A cut-off value of 0.475 of ADMA had a sensitivity of 74.3%, specificity of 77.8%, and accuracy of 75.5% in the diagnosis of CA.ConclusionAlthough the exact mechanism still remains unclear, ADMA levels could be related to immune activation in CA. In addition, these data might suggest the higher ADMA levels in patients could be due to the perivascular inflammation and vasculitis in CA.

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“…It has been presumed that ADMA has an important role in the regulation of the L-arginine/ nitric oxide (NO) pathway (15,16). NO has a role in pulmonary physiological regulation of bronchodilation, airway responsiveness, and airway inflammation (16,17). Klein et al reported that elevated ADMA concentration results in the inhibition of NOS that leads to smooth muscle constriction in the airway (17).…”

Section: Introductionmentioning

confidence: 99%

“…ADMA is an endogenous nitric oxide synthase (NOS) inhibitor that contributes to cardiovascular disease pathogenesis related to endothelial dysfunctions such as atherosclerosis, diabetes mellitus, and chronic renal disease (13,14). It has been presumed that ADMA has an important role in the regulation of the L-arginine/ nitric oxide (NO) pathway (15,16). NO has a role in pulmonary physiological regulation of bronchodilation, airway responsiveness, and airway inflammation (16,17).…”

Section: Introductionmentioning

confidence: 99%

Neopterin, homocysteine, and ADMA levels during and after urticaria attack

Tuncer¹,

Kaldirim²,

Eyi³

et al. 2015

Turk J Med Sci

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Background/aim: Urticaria is a vascular skin reaction characterized with papules and plaques. Neopterin is accepted as an immunologic marker and an indicator of activation of the immune system. Homocysteine and asymmetric dimethylarginine (ADMA) are the markers of increased vascular resistance. Alteration in vascular resistance has a role in the pathogenesis of urticaria. We aimed to investigate whether there is a relationship between urticaria and neopterin, homocysteine, or ADMA. Materials and methods:The study is designed as a prospective descriptive study and patients with a diagnosis of urticaria in the emergency department were included in the study. Demographic data and characteristics of the disease were recorded. Neopterin, homocysteine, and ADMA levels were measured both during and after urticaria attacks. All data were statistically analyzed. Results:The differences between neopterin levels measured during and after urticaria attacks were statistically significant (P < 0.001). The differences between homocysteine and ADMA levels measured during and after urticaria attacks were not statistically significant (P > 0.05). Conclusion:Our results indicate that neopterin levels in patients with urticaria attacks are increased and the level of neopterin is also a useful parameter in acute urticaria. Further studies should clarify whether homocysteine levels contribute to diagnosis of acute urticaria. However, no relation was found between ADMA and urticaria.

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Asymmetric Dimethylarginine Levels in Allergic Rhinitis and Nasal Polyposis

Cited by 4 publications

References 36 publications

Study of Asymmetric Dimethyl Arginine (Adma) and Anti Cyclic Citrulinated Peptide (Anti-Ccp) in Iraqi Patients With Psoriasis Vulgaris.

Study of Asymmetric Dimethyl Arginine (Adma) and Anti Cyclic Citrulinated Peptide (Anti-Ccp) in Iraqi Patients With Psoriasis Vulgaris.

Asymmetric dimethylarginine levels in patients with cutaneous anthrax: a laboratory analysis

Neopterin, homocysteine, and ADMA levels during and after urticaria attack

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