Increased DNA damage in patients with complete hydatidiform mole

Harma, Mehmet; Harma, Müge; Koçyiğit, Abdürrahim; Erel, Özcan

doi:10.1016/j.mrgentox.2005.01.014

Cited by 135 publications

(166 citation statements)

References 17 publications

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“…However, standardized measurement method that can measure the levels of oxidative stress is still not found. Recently, oxidant species or free radicals were monitored by determining total oxidant status (TOS) (Erel et al, 2005), and total antioxidant status (TAS) (Erel et al, 2004) as supposed to supply information on serum oxidative stress index (OSI) of an individual (Harma et al, 2003).…”

Section: Decreased Hdl-dependent Paraoxonase and Arylesterase Enzyme mentioning

confidence: 99%

“…The percentage ratio of TOS to TAS was accepted as oxidative stress index (OSI) (Harma et al, 2003). For calculation, the resulting micromolar unit of TAS was changed to millimoles per liter, and the OSI value was calculated according to the following formula: OSI (arbitrary unit)=TOS (micromolar hydrogen peroxide equivalent per liter)/TAS (micromolar trolox equivalent per liter).…”

Section: Oxidative Stress Indexmentioning

confidence: 99%

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Decreased HDL-Dependent Paraoxonase and Arylesterase Enzyme Activity May Indicate a Worse Prognosis in Multiple Myeloma

Elli̇dağ¹,

Aydın²,

Eren³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: Multiple myeloma (MM) is a haematological cancer characterized by clonal proliferation of plasma cells.The aim of this study was to investigate the activity of serum paraoxonase-1 (PON1) and arylesterase (ARE) in multiple myeloma with and without free light chain excretion(FLCe-MM and NFLCe-MM); as well as to investigate possible alterations in oxidative stress parameters. Materials and Methods: Total thiol (T.thl), oxidative stress index (OSI), total oxidant status (TOS) and total antioxidant status (TAS) were examined in addition to the PON1 and ARE enzyme activities in twenty one FLCe-MM and nineteen NFLCe-MM subjects. Routine parameters like lipid panel, serum total protein, albumin, creatinine, blood urea nitrogen (BUN), uric acid and hemoglobin levels were compared with the oxidative stress markers. Results: Serum total protein, BUN, creatinin, and uric acid levels were significantly higher (p=0.04, p=0.001, p=0.001 and p=0.0022, respectively), while hemoglobin and albumin levels were significantly lower in FLCe-MM patients (p=0.009 and p=0.04,respectively). PON1 and ARE activities were significantly lower in patients with FLCe-MM compared to those with NFLCe-MM (p=0.001 and p=0.008, respectively). Conclusions: Depending on our results of prognostic markers of MM such as age, hemoglobin, albumin, and creatinine we feel confident to presume FLCe-MM as a subgroup with a worse prognosis. A decrease in PON1 and ARE activities may contribute to the prognosis and may be used as a prognostic tool in MM.

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Section: Decreased Hdl-dependent Paraoxonase and Arylesterase Enzyme mentioning

confidence: 99%

Section: Oxidative Stress Indexmentioning

confidence: 99%

Decreased HDL-Dependent Paraoxonase and Arylesterase Enzyme Activity May Indicate a Worse Prognosis in Multiple Myeloma

Elli̇dağ¹,

Aydın²,

Eren³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…Oxidative stress index: The percentage ratio of TOS level to TAS level was suggested as oxidative stress index (OSI) (Harma et al, 2003). For calculation, the resulting micromolar unit of TAS was changed to millimoles per liter, and the OSI value was calculated according to the following formula: OSI (arbitrary unit)=TOS (micromolar hydrogen peroxide equivalent per liter)/TAS (micromolar trolox equivalent per liter).…”

Section: 2759 Ischemia Modified Albumin Levels and Oxidative Stress mentioning

confidence: 99%

“…Furthermore, total antioxidant status (TAS) is a useful indicator of the activity of antioxidants in serum (Erel, 2004). Therefore, measurements of TAS and TOS may show data about body's overall serum oxidative stress index (OSI), which may include antioxidants and oxidants that are not yet known or easily measured (Harma et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Ischemia Modified Albumin Levels and Oxidative Stress in Patients with Bladder Cancer

