Neopterin, homocysteine, and ADMA levels during and after urticaria attack

Tuncer, Salim Kemal; Kaldirim, Umit; Eyi, Yusuf Emrah; Yıldırım, Ali Osman; Ekinci, Şafak; Kara, Kemal; Eroğlu, Murat; Öztosun, Muzaffer; Özyürek, Selahattin; Durusu, Murat; Güleç, Mustafa; Çaycı, Tuncer; Altinel, Ozcan; Yamanel, Hüseyin Levent

doi:10.3906/sag-1402-14

Cited by 2 publications

(2 citation statements)

References 33 publications

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“…Neopterin. Neopterin is a compound primarily synthesised by macrophages and monocytes and serves as a marker of immune system activation [29]. Some authors suggest that it can also be seen as a marker of oxidative stress.…”

Section: Immunomodulatory Moleculesmentioning

confidence: 99%

Psoriasis: What Is New in Markers of Disease Severity?

Tampa,

Mitran,

Mitran

et al. 2024

Medicina

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Introduction. Psoriasis is a chronic inflammatory skin disease and is the result of the interaction between numerous external and internal factors. Psoriasis presents a wide range of skin manifestations encompassing individual lesions varying from pinpoint to large plaques that can evolve into generalised forms. The lesions mirror the pathophysiological mechanisms involved in psoriasis pathogenesis, such as inflammation, dysregulation of immune response, uncontrolled proliferation of keratinocytes and angiogenesis. In this article, we present the latest advances achieved regarding markers that correlate with psoriasis severity. Material and method. We have performed a narrative review on markers of psoriasis severity, including articles published between March 2018–March 2023. Results. We have identified four categories of markers: inflammation markers, oxidative stress markers, hormonal markers and cancer-related markers. The main focus was on inflammation biomarkers, including immunomodulatory molecules, haematological parameters, inflammatory cells and costimulatory molecules. Conclusions. The analysed data indicate that markers associated with inflammation, oxidative stress and hormones, and cancer-related markers could be useful in assessing the severity of psoriasis. Nevertheless, additional research is required to ascertain the practical importance of these biomarkers in clinical settings.

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Section: Immunomodulatory Moleculesmentioning

confidence: 99%

Psoriasis: What Is New in Markers of Disease Severity?

Tampa,

Mitran,

Mitran

et al. 2024

Medicina

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“…Neopterin is accepted as an immunologic marker and an indicator of activation of the immune system (7) . Neopterin levels in patients with active RA are noted to be accentuated (8) .…”

Section: Introductionmentioning

confidence: 99%

Serum Neopterin Level in Children with Juvenile Idiopathic Arthritis

Dower

Abdelhameed²,

Maksoud³

et al. 2018

Egyptian Journal of Hospital Medicine

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Background: Juvenile idiopathic arthritis (JIA) is generally considered a clinical syndrome involving several disease subsets, with a number of inflammatory flows, leading to an eventual common pathway in which persistent synovial inflammation and associated damage to articular cartilage and underlying bone are present. Neoptrin is a reliable marker in the assessment of the rate of IFN-γ production. Levels of neoptrin increase in direct proportion with the level of interferon. Measurement of neopterin level is useful because of its relative stability also it is a prognostic indicator for cell-mediated immunity. Aims: This study aims to assess serum level of neopterin in patients with Juvenile Idiopathic Arthritis (JIA) in relation to the disease activity, severity and response to conventional and biological therapy. Methodology: The study was conducted on 30 patients (Group A) previously diagnosed as SoJIA, they were divided into two subgroups according to their therapy into Group AI on biological therapy (15 patients) and Group AII on conventional therapy (15 patients). These in addition to 20 healthy controls (Group B). Results: Basic clinical evaluation and laboratory investigations were done. We found that JIA patients had significantly higher levels of serum neopterin than healthy controls. We also found a highly significant difference between neopterin levels in the activity and remission states among all patients (Group AI and Group AII). Conclusion: We concluded that serum neopterin is a useful marker for cellular immune activation and also indicative of the activity of JIA. Our findings are supported by positive correlations between serum neopterin levels and other markers of activity as TLC, PLT counts, ESR, and CRP. We also concluded that serum neopterin is a sensitive and accurate predictor of disease activity where sensitivity of that test was 93.3% and accuracy was 72.5%. Recommendations: Investigating the serum neopterin measurement in other autoimmune collagen diseases. Assessment the influence of biological therapy on neopterin levels in relation to disease progression.

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Neopterin, homocysteine, and ADMA levels during and after urticaria attack

Cited by 2 publications

References 33 publications

Psoriasis: What Is New in Markers of Disease Severity?

Psoriasis: What Is New in Markers of Disease Severity?

Serum Neopterin Level in Children with Juvenile Idiopathic Arthritis

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