Increased endogenous nitric oxide production induced by physical exercise in peripheral arterial occlusive disease patients

Arosio, Enrico; Cuzzolin, Laura; Marchi, Sergio De; Minuz, Pietro; Degan, Maurizio; Crivellente, Federica; Zannoni, M; Benoni, Giuseppina

doi:10.1016/s0024-3205(99)00550-0

Cited by 21 publications

(21 citation statements)

References 25 publications

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“…25,26 An improvement in cardiac stroke volume, combined with a decrease in total peripheral resistance, would facilitate improved blood flow to lower-limb skeletal muscle groups during walking and might explain the improvement in CD observed in the UL-Ex group. However, other systemic adaptations such as improved endothelial vasoreactivity, 21 nitric oxide metabolism, 22 and blood rheologic adaptations 23 cannot be dismissed on the basis of the evidence presented here.…”

Section: Discussionmentioning

confidence: 74%

“…These include localized metabolic [16][17][18] and blood flow adaptations [18][19][20][21] within the ischemic tissues as well as central cardiovascular adaptations. 8,18,21 Changes in nitric oxide metabolism 22 and endothelial vasoreactivity, 21 in con- junction with altered blood rheology, 23 could also enhance microcirculatory blood flow to exercising skeletal muscles.…”

Section: Discussionmentioning

confidence: 99%

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Upper- vs lower-limb aerobic exercise rehabilitation in patients with symptomatic peripheral arterial disease: A randomized controlled trial

Zwierska

Walker

Choksy

et al. 2005

Journal of Vascular Surgery

147

109

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Our results suggest that a combination of physiologic adaptations and improved exercise pain tolerance account for the improvement in walking performance achieved through upper-limb aerobic exercise training in patients with PAD. Furthermore, that both arm- and leg-crank training could be useful exercise training modalities for improving cardiovascular function, walking performance, and exercise pain tolerance in patients with symptomatic PAD.

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Section: Discussionmentioning

confidence: 74%

Section: Discussionmentioning

confidence: 99%

Upper- vs lower-limb aerobic exercise rehabilitation in patients with symptomatic peripheral arterial disease: A randomized controlled trial

Zwierska

Walker

Choksy

et al. 2005

Journal of Vascular Surgery

147

109

View full text Add to dashboard Cite

show abstract

“…PAD patients are known to have poor endothelial function [29] and reduced NO availability [30,31], and it was therefore expected that they would exhibit an impaired flow response to these tests. Indeed, this study demonstrated significantly lower leg blood flow for PAD compared to healthy controls during passive leg movement (90s AUC) and reactive hyperaemia.…”

mentioning

confidence: 99%

Vasoactive enzymes and blood flow responses to passive and active exercise in peripheral arterial disease

et al. 2016

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“…The specific resistance exercises used was unclear in the remaining 4 (20%) cases. The duration of supervised exercise training ranged from 2 weeks [14,16] to 18 months [25].…”

Section: Resultsmentioning

confidence: 99%

“…Another recent systematic review and meta-analysis involving 2,074 participants across 27 studies demonstrated that supervised exercise improves maximum walking distance to a greater extent than unsupervised exercise (effect size at 12 months = 0.56, 95% confidence intervals 0.34 to 0.77) [5]. Other studies have evaluated the benefits of exercise in PAD patients without claudication [6,7], the effects of exercise on haemodynamic, functional and quality of life outcomes [8][9][10], and the effectiveness of exercise versus alternative treatments such as lower-limb revascularisation [11,12], intermittent pneumatic compression [13], and pharmacological therapy [14][15][16]. This body of research has culminated in supervised exercise programmes being recommended as a first-line therapy for symptomatic PAD in clinical guidelines around the world [17][18][19].…”

Section: Introductionmentioning

confidence: 99%

The Completeness Of Intervention Descriptions In Randomised Trials Of Supervised Exercise Training In Peripheral Arterial Disease

Tew

Brabyn

Cook

et al. 2016

Medicine & Science in Sports & Exercise

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Research supports the use of supervised exercise training as a primary therapy for improving the functional status of people with peripheral arterial disease (PAD). Several reviews have focused on reporting the outcomes of exercise interventions, but none have critically examined the quality of intervention reporting. Adequate reporting of the exercise protocols used in randomised controlled trials (RCTs) is central to interpreting study findings and translating effective interventions into practice. The purpose of this review was to evaluate the completeness of intervention descriptions in RCTs of supervised exercise training in people with PAD. A systematic search strategy was used to identify relevant trials published until June 2015. Intervention description completeness in the main trial publication was assessed using the Template for Intervention Description and Replication checklist. Missing intervention details were then sought from additional published material and by emailing authors. Fifty-eight trials were included, reporting on 76 interventions. Within publications, none of the interventions were sufficiently described for all of the items required for replication; this increased to 24 (32%) after contacting authors. Although programme duration, and session frequency and duration were well-reported in publications, complete descriptions of the equipment used, intervention provider, and number of participants per session were missing for three quarters or more of interventions (missing for 75%, 93% and 80% of interventions, respectively). Furthermore, 20%, 24% and 26% of interventions were not sufficiently described for the mode of exercise, intensity of exercise, and tailoring/progression, respectively. Information on intervention adherence/fidelity was also frequently missing: attendance rates were adequately described for 29 (38%) interventions, whereas sufficient detail about the intensity of exercise performed was presented for only 8 (11%) interventions. Important intervention details are commonly missing for supervised exercise programmes in the PAD trial literature. This has implications for the interpretation of outcome data, the investigation of dose-response effects, and the replication of protocols in future studies and clinical practice. Researchers should be mindful of intervention reporting PLOS ONE |

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Increased endogenous nitric oxide production induced by physical exercise in peripheral arterial occlusive disease patients

Cited by 21 publications

References 25 publications

Upper- vs lower-limb aerobic exercise rehabilitation in patients with symptomatic peripheral arterial disease: A randomized controlled trial

Upper- vs lower-limb aerobic exercise rehabilitation in patients with symptomatic peripheral arterial disease: A randomized controlled trial

Vasoactive enzymes and blood flow responses to passive and active exercise in peripheral arterial disease

The Completeness Of Intervention Descriptions In Randomised Trials Of Supervised Exercise Training In Peripheral Arterial Disease

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