Elli̇dağ¹,

Eren²,

Aydın³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Background: Impaired oxidative/antioxidative status plays an important role in the pathogenesis of many diseases like cancer. The aim of this study was to evaluate the levels of the novel marker ischemia modified albumin (IMA) and albumin adjusted-IMA (Adj-IMA) in patients with bladder cancer (BC) as well as its association with total antioxidant status (TAS), total oxidant status (TOS) and oxidative stress index (OSI). Materials and Methods: Forty male patients with BC (mean age, 67.4±12 years) and forty age-sex matched healthy persons (mean age 56.0±1.7 years) were included in this study. Serum levels of IMA, TAS, TOS were analyzed and Adj-IMA and OSI was calculated. Results: Serum IMA, TOS and OSI values were significantly higher in patients with BC compared to controls (p<0.0001, p=0.01 and p=0.01, respectively), whereas TAS was significantly lower in BC patients (p=0.04). There was no significant difference for serum albumin-adjusted IMA levels between groups (p=0.4). Conclusions: In this study, it was found that there was an impaired oxidative/antioxidant status in favor of oxidative stress in BC patients. This observation was not confirmed by Adj-IMA calculation. There is no published report about serum concentrations of IMA in patients with BC. Further studies are needed to establish the relationship of IMA and oxidative stress parameters in BC and the significance of IMA to other cancers.

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“…Tissue TAS, TOS, and OSI levels were assayed as described previously 15 by using commercial assay kits (Rel Assay Diagnostics, Gaziantep, Turkey, product numbers: RL0017 and RL0024). Tissue TAS levels were given as µmol Trolox equiv./g of wet tissue and TOS levels were given as µmol H 2 O 2 equiv./g of wet tissue.…”

Section: Biochemical Analysismentioning

confidence: 99%

The Effect of Grape Seed Proanthocyanidin Extract in Preventing Amikacin-Induced Nephropathy

et al. 2012

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Background/Aims: Nephrotoxicity induced by aminoglycosides (AGs) limits their clinical use. As yet, no molecules have been approved to prevent AG nephropathy. We aim to investigate the effectiveness of grape seed proanthocyanidin extract (GSPE) in the prevention of amikacin (AK)-induced nephrotoxicity. Methods: A total of 24 rats were allocated into control, GSPE, AK, and AK + GSPE groups. While 1 mL saline was administered for 6 days in control and AK groups, 100 mg/kg GSPE was administered in GSPE and AK + GSPE groups. On day 7, intraperitoneal (i.p.) saline was administered in control and GSPE groups, while 1.2 g/kg i.p. AK was administered in AK and AK + GSPE groups. The experiment was terminated on day 9. Blood samples were taken for the measurement of renal functions. Renal tissues of the rats were removed for the analysis of malondialdehyde (MDA), total oxidant system (TOS), total antioxidant system, oxidative stress index (OSI), and for histopathological examination. Results: MDA level was found to be lower in GSPE group compared with other study groups. There was significantly more renal histopathological damage and higher blood urea nitrogen, creatinine, TOS, OSI, and MDA levels in the AK group compared with the control and AK + GSPE groups. The same parameters showed significant improvement in AK + GSPE group compared with AK group. Conclusion: Our findings demonstrate for the first time that GSPE reduces oxidative damage in AK nephropathy and provides biochemical and renal histopathological improvements.

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Increased DNA damage in patients with complete hydatidiform mole

Cited by 135 publications

References 17 publications

Decreased HDL-Dependent Paraoxonase and Arylesterase Enzyme Activity May Indicate a Worse Prognosis in Multiple Myeloma

Decreased HDL-Dependent Paraoxonase and Arylesterase Enzyme Activity May Indicate a Worse Prognosis in Multiple Myeloma

Ischemia Modified Albumin Levels and Oxidative Stress in Patients with Bladder Cancer

The Effect of Grape Seed Proanthocyanidin Extract in Preventing Amikacin-Induced Nephropathy

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